Regional emphysema score is associated with tumor location and poor prognosis in completely resected NSCLC patients

Heo, Jung Sun; Kang, Hye Seon; Park, Chan Kwon; Kim, Sung Kyoung; Kim, Ju Sang; Kim, Jin Woo; Kim, Seung Joon; Lee, Sang Haak; Yeo, Chang Dong

doi:10.1186/s12890-020-01268-7

Cited by 8 publications

(12 citation statements)

References 49 publications

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“…Tumor grade was served as a prognostic factor in non-small cell lung cancer patients, according to previous studies ( 16 , 17 ). However, previous studies were mainly aimed at the squamous cell carcinoma or adenocarcinoma population, and there is a lack of research on the effect of tumor differentiation on the prognosis of ASC patients.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Examined Lymph Nodes and Lymph Node Ratio on Pathological Nodal Classification in the Lung Adenosquamous Carcinoma After Lobectomy

et al. 2022

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ObjectiveThe effects of examined lymph nodes (LNs) and lymph node ratio (LNR) on pN classification and the prognosis are unclear in lung adenosquamous carcinoma (ASC) patients. Thus, this study aimed to investigate the significance of LNs and LNR in the prognosis of ASC and the impact of the abovementioned factors on the pN classification.MethodsPatients diagnosed with pathological stage T1-4N0-2M0 ASC from the Surveillance Epidemiology and End Results database were included in the study. The primary clinical endpoint was cancer-specific survival (CSS). The optimal cutoff values of the LNs and LNR were determined. An LN indicator, including pN0 #LNs ≤9, pN0 #LNs >9, pN+ #LNR ≤0.53, and pN+ #LNR > 0.53, was developed. Concordance index (C-index) was used to compare the prognostic predictive ability between N classification and LN indicator. The univariable and multivariable Cox regression analyses were used in this study.ResultsThe cohort of 1,416 patients were included in the study. The level of LNs stratified the patients without metastasis of lymph nodes (pN0 #LNs ≤9 vs. pN0 #LNs >9, unadjusted hazard ratio [HR] = 1.255, P = 0.037). Two groups based on the cutoff value of LNR differentiated prognosis of patients with metastasis of lymph nodes (pN+ #LNR >0.53 vs. pN+ #LNR ≤0.53, unadjusted HR = 1.703, P = 0.001). The LN indicator had a much better predictive ability over N classification in this cohort (LN indicator: C-index = 0.615; N classification: C-index = 0.602, P = 0.001).ConclusionsWe explored clinicopathological factors affecting prognosis in resected lung ASC patients. Besides, the LN indicator was confirmed to be played an essential role in affecting the survival rate in ASC patients. The high-level LNs or low-level LNR might be corelated to improved survival outcomes.

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Section: Discussionmentioning

confidence: 99%

The Effect of Examined Lymph Nodes and Lymph Node Ratio on Pathological Nodal Classification in the Lung Adenosquamous Carcinoma After Lobectomy

et al. 2022

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“…The inclusion criteria were pathologically confirmed primary NSCLC, no relapse up to 12 months after surgery, and R0 resection. Relapse was defined based on radiological or histological evidence of cancer within 12 months after treatment [ 18 , 19 ]. The study included 238 patients who underwent pulmonary function test (PFT) during the evaluation period (6 ± 3 months).…”

Section: Methodsmentioning

confidence: 99%

“…FEV 1 , FEV 1 /forced vital capacity (FVC), the diffusing capacity of the lung for carbon monoxide (DL CO ), and the residual volume (RV)/total lung capacity (TLC) were measured three times: before surgery, 6 ± 3 months (abbreviated as 6 months for convenience) after surgery, and 12 ± 3 months (abbreviated as 12 months) after surgery. Based on smoking history, the patients were grouped into never smokers if they never smoked or if they had smoked less than 100 cigarettes in their lifetime, and ever smokers if they had smoked at least 100 cigarettes in their lifetime [ 18 , 21 ]. PFT was performed in accordance with the American Thoracic Society/European Respiratory Society standardization guidelines.…”

Section: Methodsmentioning

confidence: 99%

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The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer

Kwon

Yeo

Lee

et al. 2021

JCM

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Chronic obstructive pulmonary disease (COPD) is one of the most frequently occurring concomitant diseases in patients with non-small cell lung cancer (NSCLC). It is characterized by small airways and the hyperinflation of the lung. Patients with hyperinflated lung tend to have more reserved lung function than conventionally predicted after lung cancer surgery. The aim of this study was to identify other indicators in predicting postoperative lung function after lung resection for lung cancer. Patients with NSCLC who underwent curative lobectomy with mediastinal lymph node dissection from 2017 to 2019 were included. Predicted postoperative FEV1 (ppoFEV1) was calculated using the formula: preoperative FEV1 × (19 segments-the number of segments to be removed) ÷ 19. The difference between the measured postoperative FEV1 and ppoFEV1 was defined as an outcome. Patients were categorized into two groups: preserved FEV1 if the difference was positive and non-preserved FEV1, if otherwise. In total, 238 patients were included: 74 (31.1%) in the FEV1 non-preserved group and 164 (68.9%) in the FEV1 preserved group. The proportion of preoperative residual volume (RV)/total lung capacity (TLC) ≥ 40% in the FEV1 non-preserved group (21.4%) was lower than in the preserved group (36.1%) (p = 0.03). In logistic regression analysis, preoperative RV/TLC ≥ 40% was related to postoperative FEV1 preservation. (adjusted OR, 2.02, p = 0.041). Linear regression analysis suggested that preoperative RV/TLC was positively correlated with a significant difference. (p = 0.004) Preoperative RV/TLC ≥ 40% was an independent predictor of preserved lung function in patients undergoing curative lobectomy with mediastinal lymph node dissection. Preoperative RV/TLC is positively correlated with postoperative lung function.

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“…To analyze the differences between the 48 lung cancer patients who had active pulmonary TB and the patients without TB, we used the data from 575 lung cancer patients collected at the same hospital during the same period. This study used the Catholic Medical Center (CMC) lung cancer registry containing data from seven hospitals ( (14)(15)(16). We analyzed data of the lung cancer patients without TB diagnosed at Seoul, Eunpyeong, Bucheon, and Uijeongbu from January 2009 to December 2017.…”

Section: Registry Datamentioning

confidence: 99%

Clinical characteristics and survival of patients concurrently diagnosed with lung cancer and active pulmonary tuberculosis

Lee

Heo

Kang³

et al. 2021

Preprint

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Background Active pulmonary tuberculosis (TB) occasionally coexists with lung cancer. However, the clinical and radiologic characteristics of this cooccurrence have not been fully evaluated. Methods Patients diagnosed with lung cancer and active pulmonary TB from January 2009 to December 2017 in four hospitals of the Catholic University of Korea were retrospectively reviewed. The clinical characteristics, including the TB diagnosis methods, lung cancer pathology, staging, initial radiographic features, and survival were analyzed and compared to 575 lung cancer patients without active pulmonary TB from the same hospitals. Results Forty-eight (0.48%) of the 9,936 lung cancer patients had active pulmonary TB confirmed by positive culture results or polymerase chain reaction analysis for M. tuberculosis at the time of the initial cancer diagnosis. The majority of the patients (95.9%) had non-small cell lung cancer and 56.2% of the lung cancers were located in the both upper lobes. In the initial computed tomography, the most frequent findings were a mass-like lesion (79.2%) and separate nodules (75%). When compared to lung cancer patients without TB, the body mass index (BMI) was lower (21.4 vs. 23.1, P = 0.001) in patients with TB. Moreover, the lung cancer patients with TB had advanced clinical stages compared to patients without TB; T3-4 (70.9% vs. 50.6%, P = 0.002), N2-3 (85.2% vs. 55.6%, P < 0.001); M1 (65.9% vs. 44.5%, P = 0.007). Patients' age, histology, location, and the presence of epidermal growth factor receptor mutations were not statistically different between the two groups. Interestingly, lung cancer with TB was associated with lower mortality (hazard ratio = 0.35, 95% CI: 0.2 1– 0.60). Conclusions Rarely diagnosed concurrent active tuberculosis in lung cancer patients was associated with lower BMI and advanced clinical stages. Active investigation of and treatment for active pulmonary TB in lung cancer patients could improve patient outcomes.

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Regional emphysema score is associated with tumor location and poor prognosis in completely resected NSCLC patients

Cited by 8 publications

References 49 publications

The Effect of Examined Lymph Nodes and Lymph Node Ratio on Pathological Nodal Classification in the Lung Adenosquamous Carcinoma After Lobectomy

The Effect of Examined Lymph Nodes and Lymph Node Ratio on Pathological Nodal Classification in the Lung Adenosquamous Carcinoma After Lobectomy

The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer

Clinical characteristics and survival of patients concurrently diagnosed with lung cancer and active pulmonary tuberculosis

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