Regional differences in the arterial response to vasopressin: role of endothelial nitric oxide

Garcı́a-Villalón, Ángel Luis; García, José Luis Rueda; Fernández, Núria; Monge, Luis; Gómez, B.; Diéguez, Godofredo

doi:10.1111/j.1476-5381.1996.tb15613.x

Cited by 95 publications

(58 citation statements)

References 22 publications

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“…Taking into account the lower systemic clearance of FE 202158 in the rat (9.4 ml/kg/min) compared with AVP (ϳ50 ml/kg/min) (Crofton et al, 1986), the above ED 50 values would correspond to EC 50 values of ϳ0.43 nM for FE 202158 and ϳ0.068 nM for AVP. The ear pinna vascular bed is exquisitely sensitive to the vasoconstrictor effect of AVP, being up to 10 times more sensitive than other vascular beds (Garcia-Villalón, 1996), which would explain why both FE 202158 and AVP are ϳ10 times more potent here than in the isolated common iliac artery.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V_1aReceptor Full Agonist for the Treatment of Vasodilatory Hypotension

Laporte¹,

Kohan²,

Heitzmann³

et al. 2011

J Pharmacol Exp Ther

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R), and oxytocin receptor, respectively] contrasting with AVP's lack of selectivity, especially versus the V 2 R (selectivity ratio of 1:18:0.2:92; human V 1a R EC 50 ϭ 0.24 nM). This activity and selectivity profile was confirmed in radioligand binding assays. FE 202158 was a potent vasoconstrictor in the isolated rat common iliac artery ex vivo (EC 50 ϭ 3.6 nM versus 0.8 nM for AVP) and reduced rat ear skin blood flow after intravenous infusion in vivo (ED 50 ϭ 4.0 versus 3.4 pmol/kg/min for AVP). The duration of its vasopressor effect by intravenous bolus in rats was as short as AVP at submaximally effective doses. FE 202158 had no V 2 R-mediated antidiuretic activity in rats by intravenous infusion at its ED 50 for reduction of ear skin blood flow, in contrast with the pronounced antidiuretic effect of AVP. Thus, FE 202158 seems suitable for treatment of conditions where V 1a R activity is desirable but V 2 R activity is potentially deleterious, such as vasodilatory hypotension in septic shock. In addition to the desirable selectivity profile, its shortacting nature should allow dose titration with rapid onset and offset of action to optimize vasoconstriction efficacy and safety.

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Section: Discussionmentioning

confidence: 99%

Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V_1aReceptor Full Agonist for the Treatment of Vasodilatory Hypotension

Laporte¹,

Kohan²,

Heitzmann³

et al. 2011

J Pharmacol Exp Ther

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“…The vasoconstrictive response to KCl (120 mmol/l) is usually used to assess the contractile ability of the vascular smooth muscle. Agonist-induced vasoconstrictions are often standardized by E max·KCl in order to eliminate an influence of the different thickness of muscle layer in larger and smaller arteries [30][31][32]. Therefore, it was reasonable to compare the magnitude of the vasoconstriction induced by α,β-MeATP with that induced by NA, regardless of the responses expressed as g/mg tissue or as a percentage of the maximal vasoconstriction to KCl in this study.…”

Section: Discussionmentioning

confidence: 99%

Physiological significance of P2X receptor-mediated vasoconstriction in five different types of arteries in rats

Jia²,

Chen

et al. 2011

Purinergic Signalling

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P2X 1 receptors, the major subtype of P2X receptors in the vascular smooth muscle, are essential for α,β-methylene adenosine 5′-triphosphate (α,β-MeATP)-induced vasoconstriction. However, relative physiological significance of P2X 1 receptor-regulated vasoconstriction in the different types of arteries in the rat is not clear as compared with α 1 -adrenoceptor-regulated vasoconstriction. In the present study, we found that vasoconstrictive responses to noncumulative administration of α,β-MeATP in the rat isolated mesenteric arteries were significantly smaller than those to single concentration administration of α,β-MeATP. Therefore, we firstly reported the characteristic of α,β-MeATP-regulated vasoconstrictions in rat tail, internal carotid, pulmonary, mesenteric arteries, and aorta using single concentration administration of α,β-MeATP. The rank order of maximal vasoconstrictions for α,β-MeATP (E max·α,β-MeATP ) was the same as that of maximal vasoconstrictions for noradrenaline (E max·NA ) in the internal carotid, pulmonary, mesenteric arteries, and aorta. Moreover, the value of (E max·α,β-MeATP /E max·KCl )/(E max·NA /E max·KCl ) was 0.4 in each of the four arteries, but it was 0.8 in the tail artery. In conclusion, P2X 1 receptor-mediated vasoconstrictions are equally important in rat internal carotid, pulmonary, mesenteric arteries, and aorta, but much greater in the tail artery, suggesting its special role in physiological function.

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“…This result supports the theory that less fluid administration leads to less fluid shift of vascular fluid into interstitial tissue, improved oxygen delivery, and a faster recovery rate. This is an important advantage because vasopressin can preserve blood flow in important vital organs without adequate body fluids [6,21], delay multiorgan failure, and help escape the vicious cycle of decompensatory shock [16]. On the other hand, catecholamine requires fluid replacement before administration because of the serious complications of vasoconstriction via α 1 -receptor and less sensitivity of α 1 -receptor in hypoxemic environment [19].…”

Section: Discussionmentioning

confidence: 99%

Vasopressor Therapy Using Vasopressin Prior to Crystalloid Resuscitation in Irreversible Hemorrhagic Shock under Isoflurane Anesthesia in Dogs

Yoo

Kim

Eom

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. In the present study, we tested the hypothesis that vasopressin administration prior to crystalloid resuscitation can be used to improve hemodynamic and oxygen delivery functions. Hemorrhagic shock was experimentally induced by maintaining mean arterial pressure at 60 mmHg for 30 min in sixteen healthy dogs weighing from 8 to 10.6 kg. Vasopressin was administered and then volume resuscitation was performed for the 6 dogs of V-C group, while vasopressin was administered at the end of volume resuscitation in the 5 dogs of C-V group. The control group (n=5) was administered 0.4 IU/kg of vasopressin after induction of shock without fluid resuscitation. In all groups, hemodynamic parameters were measured pre-and post-hemorrhage and for 60 min after fluid resuscitation. The dogs in V-C group had substantially increased systolic arterial pressure (SAP) for 60 min and improved pulmonary capillary wedge pressure (PCWP), cardiac output (CO), oxygen delivery, and oxygen consumption indexes compared with C-V and control groups. Diastolic pressure and systemic vascular resistance was significantly lower in the V-C group than those in the C-V and control groups (P<0.05). In the V-C group, there was effective and rapid restoration of the SAP, CO, PCWP, and oxygen delivery parameters after treatment. This study indicates that vasopressin administration before crystalloid resuscitation is a more efficient way of improving hemodynamic and oxygen delivery functions in hemorrhagic shock in dogs.

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Regional differences in the arterial response to vasopressin: role of endothelial nitric oxide

Cited by 95 publications

References 22 publications

Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V_1aReceptor Full Agonist for the Treatment of Vasodilatory Hypotension

Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V_1aReceptor Full Agonist for the Treatment of Vasodilatory Hypotension

Physiological significance of P2X receptor-mediated vasoconstriction in five different types of arteries in rats

Vasopressor Therapy Using Vasopressin Prior to Crystalloid Resuscitation in Irreversible Hemorrhagic Shock under Isoflurane Anesthesia in Dogs

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Regional differences in the arterial response to vasopressin: role of endothelial nitric oxide

Cited by 95 publications

References 22 publications

Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V1aReceptor Full Agonist for the Treatment of Vasodilatory Hypotension

Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V1aReceptor Full Agonist for the Treatment of Vasodilatory Hypotension

Physiological significance of P2X receptor-mediated vasoconstriction in five different types of arteries in rats

Vasopressor Therapy Using Vasopressin Prior to Crystalloid Resuscitation in Irreversible Hemorrhagic Shock under Isoflurane Anesthesia in Dogs

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Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V_1aReceptor Full Agonist for the Treatment of Vasodilatory Hypotension

Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V_1aReceptor Full Agonist for the Treatment of Vasodilatory Hypotension