Regional differences and temporal trends in male reproductive health disorders: Semen quality may be a sensitive marker of environmental exposures

Nordkap, Loa; Joensen, Ulla Nordström; Jensen, Martin Blomberg; Jørgensen, Niels

doi:10.1016/j.mce.2011.05.048

Cited by 148 publications

(107 citation statements)

References 122 publications

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“…This needs to be confirmed with more precise data on men's actual location. In the light of the present results, perennial surveillance of semen quality, which allows assessing temporal and spatial trends in what is considered a public health biomarker (Jensen et al 2009, Joffe 2010 and may even be a sensible biomarker of environmental exposure (Nordkap et al 2012), appears to be necessary. In this context, development and comparison of consistent indicators among countries at a continental level may allow for further progresses in the understanding of patterns in sperm quality and their underlying causes.…”

Section: Resultsmentioning

confidence: 95%

Semen quality trends in French regions are consistent with a global change in environmental exposure

Moal¹,

Rolland²,

Goria³

et al. 2014

Reproduction

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A retrospective study carried out recently in a large sample of men, close to the general population, has reported a significant and strong decline in sperm concentration and morphology in the whole of France between 1989 and 2005. We studied these trends within each region of France. Data were obtained from the Fivnat database. The study sample comprised male partners of sterile women in whom both tubes were absent or blocked. They were located at the assisted reproductive technology center. A Bayesian spatio-temporal model with parametric time trends, adjusted for age, was used to model overall time trends for each region. The results show that sperm concentration decreased in almost all regions of France. Among them, Aquitaine showed the highest decrease and Midi-Pyrénées had the lowest average for the whole period. Regarding total motility, most regions showed a slight increase while Bourgogne showed a steep and significant decrease. While considering sperm morphology, there was a decrease in most of the regions. The decrease in Aquitaine and Midi-Pyrénées was stronger when compared with the overall trend. In conclusion, a decrease in sperm concentration and morphology, already shown at the French metropolitan territory level, was observed in most regions of France. This is consistent with a global change in environmental exposure, according to the endocrine disruptor hypothesis especially. Indeed, ubiquitary exposure to chemicals has been growing in the general population of France since the 1950s, and the results do not appear to support the lifestyle hypothesis. The highest decreases and lowest values are consistently observed in two proximate regions that are both highly agricultural and densely populated.

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Section: Resultsmentioning

confidence: 95%

Semen quality trends in French regions are consistent with a global change in environmental exposure

Moal¹,

Rolland²,

Goria³

et al. 2014

Reproduction

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“…The decline in semen quality, including in countries that previously boasted good sperm characteristics, highlights the male reproductive system as one of the major targets of environmental toxicants [36]. It seems likely that the cumulative effects of various low-dose exposures to environmental contaminants are responsible for male reproductive effects.…”

Section: Discussionmentioning

confidence: 99%

Aluminum exposure for 60 days at human dietary levels impairs spermatogenesis and sperm quality in rats

Martinez

Escobar

Uranga

et al. 2017

Reproductive Toxicology

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Highlights Our study shows that 60-day exposure to low doses of aluminum, which aimed to mimic human exposure to dietary aluminum is able to impair male reproductive health. Strikingly, the reproductive impairment was, sometimes, less-marked at the higher dose of Al, raising concerns regard to safe values for human exposure to aluminum. AbstractConcerns about environmental aluminum (Al) and reproductive health have been raised. We investigated the effects of Al exposure at a human relevant dietary level and a high level exposure to Al. Experiment 1 (Lower level) rats were treated orally for 60 days: a) controls -ultrapure water; b) aluminum at 1.5 mg/kg bw/day and c) aluminum at 8.3 mg/kg bw/day. Experiment 2 (High level) rats were treated for 42 days: a) controls -ultrapure water; b) aluminum at 100 mg/kg bw/day. Al decreased sperm count, daily sperm production, sperm motility, normal morphological sperm, impaired testis histology; increased oxidative stress in reproductive organs and inflammation in testis. Our study shows the specific presence of Al in the germinative cells and, that low concentrations of Al in testes (3.35 μg/g) are sufficient to impair spermatogenesis and sperm quality. Our findings provide a better understanding of the reproductive health risk of Al.

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“…Although this appears to suggest a negligible human male reproductive system risk, phthalates are only one component of a mixture of chemicals to which humans are exposed. Since humans are continuously exposed to multiple combinations of compounds with anti-androgenic and estrogenic effects, it is important to assess the joint action exhibited by mixtures of chemicals that disrupt a common system or target tissue instead of chemicals sharing a narrowly defined mechanism of toxicity Kortenkamp and Faust, 2010;Nordkap et al, 2012). When combined with other EDC in rats, it is clear that phthalates contribute to reproductive toxicity below the no-observed-adverse-effect level of individual phthalate congener exposures (Committee on the Health Risks of Phthalates, 2008;Johnson et al, 2012).…”

Section: Phthalatesmentioning

confidence: 99%

Estrogenic and anti-androgenic endocrine disrupting chemicals and their impact on the male reproductive system

Falco

Forte

Laforgia

2015

Front. Environ. Sci.

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Endocrine disrupting chemicals (EDCs) are identified for their ability to perturb the homeostasis of endocrine system and hormonal balance. The male reproductive system is under close control of hormones and each change in their concentration and time of exposition and action can induce a deregulation of its physiology. In this review we summarize the most recent studies on two main categories of EDCs with different action: the estrogenic bisphenol A and alkylphenols and the anti-androgenic phthalates. This review describes the main effects of these substances on male reproductive system

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Regional differences and temporal trends in male reproductive health disorders: Semen quality may be a sensitive marker of environmental exposures

Cited by 148 publications

References 122 publications

Semen quality trends in French regions are consistent with a global change in environmental exposure

Semen quality trends in French regions are consistent with a global change in environmental exposure

Aluminum exposure for 60 days at human dietary levels impairs spermatogenesis and sperm quality in rats

Estrogenic and anti-androgenic endocrine disrupting chemicals and their impact on the male reproductive system

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