Regional delivery of immunosuppression for transplantation of vascularized composite allografts: opportunities near and far

TNFRSF13B in B cell responses to organ transplantation

“…We think TNFRSF13B functions, including the slowing T cell-dependent B cell responses, providing of a broad range of antibody avidities, providing natural antibodies that divert complement from cell surfaces and facilitate repair among other functions listed above shift help antibody-induced accommodation to eclipse antibody-mediated injury and rejection. By averting antibody-mediated tissue damage, we think it is possible that accommodation could over time also help constrain B cell responses [ 77 – 79 ]. If that is correct, then iterative interactions between the graft and recipient promoted by TNFRSF13B functions might eventually be found to suppress specific B cell responses to the graft, limiting the duration of intensive immunosuppression recipients of xenografts or allografts must receive.…”