Regional decrease in gray matter volume is related to body dissatisfaction in anorexia nervosa

Kohmura, Kunihiro; Adachi, Yasunori; Tanaka, Satoshi; Katayama, Hiroto; Imaeda, Miho; Kawano, Naoki; Nishioka, Kazuo; Ando, Masahiko; Iidaka, Tetsuya; Ozaki, Norio

doi:10.1016/j.pscychresns.2017.07.004

Cited by 18 publications

(31 citation statements)

References 32 publications

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“…The disturbance of body image perception would contribute to body dissatisfaction, which is one of the common symptoms of eating disorders. Kohmura et.al has found decreased GMV in superior temporal gyrus in anorexia nervosa, which is related to body dissatisfaction [23]. We have not found previous studies on the relationship between body dissatisfaction and structural MRI alterations in BN at present.…”

Section: Regional Gmv Changescontrasting

confidence: 67%

Altered regional gray matter volume in Chinese female patients with bulimia nervosa

Liu

Wang

et al. 2019

Preprint

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The bulimia nervosa (BN) is one of the psychiatric disorders, which pathophysiology is not clear currently. Recent studies have concentrated on brain structural and functional changes in BN patients. However, findings have been inconsistent.The aim of this study was to explore the relationships between brain structural alterations and clinical features in Chinese female patients with BN.Method A total of 34 female patients with BN and 34 matched healthy controls (HC) underwent a T1-weighted magnetic resonance imaging (MRI) scanning. VBM analysis was carried out by using SPM8 ( http://www.fil.ion.ucl.ac.uk/spm/software/spm8/ ) to explore the alterations of regional Grey Matter Volume (GMV). The correlation analysis was performed using Statistical Package for the Social Sciences (SPSS) .Results The BN group showed reduced regional grey matter volume of the left medial superior frontal gyrus (SFGmed.L), the right superior temporal gyrus (STG.R), the right median cingulate and paracingulate gyri (DCG.R), the left median cingulate and paracingulate gyri (DCG.L) and the left dorsolateral superior frontal gyrus (SFGdor.L) compared to HC. There was no significantly regional grey matter volume increase in BN patients. The brain areas that GMV altered were uncorrelated with BMI and duration of illness (p>0.05). There was a significantly negtive correlation between age and GMV in the SFGmed.L (P<0.005, r=-0.516), the DCG.R (P<0.005, r=-0.556), the DCG.L (P<0.05, r=-0.576) and the SFGdor.L (P<0.005,r=-0.576). The self-esteem and self-evaluation of BN patients were uncorrelated with the structural alterations of GMV.Conlusions The results show altered regional GMV in females with bulimia nervosa in several brain areas, but it difficult to differentiate whether the GMV changes are the results of BN pathology or the consequences of binge-eating and compensatory behaviour. The structural alterations might be associated with impairments of inhibitory control and body dissatisfaction in BN patients, as well as mood disorder comorbidity.

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Section: Regional Gmv Changescontrasting

confidence: 67%

Altered regional gray matter volume in Chinese female patients with bulimia nervosa

Liu

Wang

et al. 2019

Preprint

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“…Reduced STG volume may cause abnormal body image perception and excessive concern about body shape and weight, leading to restrictive or binge eating. The GMV reduction in the STG in the Japanese study was associated with body dissatisfaction [27]. A functional MRI study has shown deactivation in STG when the individual was thinking about eating food [28].…”

Section: Regional Gmv Alterationsmentioning

confidence: 77%

Altered regional gray matter volume in Chinese female patients with bulimia nervosa

Liu

Wang

et al. 2020

BMC Psychiatry

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Background: Bulimia nervosa (BN) is a psychiatric disorder with unclear pathophysiology. Several studies have associated BN with structural and functional changes in the brain, but findings have been inconsistent. Here we explored this potential association in a small group of Chinese women with BN. Methods: This retrospective study examined 34 women with BN and 34 age-matched healthy controls, all of whom underwent T1-weighted magnetic resonance imaging (MRI). Voxel-based morphometry was carried out to explore alterations in regional grey matter volume (GMV) that may be associated with BN. Results: The BN group showed smaller GMV in the left medial superior frontal gyrus (SFGmed.L), right superior temporal gyrus (STG.R), right median cingulate and paracingulate gyri (DCG.R), left median cingulate and paracingulate gyri (DCG.L) and left dorsolateral superior frontal gyrus (SFGdor.L). No regions showing GMV increases in BN were identified. The GMV reduction did not correlate with body mass index, duration of illness, or patients' self-esteem or overall self-evaluation. GMV reduction correlated negatively with age in the SFGmed. L

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“…[15][16][17] Reduced cortical volumes in AN are related to illness severity and normalize during weight recovery. [18][19][20][21][22][23] Studies that controlled for short-term malnutrition and dehydration found larger left orbitofrontal cortex, as well as right insula volumes, in adolescents and adults with AN. 24,25 The literature on BN is scarcer, and GM structure studies in adolescents or young adults with BED or ARFID are lacking.…”

Section: Gray Matter Volume and Cortical Thicknessmentioning

confidence: 99%

The Neurobiology of Eating Disorders

Frank¹,

Shott²,

DeGuzman³

2019

Child and Adolescent Psychiatric Clinics of North America

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Regional decrease in gray matter volume is related to body dissatisfaction in anorexia nervosa

Cited by 18 publications

References 32 publications

Altered regional gray matter volume in Chinese female patients with bulimia nervosa

Altered regional gray matter volume in Chinese female patients with bulimia nervosa

Altered regional gray matter volume in Chinese female patients with bulimia nervosa

The Neurobiology of Eating Disorders

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