Regional COVID-19 Network for Coordination of SARS-CoV-2 outbreak in Veneto, Italy

Pasin, Laura; Sella, Nicolò; Correale, Christelle; Boscolo, Annalisa; Rosi, Paolo; Saïa, Mario; Mantoan, Domenico; Navalesi, Paolo

doi:10.1053/j.jvca.2020.05.005

Cited by 33 publications

(46 citation statements)

References 10 publications

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“…In our study, SARS-CoV-2 positivity mainly involved males rather than females (72 vs. 18) but no statistical difference emerged, unlikely reported by other authors [ 23 , 24 ]. The average age (65 years) of the SARS-CoV-2-positive dead patients (range from 32 to 81 years) was lower than that of SARS-CoV-2-negative patients (74 years), as also reported in the literature in Italy in the same study period [ 25 , 26 ]. On the contrary, among SARS-CoV-2-positive patients, the older patients more frequently died, likely due to the fact that more often they have co-morbidities [ 27 ].…”

Section: Discussionmentioning

confidence: 54%

Detection of SARS-CoV-2 and Other Infectious Agents in Lower Respiratory Tract Samples Belonging to Patients Admitted to Intensive Care Units of a Tertiary-Care Hospital, Located in an Epidemic Area, during the Italian Lockdown

et al. 2021

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The aim of this study was the detection of infectious agents from lower respiratory tract (LRT) samples in order to describe their distribution in patients with severe acute respiratory failure and hospitalized in intensive care units (ICU) in an Italian tertiary-care hospital. LRT samples from 154 patients admitted to ICU from 27 February to 10 May 2020 were prospectively examined for respiratory viruses, including SARS-CoV-2, bacteria and/or fungi. SARS-CoV-2 was revealed in 90 patients (58.4%, 72 males, mean age 65 years). No significant difference was observed between SARS-CoV-2 positives and SARS-CoV-2 negatives with regard to sex, age and bacterial and/or fungal infections. Nonetheless, fungi were more frequently detected among SARS-CoV-2 positives (44/54, 81.4%, p = 0.0053). Candida albicans was the overall most frequently isolated agent, followed by Enterococcus faecalis among SARS-CoV-2 positives and Staphylococcus aureus among SARS-CoV-2 negatives. Overall mortality rate was 40.4%, accounting for 53 deaths: 37 among SARS-CoV-2 positives (mean age 69 years) and 16 among SARS-CoV-2 negatives (mean age 63 years). This study highlights the different patterns of infectious agents between the two patient categories: fungi were prevalently involved among SARS-CoV-2-positive patients and bacteria among the SARS-CoV-2-negative patients. The different therapies and the length of the ICU stay could have influenced these different patterns of infectious agents.

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Section: Discussionmentioning

confidence: 54%

Detection of SARS-CoV-2 and Other Infectious Agents in Lower Respiratory Tract Samples Belonging to Patients Admitted to Intensive Care Units of a Tertiary-Care Hospital, Located in an Epidemic Area, during the Italian Lockdown

et al. 2021

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“…To reduce pressure on ICUs, ICU beds were almost doubled and sub-intensive care units were activated for non-invasive ventilation treatment of COVID-19 cases with respiratory failure. More details on the hospital system's re-organisation has been described previously [14]. COVID-19 cases were discharged when clinically recovered, even if they still tested positive for SARS-CoV-2.…”

Section: Re-organisation Of Healthcare Servicesmentioning

confidence: 99%

Epidemiology and public health response in early phase of COVID-19 pandemic, Veneto Region, Italy, 21 February to 2 April 2020

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et al. 2020

Eurosurveillance

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Background Veneto was one of the Italian regions hit hardest by the early phase of the coronavirus disease (COVID-19) pandemic. Aim This paper describes the public health response and epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in the Veneto Region from 21 February to 2 April 2020. Methods Information on the public health response was collected from regional health authorities’ official sources. Epidemiological data were extracted from a web-based regional surveillance system. The epidemic curve was represented by date of testing. Characteristics of hospitalised COVID-19 cases were described and compared to those never admitted to hospital. Age- and sex-stratified case-fatality ratios (CFRs) were calculated. Results Key elements of the regional public health response were thorough case-finding and contact tracing, home care for non-severe cases, creation of dedicated COVID-19 healthcare facilities and activation of sub-intensive care units for non-invasive ventilation. As at 2 April 2020, 91,345 individuals were tested for SARS-CoV-2 and 10,457 (11.4%) were positive. Testing and attack rates were 18.6 per 1,000 and 213.2 per 100,000 population, respectively. The epidemic peaked around 20 to 24 March, with case numbers declining thereafter. Hospitalised cases (n = 3,623; 34.6%) were older and more frequently male compared with never-hospitalised cases. The CFR was 5.6% overall, and was higher among males and people > 60 years of age. Conclusion In the Veneto Region, the strict social distancing measures imposed by the Italian government were supported by thorough case finding and contact tracing, as well as well-defined roles for different levels of care.

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“…To the Editor, Hypoxemic acute respiratory failure (hARF) secondary to COVID-19 presents with heterogeneous features depending on several determinants, such as the extent of intravascular microthrombosis, superinfections, and other complications [1,2]. The easiest approach for setting positive end-expiratory pressure (PEEP) and inspiratory oxygen fraction (FiO 2 ) is using PEEP/FiO 2 tables [3,4]. However, because the magnitude of lung recruitability is variable, personalizing PEEP would be desirable [1].…”

mentioning

confidence: 99%

“…EIT optimal PEEP (PEEP EIT ) was defined as the best compromise between lung collapse and overdistension [5]. All patients were deeply sedated without spontaneous breathing efforts and ventilated in volume control mode with lung-protective settings [3]. PEEP EIT was compared with PEEP from higher and lower PEEP/ FiO 2 tables [6].…”

mentioning

confidence: 99%

Positive end-expiratory pressure titration in COVID-19 acute respiratory failure: electrical impedance tomography vs. PEEP/FiO2 tables

et al. 2020

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Regional COVID-19 Network for Coordination of SARS-CoV-2 outbreak in Veneto, Italy

Cited by 33 publications

References 10 publications

Detection of SARS-CoV-2 and Other Infectious Agents in Lower Respiratory Tract Samples Belonging to Patients Admitted to Intensive Care Units of a Tertiary-Care Hospital, Located in an Epidemic Area, during the Italian Lockdown

Detection of SARS-CoV-2 and Other Infectious Agents in Lower Respiratory Tract Samples Belonging to Patients Admitted to Intensive Care Units of a Tertiary-Care Hospital, Located in an Epidemic Area, during the Italian Lockdown

Epidemiology and public health response in early phase of COVID-19 pandemic, Veneto Region, Italy, 21 February to 2 April 2020

Positive end-expiratory pressure titration in COVID-19 acute respiratory failure: electrical impedance tomography vs. PEEP/FiO2 tables

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