Regional cortical thinning in patients with major depressive disorder: A surface-based morphometry study

Tu, Pei Chi; Chen, Li Fen; Hsieh, Jen Chuen; Bai, Yulong; Li, Cheng Ta; Su, Tung Ping

doi:10.1016/j.pscychresns.2011.07.011

Cited by 86 publications

(75 citation statements)

References 67 publications

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“…Right parahippocampal thinning has been observed in BD patients (22) and right fusiform thinning has been observed in a BD cohort (21,23). The few studies investigating cortical thickness in MDD have not detected similar findings (20,24,25,(27)(28)(29)(30)(46)(47)(48), but since they included predominantly medicated and/or older adults, it is likely that age, medication, or duration of illness effects accounted for this discrepancy. In keeping with this, a recent voxel-based morphometry meta-analysis indeed showed that only firstepisode, mainly medication naïve MDD patients have decreased gray matter in a cluster encompassing the right parahippocampal gyrus (10).…”

Section: Discussionmentioning

confidence: 99%

“…Cortical surface area and thickness are also genetically and phenotypically independent (18), but the contribution of cortical thickness toward structural brain abnormalities in mood disorders remains largely unknown. A small number of studies have, however, reported cortical thickness abnormalities in MDD and BD patients in the frontal lobe (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) and superior temporal gyrus (22,23,29,31). Moreover, thickness reductions in the inferior and middle temporal (31), parahippocampal (22), and fusiform gyrus (21,23) have been found in BD.…”

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confidence: 99%

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Cortical Thickness in Individuals at High Familial Risk of Mood Disorders as They Develop Major Depressive Disorder

Papmeyer

Giles

Sussmann

et al. 2015

Biological Psychiatry

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Cortical Thickness in Individuals at High Familial Risk of Mood Disorders as They Develop Major Depressive Disorder

Papmeyer

Giles

Sussmann

et al. 2015

Biological Psychiatry

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“…[26][27][28][29][30] In some of the more recent morphometric MRI studies of MDD, voxel-based methods have been incorporated to allow the detection of brain volume and cortical thickness changes across the entire cerebral volume in an automated fashion, with no need to circumscribe ROIs a priori. Although much less numerous than ROI-based studies, these voxel-based morphometry and cortical thickness studies have provided additional evidence of reduced volumes and thinning of prefrontal, hippocampal, and cingulate regions in association with the presence and severity of MDD symptoms, 28,[31][32][33][34] as well as implicating other brain regions not previously assessed in ROI-based studies of MDD such as the insula. 35 There is evidence that some of the above structural imaging findings reported in MDD samples may be influenced by illness chronicity and treatment effects.…”

Section: Overview Of Structural and Resting-state Functional Neuroimamentioning

confidence: 99%

Structural and Functional Neuroimaging Studies in Major Depressive Disorder With Psychotic Features: A Critical Review

Busatto

2013

Schizophrenia Bulletin

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The relationship between major depressive disorder with psychotic (MDDP) features and schizophrenia has long been recognized, and the neurobiological boundaries between these disorders can nowadays be investigated using neuroimaging techniques. This article provides a critical review of such studies, addressing how they support a dimensional approach to the nosology and pathophysiology of psychotic disorders. A proportion of neuroimaging studies carried out to date indicate that MDDP subjects display structural and functional abnormalities in some brain regions specifically implicated in the pathophysiology of mood disorders, such as the subgenual cingulate cortex. This reinforces the validity of the classification of MDDP in proximity to major depression without psychosis. There is some neuroimaging evidence that MDDP may be associated with additional brain abnormalities relative to nonpsychotic major depression although less prominently in comparison with findings from the neuroimaging literature on schizophrenia. Brain regions seen as critical both to emotional processing and to models of psychotic symptoms, such as the hippocampus, insula, and lateral prefrontal cortex, have been implicated in separate neuroimaging investigations of either schizophrenia or major depression, as well as in some studies that directly compared depressed patients with and without psychotic features. These brain regions are key targets for future studies designed to validate imaging phenotypes more firmly associated with MDDP, as well as to investigate the relationship between these phenotypes and possible etiological influences for MDDP.

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“…A number of structural MRI studies of MDD have shown morphological abnormalities, mainly cortical thickness, gray matter volume, and white matter integrity [12][13][14][15][16][17], particularly in the frontal areas.…”

Section: Mr Imaging Of Brain Morphology and Structurementioning

confidence: 99%

Molecular, Functional, and Structural Imaging of Major Depressive Disorder

Zhang

Zhu

et al. 2016

Neurosci. Bull.

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Major depressive disorder (MDD) is a significant cause of morbidity and mortality worldwide, correlating with genetic susceptibility and environmental risk factors. Molecular, functional, and structural imaging approaches have been increasingly used to detect neurobiological changes, analyze neurochemical correlates, and parse pathophysiological mechanisms underlying MDD. We reviewed recent neuroimaging publications on MDD in terms of molecular, functional, and structural alterations as detected mainly by magnetic resonance imaging (MRI) and positron emission tomography. Altered structure and function of brain regions involved in the cognitive control of affective state have been demonstrated. An abnormal default mode network, as revealed by resting-state functional MRI, is likely associated with aberrant metabolic and serotonergic function revealed by radionuclide imaging. Further multi-modal investigations are essential to clarify the characteristics of the cortical network and serotonergic system associated with behavioral and genetic variations in MDD.

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Regional cortical thinning in patients with major depressive disorder: A surface-based morphometry study

Cited by 86 publications

References 67 publications

Cortical Thickness in Individuals at High Familial Risk of Mood Disorders as They Develop Major Depressive Disorder

Cortical Thickness in Individuals at High Familial Risk of Mood Disorders as They Develop Major Depressive Disorder

Structural and Functional Neuroimaging Studies in Major Depressive Disorder With Psychotic Features: A Critical Review

Molecular, Functional, and Structural Imaging of Major Depressive Disorder

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