Regional clustering and waves patterns due to COVID-19 by the index virus and the lambda/gamma, and delta/omicron SARS-CoV-2 variants in Peru

Toyama, Melissa; Vargas, Lucía; Ticlihuanca, Sofía; Quispe, Antonio M.

doi:10.1016/j.annepidem.2022.08.026

Cited by 4 publications

(17 citation statements)

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“…25 Similarly, a study in China reported that the COVID-19 pandemic might be associated with an increased risk of delayed fine motor (OR: 2.50; 95% CI, 1.25-4.99) and language development (absolute risk difference (RRa): 1.13; 95% CI, 1.02-1.25) in 1-year-old children 26 . In Peru, due to its precarious health system and controversial political decisions, an aggressive and prolonged quarantine was applied in contrast to other countries 27,28 , which may have had a relevant impact on child development in our population since most of them were > 3 years. This could explain, at least in part, the high frequency of delay in the area of hearing and language.…”

Section: Discussionmentioning

confidence: 99%

Developmental delay assessment in children < 5 years of age attended in the Pediatric Rehabilitation Service of a reference hospital in Peru

Cerna-Luna¹,

Fernández-Guzman²,

Alvarado-Gamarra³

et al. 2023

BMHIM

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Background: Child development is a complex biological, psychological, and emotional process. Timely screening for developmental delay allows early interventions. Therefore, this study sought to assess the frequency and characteristics of developmental delay in children < 5 years of age who attended the Pediatric Rehabilitation Service of a referral hospital in Peru. Methods: We conducted a cross-sectional study. Information was collected from medical records of children < 5 years of age who attended between April and September 2022 at the Rebagliati Hospital's Pediatric Rehabilitation Service. The REBA-PED Child Developmental Assessment Profile was used for the developmental assessment, which allows to identify the degree of delay in each area (gross motor, fine motor, hearing and language, intelligence and learning, and personal-social) and the presence of warning signs. Results: Of 226 children who attended the service, 49.1% were between 3 and 5 years old, 57.1% were female, only 3.1% were referred for suspected developmental delay, and none had had a previous developmental assessment. Among the children evaluated, 12.4% had a simple developmental delay, 19.5% had a significant developmental delay, and 53.5% had a global developmental delay. In addition, 70.8% presented a warning sign of developmental delay. Hearing and language (86.8%) and intelligence and learning (83.5%) areas had a higher frequency of significant developmental delay. Conclusions: We found a high frequency of developmental delay in the children assessed, predominantly in hearing and language. Although all the children were referred, none had had a previous developmental assessment.

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Section: Discussionmentioning

confidence: 99%

Developmental delay assessment in children < 5 years of age attended in the Pediatric Rehabilitation Service of a reference hospital in Peru

Cerna-Luna¹,

Fernández-Guzman²,

Alvarado-Gamarra³

et al. 2023

BMHIM

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“…Moreover, in our hospital, we observed a higher impact of critical outcomes with the Lambda variant compared with the Omicron and wild-type virus. The first Lambda cases reported in Peru had an enormous impact on the country's public health ( 22 , 23 ). A study conducted in Poland found no differences in the clinical course between different COVID-19 variants but reported few cases, and COVID-19 variants were not evaluated individually ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

“…During this period, Peru was affected by three COVID-19 waves: the first was from March 2020 to December 2020 and was associated with the wild-type virus; the second wave was from January 2021 to June 2021, with the Lambda variant; and the third wave took place between January and April 2022, with the Omicron variant ( 22 , 23 ).…”

Section: Methodsmentioning

confidence: 99%

Short-, mid-, and long-term complications after multisystem inflammatory syndrome in children over a 24-month follow-up period in a hospital in Lima-Peru, 2020–2022

Alvarado-Gamarra,

Estupiñan-Vigil,

Garcés-Ghilardi

et al. 2023

Front. Pediatr.

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ObjectiveTo determine the short-, mid-, and long-term complications after multisystem inflammatory syndrome in children (MIS-C) over a 24-month follow-up period in a hospital in Lima, Peru, 2020–2022, and to explore differences according to the immunomodulatory treatment received and type of SARS-CoV-2 virus circulating.MethodsAmbispective 24-month follow-up study in children <14 years of age diagnosed with MIS-C at the Hospital Nacional Edgardo Rebagliati Martins (HNERM).ResultsA total of 62 children were admitted with MIS-C. The most common short-term complications and serious events were intensive care unit (ICU) admission, invasive mechanical ventilation (IMV) due to respiratory failure, and shock; predominantly during the second pandemic wave (lambda predominance) and in children that received intravenous immunoglobulin (IVIG) plus a corticosteroid. Two patients died during the first wave due to MIS-C. During prospective follow-up (median of 24 months; IQR: 16.7–24), only 46.7% of patients were followed for >18–24 months. Of the total, seven (11.3%) patients were identified with some sequelae on discharge. Among the 43 remaining children, sequelae persisted in five (11.6%) cases (neurological, hematological, and skin problems). Six patients (13.9%) presented with new onset disease (hematologic, respiratory, neurological, and psychiatric disorders). One patient died due to acute leukemia during the follow-up period. None of them were admitted to the ICU or presented with MIS-C reactivation. Two patients presented persistence of coronary aneurysm until 8- and 24-month post-discharge.ConclusionIn our hospital, children with MIS-C frequently developed short-term complications and serious events during the acute phase, with less frequent complications in the mid- and long-term. More studies are required to confirm these findings.

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“…To cluster the waves into patterns, it was necessary to determine the optimal nu of clusters. This was achieved by calculating the sum of distances between the cluster ter and its members while incrementally increasing the number of clusters from 2 t The 'elbow point' of the value, as determined using the elbow method [35], indicated the decrease of k-means becomes smaller after 6 clusters. As a result, 6 was chosen a optimal number of clusters.…”

Section: Clustering Genomic Waves From 5399 Clinical Samples Using Gsamentioning

confidence: 99%

Improving CNV Detection Performance in Microarray Data Using a Machine Learning-Based Approach

Goh,

Kwon,

Kim

et al. 2023

Diagnostics

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Copy number variation (CNV) is a primary source of structural variation in the human genome, leading to several disorders. Therefore, analyzing neonatal CNVs is crucial for managing CNV-related chromosomal disabilities. However, genomic waves can hinder accurate CNV analysis. To mitigate the influences of the waves, we adopted a machine learning approach and developed a new method that uses a modified log R ratio instead of the commonly used log R ratio. Validation results using samples with known CNVs demonstrated the superior performance of our method. We analyzed a total of 16,046 Korean newborn samples using the new method and identified CNVs related to 39 genetic disorders were identified in 342 cases. The most frequently detected CNV-related disorder was Joubert syndrome 4. The accuracy of our method was further confirmed by analyzing a subset of the detected results using NGS and comparing them with our results. The utilization of a genome-wide single nucleotide polymorphism array with wave offset was shown to be a powerful method for identifying CNVs in neonatal cases. The accurate screening and the ability to identify various disease susceptibilities offered by our new method could facilitate the identification of CNV-associated chromosomal disease etiologies.

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Regional clustering and waves patterns due to COVID-19 by the index virus and the lambda/gamma, and delta/omicron SARS-CoV-2 variants in Peru

Cited by 4 publications

References 0 publications

Developmental delay assessment in children < 5 years of age attended in the Pediatric Rehabilitation Service of a reference hospital in Peru

Developmental delay assessment in children < 5 years of age attended in the Pediatric Rehabilitation Service of a reference hospital in Peru

Short-, mid-, and long-term complications after multisystem inflammatory syndrome in children over a 24-month follow-up period in a hospital in Lima-Peru, 2020–2022

Improving CNV Detection Performance in Microarray Data Using a Machine Learning-Based Approach

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