Regional cerebral glucose metabolism in anorexia nervosa measured by positron emission tomography

Herholzc, K.; Krieg, J.‐C.; Emrich, H. M.; Pawlik, G.; Beil, Curt; Pirke, Karl M.; Pahlv, J.J.; Wagner, Rainer; Wienhard, K.; Ploog, Detlev; Heiss, Wolf‐Dieter

doi:10.1016/0006-3223(87)90128-4

Cited by 87 publications

(47 citation statements)

References 27 publications

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“…Our data are also in line with other studies in eating disorder patients yielding negative results when relating the structural brain alterations to functional parameters such as regional cerebral glucose metabolism or blood flow [Herholz et al, 1987;Krieg et al, 1989a], It is unclear why the decrement in vigilance perfor mance over time was significantly greater in the group with normal VBR values, indicating that this group had a more impaired sustained attention. The effect may be explained by the higher proportion of anorectic patients in the group with abnormal VBR values, supposing that anorectics are more perfectionistic and generally more motivated than bulimics.…”

Section: Discussionsupporting

confidence: 80%

“…Studies measuring brain glucose metabolism and regional cere bral blood flow in anorectic patients found no evidence of an impaired functioning of specific brain areas, al though the CT examinations of most of these patients showed a cerebral 'atrophy' [Herholz et al, 1987;Krieg et al, 1989a], On the other hand, there is some empirical evidence of impaired cognitive performance in both anorexia ner vosa and bulimia nervosa [Fox, 1981;Hamsher et al, 1981;McKay et al, 1986;Laessle et al, 1990]. In the only study in which the size of the external cerebrospinal fluid spaces and the neuropsychological status were si multaneously measured, a significant improvement in average cognitive test performance (i.e concentration, reaction time, perceptual speed) was observed to parallel a decrease in sulcal width after weight gain in anorectic patients [Kohlmeyer et al, 1983].…”

Section: Introductionmentioning

confidence: 99%

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Cerebral Atrophy and Vigilance Performance in Patients with Anorexia nervosa and Bulimia nervosa

Laessle

Krieg²,

Fichter³

et al. 1989

Neuropsychobiology

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The relationship between ventricular size, as a measure of brain atrophy, and performance on a vigilance task was investigated in 39 patients with anorexia or bulimia nervosa during the acute stage of their illness. Compared to normal controls, the patients performed significantly more poorly in the cognitive task. Half of the patients displayed enlarged ventricles. However, the patients with ventricular dilatation did not perform worse in the cognitive test than patients with normally sized ventricles. Other clinical characteristics, such as symptom severity or duration of illness, were also not correlated with ventricular size. These results support the interpretation that cerebral atrophy per se does not have severe consequences on the neuropsychological or psychopathological status in eating disorder patients.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Cerebral Atrophy and Vigilance Performance in Patients with Anorexia nervosa and Bulimia nervosa

Laessle

Krieg²,

Fichter³

et al. 1989

Neuropsychobiology

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“…However, recent work has focused on the identification of a central nervous system dysfunction in eating disorders and has demonstrated abnormal findings in computed tomographic brain scans [1,2], positron emission tomography [3], neurotransmitter [4,5], and neuropeptide levels [6], and brain event-related potentials (ERPs) [7].…”

Section: Introductionmentioning

confidence: 99%

Prolonged P300 Latency in Eating Disorders

Otagaki

Tohoda²,

Osada³

et al. 1997

Neuropsychobiology

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This study investigated event-related potential (ERP) indices of information-processing in eating disorders. ERPs during an auditory two-tone discrimination task were recorded at midline at 3 sites in 28 anorexic patients, 12 low-weight bulimic patients (body mass index (BMI) under 17.5), 12 normal-weight bulimic patients (BMI over 17.5), and 40 control subjects. The P300 latency was significantly prolonged at all sites in both bulimic groups compared with that in controls, and at frontal and central electrode sites in anorexics. In contrast, the P300 amplitude did not differ between these groups at any site. The prolonged P300 latency in eating disorders suggests a task-related slowing of perceptual decisions that reflects their cognitive impairment.

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“…Changes in putamen and caudate nucleus morphology and metabolism have been described in patients suffering from an obsessive-compulsive disorder (OCD; Baxter et al, 1992;Rosenberg, Keshavan, O'Hearn, Dick, & Bagwell, 1997) and in patients suffering from anorexia nervosa (AN; Hebebrand, Siemon, Lutcke, MariB, & Remschmidt, 1993;Herholz et al, 1987). Antiputamen antibodies have been detected in children suffering from neurobehavioral disorders with an OC component (Kiessling, Marcotte, & Culpepper, 1994;Singer et al, 1998).…”

Section: Introductionmentioning

confidence: 96%