Regional Cerebral Glucose Metabolism and Gait Speed in Healthy Community-Dwelling Older Women

Sakurai, Ryota; Fujiwara, Yoshinori; Yasunaga, Masashi; Takeuchi, Rumi; Murayama, Yoh; Ohba, Hiromi; Sakuma, Naoko; Suzuki, Hiroyuki; Oda, Kazuhiro; Sakata, Muneyuki; Toyohara, Jun; Ishiwata, Kiichi; Shinkai, Shoji; Ishii, Kenji

doi:10.1093/gerona/glu093

Cited by 37 publications

(38 citation statements)

References 41 publications

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“…Other neuroimaging studies have linked functional brain networks during rest with single-task gait (Sakurai et al 2014) and dual-task gait (Yuan et al 2015). The first study found that cerebral glucose metabolism in the PFC, PCC, and parietal cortex was associated with single-task gait and these regions were thought to be constitutive parts of the default mode network (Sakurai et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…The first study found that cerebral glucose metabolism in the PFC, PCC, and parietal cortex was associated with single-task gait and these regions were thought to be constitutive parts of the default mode network (Sakurai et al 2014). The second study found that dual-task gait was associated with greater connectivity in dorsolateral prefrontal regions of the left fronto-parietal resting state network (Yuan et al 2015).…”

Section: Discussionmentioning

confidence: 99%

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Gray matter volume and dual-task gait performance in mild cognitive impairment

Doi

Blumen

Verghese

et al. 2016

Brain Imaging and Behavior

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Dual-task gait performance is impaired in older adults with mild cognitive impairment, but the brain substrates associated with dual-task gait performance are not well-established. The relationship between gray matter and gait speed under single-task and dual-task conditions (walking while counting backward) was examined in 560 seniors with mild cognitive impairment (non-amnestic mild cognitive impairment: n = 270; mean age = 72.4 yrs., 63.6 % women; amnestic mild cognitive impairment: n = 290; mean age = 73.4 yrs., 45.4 % women). Multivariate covariance-based analyses of magnetic resonance imaging data, adjusted for potential confounders including single-task gait speed, were performed to identify gray matter patterns associated with dual-task gait speed. There were no differences in gait speed or cognitive performance during dual-task gait between individuals with non-amnestic mild cognitive impairment and amnestic mild cognitive impairment. Overall, increased dual-task gait speed was associated with a gray matter pattern of increased volume in medial frontal gyrus, superior frontal gyrus, anterior cingulate, cingulate, precuneus, fusiform gyrus, middle occipital gyrus, inferior temporal gyrus and middle temporal gyrus. The relationship between dual-task gait speed and brain substrates also differed by mild cognitive impairment subtype. Our study revealed a pattern of gray matter regions associated with dual-task performance. Although dual-task gait performance was similar in amnestic and non-amnestic mild cognitive impairment, the gray matter patterns associated with dual-task gait performance differed by mild cognitive impairment subtype. These findings suggest that the brain substrates supporting dual-task gait performance in amnestic and non-amnestic subtypes are different, and consequently may respond differently to interventions, or require different interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gray matter volume and dual-task gait performance in mild cognitive impairment

Doi

Blumen

Verghese

et al. 2016

Brain Imaging and Behavior

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“…A recent study indicated that regional cerebral metabolic rates of glucose (rCMRglu) in the prefrontal cortex were associated with control of gait speed . Another recent cross‐sectional study reported that slower maximum walking speed was associated with lower rCMRglu in the prefrontal, posterior cingulate, and parietal cortices, independent of major health factors …”

Section: Discussionmentioning

confidence: 99%

One‐Year Change in the Japanese Version of the Montreal Cognitive Assessment Performance and Related Predictors in Community‐Dwelling Older Adults

Suzuki

Kawai

Hirano

et al. 2015

J American Geriatrics Society

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“…While the observed greater activation of the hippocampus is in line with earlier findings [60], indicating that hippocampal metabolism and atrophy are associated with greater step length variability. In contrast, lower glucose uptake in the prefrontal, posterior cingulate, and parietal cortices was associated with slower maximum walking speed and lower cadence at maximum walking speed among 182 community-dwelling women aged 55 to 89 years [61]. This finding indicates that lower neural activation, as opposed to increased neural activation, is associated with poorer gait.…”

Section: Neuronal Activitymentioning

confidence: 99%

Association between Various Brain Pathologies and Gait Disturbance

Wennberg

Savica

Mielke³

2017

Dement Geriatr Cogn Disord

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Background: Approximately 30% of older adults have disrupted gait. It is associated with increased risk of cognitive decline, disability, dementia, and death. Additionally, most older adults present with 1 or more neuropathologies at autopsy. Recently, there has been an effort to investigate the association between subclinical neuropathology and gait. Summary: We reviewed studies that investigated the association between gait and neuropathologies. Although all pathologies reviewed were associated with gait, grey matter atrophy was most consistently linked with poorer gait performance. Studies investigating the association between white matter and gait focused primarily on total white matter. Future research using more parsed regional analysis will provide more insight into this relationship. Evidence from studies investigating neuronal activity and gait suggests that gait disruption is associated with both under- and overactivation. Additional research is needed to delineate these conflicting results. Lastly, early evidence suggests that both amyloid and tau aggregation negatively impact multiple gait parameters, but additional studies are warranted. Overall, there was substantial methodological heterogeneity and a paucity of longitudinal studies. Key Messages: Longitudinal studies mapping changes in different types of neuropathology as they relate to changes in multiple gait parameters are needed to better understand trajectories of pathology and gait.

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Regional Cerebral Glucose Metabolism and Gait Speed in Healthy Community-Dwelling Older Women

Cited by 37 publications

References 41 publications

Gray matter volume and dual-task gait performance in mild cognitive impairment

Gray matter volume and dual-task gait performance in mild cognitive impairment

One‐Year Change in the Japanese Version of the Montreal Cognitive Assessment Performance and Related Predictors in Community‐Dwelling Older Adults

Association between Various Brain Pathologies and Gait Disturbance

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