Regional Cerebral Blood Flow in Obsessive-Compulsive Disordered Patients at Rest

Lucey, James V.; Costa, Durval C.; Blanes, Tomas; Busatto, Geraldo F.; Pilowsky, Lyn S.; Takei, Noriyoshi; Marks, Isaac; Ell, Peter J.; Kerwin, Robert

doi:10.1192/bjp.167.5.629

Cited by 115 publications

(15 citation statements)

References 19 publications

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“…Several previous functional imaging studies of OCD have either not assessed the cerebellum , or used the activity in this region as reference for normalizing the radioactive uptake in other brain areas (Lucey et al, 1995;Rubin et al, 1992). However, a PET study of resting glucose metabolism by Swedo et al (1989) reported increases in right cerebellar activity in a sample of early-onset OCD subjects compared with healthy controls.…”

Section: Discussionmentioning

confidence: 97%

“…Positron emission tomography (PET) studies measuring resting glucose metabolism have reported hyperactivity in the inferior frontal and anterior cingulate cortices, striatum, and thalamus in patients with OCD (Saxena et al, 1998). There are also single photon emission computed tomography (SPECT) reports of increased (Rubin et al, 1992) or reduced (Lucey et al, 1995) resting regional cerebral blood flow (rCBF) involving frontal-striatal-thalamic circuits in OCD. Finally, there are findings of increased rCBF in inferior frontal, anterior cingulate, striatal, and thalamic areas in PET and functional magnetic resonance imaging (MRI) studies performed during the acute provocation of OCS Rauch et al, 1994).…”

Section: Functional Brain Imaging Studies In Adult Ocd Subjectsmentioning

confidence: 97%

See 1 more Smart Citation

Regional Cerebral Blood Flow Abnormalities in Early-Onset Obsessive-Compulsive Disorder: An Exploratory SPECT Study

Busatto

Buchpiguel

Zamignani

et al. 2001

Journal of the American Academy of Child & Adolescent Psych

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103

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Section: Discussionmentioning

confidence: 97%

Section: Functional Brain Imaging Studies In Adult Ocd Subjectsmentioning

confidence: 97%

Regional Cerebral Blood Flow Abnormalities in Early-Onset Obsessive-Compulsive Disorder: An Exploratory SPECT Study

Busatto

Buchpiguel

Zamignani

et al. 2001

Journal of the American Academy of Child & Adolescent Psych

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103

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“…Fewer consistent changes were found in basal ganglia: after normalization of data, only three studies found differences in basal ganglia in patients and healthy individuals in the resting state. Increased glucose m etabolism was found by Benkelfat et al (1990) in the left basal ganglia, using PET and bilaterally decreased rCBF by Rubin et al (1992) and Lucey et al (1995) using SPECT.…”

Section: Functional Im Agingmentioning

confidence: 84%

“…In eight of them (Baxter et al, 1987(Baxter et al, , 1988Benekelfat et al, 1990;Machlin et al, 1991;Nordahl et al, 1989;Rubin et al, 1992;Sawle et al, 1991;Swedo et al, 1989b), metabolism or perfusion was reported to be increased in OCD, while it was decreased in the remaining three (Lucey et al, 1995;M artinot, 1990;Mindus et al, 1986). Fewer consistent changes were found in basal ganglia: after normalization of data, only three studies found differences in basal ganglia in patients and healthy individuals in the resting state.…”

Section: Functional Im Agingmentioning

confidence: 93%

Psychobiology of obsessive-compulsive disorder: anatomical and physiological considerations

Hoehn‐Saric

Greenberg²

1997

International Review of Psychiatry

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Sum m arySeveral models seek to explain the psych obiology of obsessive± com pulsiv e disorder (O CD). W hile none fully explains brain m ech anism s responsible for the psychopathology of OC D, such models, based on clinical and experimenta l studies, elucid ate further direction . This article review s evidence from clinica l observations and from electrophysiological and im aging stud ies on which the models were based. A variety of neurolo gica l diseases that involv e the fronto± striatal and lim bic/paralim bic system s are associated with obsessive and com pulsive sym ptom s. E lectroph ysiological and im aging studies in O CD patients free from dem onstra ble neurolo gical lesions, strongly suggest that these regions are involved in the pathobiology of obsessive± com pulsive disorder. The m ost consiste nt ® ndings in im aging stud ies were increased m eta bolism and blood¯ow in orbito± frontal regions at rest and, in addition, regional changes in the striatum and in lim bic/paralim bic regions during sym ptom provocation . Imaging studies indicate predomina nt prefrontal hyperactiv ity, particularly on the right. Neuroim aging, electrophysiological and neuropsychological stud ies suggest that both hem ispheres may contribute, perhaps to different degrees, to the pathophysiology of OC D. Since OC D is a heterogen eous disorder, it is likely that regionally speci® c pathology in the disorder will be variable.

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“…Finally, Lucey et al (1995), using SPECT, compared 30 OCD patients with 30 healthy control subjects and found decreased metabolic activity in the right caudate nucleus and the right thalamus, as well as in several cortical areas, including the right inferior frontal cortex.…”

Section: Functional Brain Imagingmentioning

confidence: 99%

Issues surrounding the cognitive neuroscience of obsessive-compulsive disorder

Wilson

1998

Psychonomic Bulletin & Review

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Obsessive-compulsive disorder (OCD) has been studied extensively in recent years, with increased emphasis on understanding OCD's biological substrates. There has been significant progress in documenting abnormal brain function in OCD patients, particularly in the orbitofrontal cortex, basal ganglia, and thalamus. Similar progress has broadened our understanding of the cognitive and behavioral manifestations of the disorder, including deficits in set shifting, hyperattention, and visuospatial construction abilities. Unfortunately, these results have not been replicated consistently. This report comprises a review of previous attempts to characterize the neurobiology and neuropsychology of OCD, and a discussion of several factors in OCD research that can help to explain previous inconsistencies.Obsessive-compulsive disorder (OCD) is a relatively common form of psychopathology with a lifetime prevalence of2%-3% (Robins et al., 1984). Although the anatomical and behavioral regularities of the disorder have been studied extensively over the past 20 years, there has been relatively little success in the attempt to establish how the former give rise to the latter. Popular models of OCD have drawn upon a variety of disciplines, including learning theory (Mowrer, 1960), cybernetics (Pitman, 1987) and psychoanalysis (Fenichel, 1945). Often, however, these models have had relatively little to say about the dysfunctional aspects of the OCD brain. This is due in part to the fact that, until recently, the neuroanatomical substrates ofOCD were poorly understood. Although OCD researchers had long suspected the involvement of the frontal cortex and basal ganglia in OCD neuropathology, there was little empirical evidence to support such claims. Only through the use ofmodern neuroimaging techniques have many of these suspicions been confirmed.Neurobiological studies ofOCD have produced a wealth of data, but the inability to consistently replicate results has left many questions unanswered. Neuropsychological studies have similarly generated much information, but with equal uncertainty. An adequate theory ofOCD must integrate the findings from each of these two disciplines, but any such integration would be premature at the moment, given the variability present within each. The goal of this review is therefore not to provide an all-encompassing theory ofOCD expression, but rather to delineate several factors that may explain the discrepancies among previous studies of OCD. Consideration of these factors will help clarify the relevant neurobiological and neuropsycho-

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Regional Cerebral Blood Flow in Obsessive-Compulsive Disordered Patients at Rest

Abstract: rCBF differs significantly between resting OCD patients and healthy controls, and separate clinical dimensions are associated with functionally distinct rCBF patterns.

Cited by 115 publications

References 19 publications

Regional Cerebral Blood Flow Abnormalities in Early-Onset Obsessive-Compulsive Disorder: An Exploratory SPECT Study

Regional Cerebral Blood Flow Abnormalities in Early-Onset Obsessive-Compulsive Disorder: An Exploratory SPECT Study

Psychobiology of obsessive-compulsive disorder: anatomical and physiological considerations

Issues surrounding the cognitive neuroscience of obsessive-compulsive disorder

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