Regional cerebral blood flow in patients with dementia of Alzheimer's type: Relationship to psychiatric symptoms

Galynker, Igor; Vilkas, N.; Dutta, E.; Serseni, D.; Finestone, Howard; Gallagher, R.; Rosenthal, Richard N.

doi:10.1016/0006-3223(96)84479-9

Cited by 3 publications

(2 citation statements)

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“…Using the ROI method, Sabbagh et al [10] could only find total hemisphere hypoperfusion rather than one specific region. Galynker et al [11] and Mega et al [12] both reported reduced perfusion in the prefrontal cortex and cingulate gyrus. Mega et al [12] even specified the anterior part of cingulate gyrus as in our study, but the ventral striatum, pulvinar and dorsolateral parietal cortex are also reported in their study.…”

Section: Discussionmentioning

confidence: 99%

“…Decreased perfusion over the parieto-temporal region in SPECT images has been well demonstrated in AD patients [8,9], and it has become a part of the diagnostic tool in clinical practice. Plenty of SPECT and positron emission tomography (PET) studies discuss the perfusion differences in AD patients with or without delusion, apathy, or other psychotic symptoms [10][11][12][13][14][15][16][17][18][19][20]; yet only a few studies mention the differences between depressed and nondepressed AD patients [10][11][12][13][14][15]. In fact, most of them group different kinds of psychotic symptoms as one variable rather than focusing solely on depression.…”

Section: Introductionmentioning

confidence: 99%

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Selective Hypoperfusion of Anterior Cingulate Gyrus in Depressed AD Patients: A Brain SPECT Finding by Statistical Parametric Mapping

Liao

Liu

Lee

et al. 2003

Dement Geriatr Cogn Disord

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This study tests the hypothesis that depression in patients with Alzheimer’s disease (AD) is due to a specific pathogenesis rather than a reactive phenomenon. Forty-three AD patients received a psychiatrist’s interview, neuropsychological assessments, and a ^99mTc-hexamethyl propyleneamine oxime single photon emission computed tomography (HMPAO-SPECT). Analysis by statistical parametric mapping (SPM) showed that the depressed group had selective hypoperfusion in the bilateral anterior and posterior cingulate gyri and precuneus. Using the Hamilton Depression Rating Scale as a parameter, an inverse correlation was found between cerebral perfusion and the severity of depression. The right anterior cingulate gyrus demonstrated a most significant reduction in perfusion. These locations are akin to the imaging findings in patients with primary depression, indicating a specific pathogenesis for depression in AD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selective Hypoperfusion of Anterior Cingulate Gyrus in Depressed AD Patients: A Brain SPECT Finding by Statistical Parametric Mapping

Liao

Liu

Lee

et al. 2003

Dement Geriatr Cogn Disord

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Evaluation of dysthymic disorder with technetium-99 m hexamethylpropylene amine oxime brain single-photon emission tomography

Sarıkaya

Karaşin

Çermik

et al. 1999

European Journal of Nuclear Medicine and Molecular Imaging

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Dysthymic disorder is a chronic disorder characterised by the presence of a depressed mood and is classified as a distinct category in DSM-IV, separately from major depression. Although brain imaging studies have been performed in major depressive disease, there have to date been no reports of such studies in dysthymic disorder. In this study 36 patients with dysthymic disorder were compared with 16 normal subjects using technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography. A relative blood flow ratio was calculated for each region of interest using the average tissue activity in the region divided by activity in the cerebellum. There were significant differences in the bilateral inferior frontal, bilateral parietal, right superior frontal and left posterior temporal regions in the patients with dysthymic disorder compared with the healthy controls. These findings support the hypothesis that the biological bases for dysthymic disorder and major depression are similar. Recognition of these regional abnormalities may have clinical utility in both the diagnosis and the treatment of dysthymic disorder. Further studies are needed to confirm our results and to assess the influence of treatment in patients with dysthymic disorder.

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Reduced frontal perfusion in depressed postmenopausal women: A SPECT study with WCST

et al. 2008

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Regional cerebral blood flow in patients with dementia of Alzheimer's type: Relationship to psychiatric symptoms

Cited by 3 publications

References 0 publications

Selective Hypoperfusion of Anterior Cingulate Gyrus in Depressed AD Patients: A Brain SPECT Finding by Statistical Parametric Mapping

Selective Hypoperfusion of Anterior Cingulate Gyrus in Depressed AD Patients: A Brain SPECT Finding by Statistical Parametric Mapping

Evaluation of dysthymic disorder with technetium-99 m hexamethylpropylene amine oxime brain single-photon emission tomography

Reduced frontal perfusion in depressed postmenopausal women: A SPECT study with WCST

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