Regional Cerebral Blood Flow in Patients Suffering from Post-Traumatic Stress Disorder

Mirzaei, Siroos; Knöll, Peter; Keck, Andrea; Preitler, B.; Gutiérrez, E.; Umek, H.; Köhn, Horst; Pecherstorfer, Martin

doi:10.1159/000054900

Cited by 30 publications

(18 citation statements)

References 12 publications

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“…Furthermore, no changes were reported in the cerebellum, medial frontal cortex, and thalamus. Mirzaei et al [2001], using the same radiotracer, found an increase in left hemisphere rCBF in patients with PTSD who survived torture episodes. The most recent results, reported by Bonne et al [2003b], using 99m-Tc HMPAO, found decreased activity in the right precentral, superior temporal, and fusiform gyri, accompanied by increased rCBF in the cerebellum.…”

Section: Resting Paradigmsmentioning

confidence: 82%

“…The most straightforward way of measuring brain activity is by observing a subject at rest. In PTSD, researchers have used both PET and SPECT to measure rCBF [Bonne et al, 2003b;Mirzaei et al, 2001;Seedat et al, 2004], glucose metabolism [Bremner et al, 1997], and the binding potentials for both benzodiazepine [Bremner et al, 2000;Fujita et al, 2004] and serotonin 1A [Bonne et al, 2005] receptors. Cerebral blood flow, and both receptor availability and affinity are all indirect measures of activity, or potential activity, in the brain.…”

Section: Functional Neuroimaging Paradigmsmentioning

confidence: 99%

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Functional neuroimaging studies in posttraumatic stress disorder: review of current methods and findings

2007

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Posttraumatic stress disorder (PTSD) is an anxiety disorder associated with changes in neural circuitry involving frontal and limbic systems. Altered metabolism in these brain structures after a traumatic event is correlated to PTSD. Developments in the field of neuroimaging have allowed researchers to look at the structural and functional properties of the brain in PTSD. Despite the relative novelty of functional imaging and its application to the field of PTSD, numerous publications have brought to light several of the circuits implied in this disorder. This article summarizes the findings with regard to PTSD in the functional imaging techniques of singlephoton emission computed tomography (SPECT), positron emission tomography (PET), and functional magnetic resonance imaging (fMRI). Furthermore, we discuss strengths and weaknesses of the various techniques and studies. Finally, we explore the future potential of functional neuroimaging studies in PTSD.

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Section: Resting Paradigmsmentioning

confidence: 82%

Section: Functional Neuroimaging Paradigmsmentioning

confidence: 99%

Functional neuroimaging studies in posttraumatic stress disorder: review of current methods and findings

2007

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“…Only few resting-state imaging studies of PTSD have been performed [62], [63], [64], [65], [66]. The findings are heterogenous and are not restricted to the default mode activity, even though abnormal resting-state activity in some areas of the DMN was observed in PTSD patients compared to healthy controls [62], [66].…”

Section: Methodsmentioning

confidence: 99%

Dissociative Part-Dependent Resting-State Activity in Dissociative Identity Disorder: A Controlled fMRI Perfusion Study

et al. 2014

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BackgroundIn accordance with the Theory of Structural Dissociation of the Personality (TSDP), studies of dissociative identity disorder (DID) have documented that two prototypical dissociative subsystems of the personality, the “Emotional Part” (EP) and the “Apparently Normal Part” (ANP), have different biopsychosocial reactions to supraliminal and subliminal trauma-related cues and that these reactions cannot be mimicked by fantasy prone healthy controls nor by actors.MethodsArterial spin labeling perfusion MRI was used to test the hypotheses that ANP and EP in DID have different perfusion patterns in response to rest instructions, and that perfusion is different in actors who were instructed to simulate ANP and EP. In a follow-up study, regional cerebral blood flow of DID patients was compared with the activation pattern of healthy non-simulating controls.ResultsCompared to EP, ANP showed elevated perfusion in bilateral thalamus. Compared to ANP, EP had increased perfusion in the dorsomedial prefrontal cortex, primary somatosensory cortex, and motor-related areas. Perfusion patterns for simulated ANP and EP were different. Fitting their reported role-play strategies, the actors activated brain structures involved in visual mental imagery and empathizing feelings. The follow-up study demonstrated elevated perfusion in the left temporal lobe in DID patients, whereas non-simulating healthy controls had increased activity in areas which mediate the mental construction of past and future episodic events.ConclusionDID involves dissociative part-dependent resting-state differences. Compared to ANP, EP activated brain structures involved in self-referencing and sensorimotor actions more. Actors had different perfusion patterns compared to genuine ANP and EP. Comparisons of neural activity for individuals with DID and non-DID simulating controls suggest that the resting-state features of ANP and EP in DID are not due to imagination. The findings are consistent with TSDP and inconsistent with the idea that DID is caused by suggestion, fantasy proneness, and role-playing.

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“…Specifically, PTSD patients showed higher cerebral blood flow in the left hemisphere than in the right, most notably in the temporoparietal region [46] and in the projection area of the ventral basal ganglia [47]. …”

Section: Spect Studies Of Regional Cerebral Blood Flowmentioning

confidence: 99%

Molecular Neuroimaging in Posttraumatic Stress Disorder

Namgung

Choi

et al. 2016

Exp Neurobiol

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Over the past decade, an increasing number of neuroimaging studies have provided insight into the neurobiological mechanisms of posttraumatic stress disorder (PSTD). In particular, molecular neuroimaging techniques have been employed in examining metabolic and neurochemical processes in PTSD. This article reviews molecular neuroimaging studies in PTSD and focuses on findings using three imaging modalities including positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance spectroscopy (MRS). Although there were some inconsistences in the findings, patients with PTSD showed altered cerebral metabolism and perfusion, receptor bindings, and metabolite profiles in the limbic regions, medial prefrontal cortex, and temporal cortex. Studies that have investigated brain correlates of treatment response are also reviewed. Lastly, the limitations of the molecular neuroimaging studies and potential future research directions are discussed.

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Regional Cerebral Blood Flow in Patients Suffering from Post-Traumatic Stress Disorder

Cited by 30 publications

References 12 publications

Functional neuroimaging studies in posttraumatic stress disorder: review of current methods and findings

Functional neuroimaging studies in posttraumatic stress disorder: review of current methods and findings

Dissociative Part-Dependent Resting-State Activity in Dissociative Identity Disorder: A Controlled fMRI Perfusion Study

Molecular Neuroimaging in Posttraumatic Stress Disorder

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