Regional cerebral blood flow during acute ischemia Correlation of autoradiographic measurements with observations of cortical microcirculation

Blair, R. D. G.; Waltz, Arthur G.

doi:10.1212/wnl.20.8.802

Cited by 63 publications

(16 citation statements)

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“…These changes have been noted within the same series of animals de spite standardization of the procedures (Blair and Waltz, 1970;Hossmann and Kleihues, 1973;Ta mura et aI., 1980;Kagstr�m et aI., 1983a). Under such experimental conditions, the variations in the resulting acute flow patterns may best be explained by anatomic differences, i.e., the ability of the cere bral circulation to compensate by flow through col lateral channels.…”

Section: Pathophysiological Changes In Ischemiamentioning

confidence: 67%

“…In the studies of Te asdale et al (1981), arteriolar vasoconstriction was shown to occur distal to an occlusion of a major intracerebral vessel, whereas Blair and Waltz (1970) observed both dilatation and constriction of the vessels in the squirrel monkey after occlusion of the middle cerebral artery. It must be assumed that if perfusion pressure drops to near zero values distal to an occlusion, then the smaller vessels collapse.…”

Section: Pathophysiological Changes In Ischemiamentioning

confidence: 96%

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Calcium Antagonist (PY 108-068) Treatment May Further Decrease Flow in Ischemic Areas in Acute Stroke

Vorstrup

Andersen

Blegvad

et al. 1986

J Cereb Blood Flow Metab

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The effect of the possible influence of a new calcium antagonist, PY 108-068, on regional CBF was studied in patients suffering acute ischemic stroke. The dosage was 1.5 + 2.5 mg intravenously in six patients (series 1) and 2.5 + 5.0 mg intravenously in five other patients (series 2). CBF was measured before and after treatment by xenon-133 inhalation and single-photon emission computed tomography (Tomomatic 64). In the first series, no changes in hemispheric CBF, MABP, or clinical symptoms were noted after treatment, but one patient showed an increase of CBF in part of the periin-farct area. In the second series, slight increases in mean hemispheric flow values were seen, but in three of the five patients CBF decreased even further in the ischemic area. MABP decreased by 13%, and the clinical symptoms were unchanged.

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Section: Pathophysiological Changes In Ischemiamentioning

confidence: 67%

Section: Pathophysiological Changes In Ischemiamentioning

confidence: 96%

Calcium Antagonist (PY 108-068) Treatment May Further Decrease Flow in Ischemic Areas in Acute Stroke

Vorstrup

Andersen

Blegvad

et al. 1986

J Cereb Blood Flow Metab

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show abstract

“…Such correlations have been found, 14 ' 1S and a failure to find them might be attributed to techniques that preclude accurate determinations of diameter changes in the smallest pial arterioles.…”

Section: Pial Microcirculationmentioning

confidence: 96%

Editorial

Rosenblum

Kontos

1974

Stroke

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Abstract:The Importance and Relevance of Studies of the Pial Microcirculation • Micropuncture data suggest that pial arterioles contribute only slightly less than parenchyma! cerebral arterioles to total resting cerebrovascular resistance. Care must be taken in interpreting the micropuncture data, or the contribution of pial arterioles to cerebrovascular resistance may be erroneously underestimated. These considerations and the fact that pial arterioles have been shown to be highly reactive to a variety of physiological and abnormal stimuli suggest strongly that changes in pial arteriolar diameter should contribute importantly to control of flow to the underlying brain. In fact, parallels between changes in pial vascular diameter and regional blood flow have been observed. Moreover, since the responses of pial vessels to important vasoactive stimuli are qualitatively similar to those of the cerebral circulation as a whole when the latter are inferred from measurements of flow, the directly observable pial vessels may provide a model for the responses of the unseen parenchyma] segments of the cerebrovascular bed. Such a model would be essential to our understanding of the control of cerebral blood flow, even if pial vessels themselves did not participate in the control of flow. Thus there are multiple reasons for continued study of the pial vessels, particularly with modern techniques developed for microcirculatory investigations.

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“…99 It must be realized, however, that the electrical activity on the surface of the brain may not reveal ischaemia in the deeper regions. 322 Constant attention by trained personnel is required to detect ischaemic changes in the raw EEG. The task of monitoring can be simplified greatly by the use of computer-processed EEG.…”

Section: Monitoring Of Cerebral Perfusionmentioning

confidence: 99%

Perioperative stroke Part I: General surgery, carotid artery disease, and carotid endarterectomy

Wong

1991

Can J Anaesth

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Regional cerebral blood flow during acute ischemia Correlation of autoradiographic measurements with observations of cortical microcirculation

Cited by 63 publications

References 0 publications

Calcium Antagonist (PY 108-068) Treatment May Further Decrease Flow in Ischemic Areas in Acute Stroke

Calcium Antagonist (PY 108-068) Treatment May Further Decrease Flow in Ischemic Areas in Acute Stroke

Editorial

Perioperative stroke Part I: General surgery, carotid artery disease, and carotid endarterectomy

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