Regional cerebral blood flow changes associated with interoceptive awareness in the recovery process of anorexia nervosa

Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa

“…Interestingly, previous single photon emission computed tomography studies have also revealed decreased perfusion, predominantly in the PCC, the pre-and postcentral gyrus, the precuneus and the lateral prefrontal cortex. 4,52 In the present fMRI experiment, a lack of BOLD activation suppression was observed in patients with anorexia nervosa in the PCC during the processing of painful thermal stimuli, indicating disturbed DMN activity. Thus, previous reports 8,51 and our results may point toward the possibility that the observed circumscribed structural deficits might represent the neural basis of the reported functional disturbances.…”

Regional cerebral blood flow after recovery from anorexia or bulimia nervosa

“…7 Normalization of rCBF appears to lag behind weight recovery: ill AN had bilateral cortical hypoperfusion that normalized after 3 months of remission, 5 and weight recovery in AN was shown to be associated with increases in rCBF. 24 In summary, rCBF returns to normal with longterm recovery, and it is unlikely that altered rCBF contributes to altered serotonin or dopamine function 12 or to stimulus-specific fMRI brain activation 13,25,26 in recovered AN or BN individuals.…”

Evidence for Thalamocortical Circuit Abnormalities and Associated Cognitive Dysfunctions in Underweight Individuals with Anorexia Nervosa

“…Neuroimaging research has demonstrated metabolic, morphological, and functional connectivity abnormalities among patients with AN in frontal, temporal, and visual cortical regions, as well as within subcortical structures including the basal ganglia (Amianto et al, 2013;Cowdrey et al, 2014;Delvenne et al, 1995;Husain et al, 1992;Matsumoto et al, 2006;Takano et al, 2001;Yau et al, 2013). Relatively few studies, however, have investigated the thalamus, a subcortical region that, in part, relays output from the basal ganglia to the cortex through parallel corticostriato-thalamo-cortical (CSTC) loops (Alexander and Crutcher, 1990;Haber and Calzavara, 2009;Parnaudeau et al, 2013).…”