Regional cerebral blood flow changes of cortical motor areas and prefrontal areas in humans related to ipsilateral and contralateral hand movement

Kawashima, Ryuta; Yamada, Kenji; Kinomura, Shigeo; Yamaguchi, Tatsuo; Matsui, Hiroki; Yoshioka, Seiro; Fukuda, Hiroshi

doi:10.1016/0006-8993(93)90006-9

Cited by 239 publications

(120 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are in agreement with previously reported findings (Allison et al, 2000;Kawashima et al, 1993). A significant decrease in OEF was observed in the left precentral gyrus and left superior frontal gyrus.…”

Section: Discussionsupporting

confidence: 94%

Changes in Cerebral Blood Flow and Cerebral Oxygen Metabolism during Neural Activation Measured by Positron Emission Tomography: Comparison with Blood Oxygenation Level-Dependent Contrast Measured by Functional Magnetic Resonance Imaging

Ito

Ibaraki

Kanno

et al. 2005

J Cereb Blood Flow Metab

Self Cite

View full text Add to dashboard Cite

The discrepancy between the increases in cerebral blood flow (CBF) and CMRO 2 during neural activation causes an increase in venous blood oxygenation and, therefore, a decrease in paramagnetic deoxyhemoglobin concentration in venous blood. This can be detected by functional magnetic resonance imaging (fMRI) as blood oxygenation level-dependent (BOLD) contrast. In the present study, changes in the cerebral oxygen extraction fraction (OEF) that corresponds to the ratio of CMRO 2 to CBF, and in the BOLD signal during neural activation, were measured by both positron emission tomography (PET) and fMRI in the same human subjects. C 15 O, 15 O 2 , and H 2 15 O PET studies were performed in each subject at rest (baseline) and during performance of a right-hand motor task. Functional magnetic resonance imaging studies were then performed to measure the BOLD signal under the two conditions. During performance of the motor task, a significant increase in CBF and a significant decrease in OEF were observed in the left precentral gyrus, left superior frontal gyrus, right precentral gyrus, right cingulate gyrus, and right cerebellum. A significant positive correlation was observed between changes in the CBF and the BOLD signal, and a significant negative correlation was observed between changes in the OEF and the BOLD signal. This supports the assumption on which BOLD contrast studies during neural activation are based.

show abstract

Section: Discussionsupporting

confidence: 94%

Changes in Cerebral Blood Flow and Cerebral Oxygen Metabolism during Neural Activation Measured by Positron Emission Tomography: Comparison with Blood Oxygenation Level-Dependent Contrast Measured by Functional Magnetic Resonance Imaging

Ito

Ibaraki

Kanno

et al. 2005

J Cereb Blood Flow Metab

Self Cite

View full text Add to dashboard Cite

show abstract

“…Data from the current work and other studies on human subjects also support this point (Weiller et al, 1992;Kawashima et al, 1993;Kim et al, 1993a,b). The reason for the less obvious lateralization in nonprimary motor areas is presumably related to the fact that these areas are less directly involved in motor output, have no monosynaptic motoneuronal connections, and are involved with more general aspects of motor function such as visual guidance (premotor cortex), timing and internal generation (SMA), and higher somatosensory function (superior parietal lobule).…”

Section: Lateralizationsupporting

confidence: 84%

“…Neural recordings in the motor cortex of nonhuman primates (Evarts, 1966;Tanji et al, 1988) and human subjects (Goldring and Racheson, 1971) have shown that about 10% of cells relate to movements on the ipsilateral side of the body. A number of investigators have suggested that activation in ipsilateral motor cortex occurs only during movements of high spatial and temporal complexity (Kawashima et al, 1994a,b;Roland and Zilles, 1996), although this group (Kim et al, 1993a,b) and others (Kawashima et al, 1993;Chen et al, 1997) have documented the existence of ipsilateral control during more simple movement sequences. It is possible that the ipsilateral motor cortex shows more activation during complex motor tasks, yet there was no interaction between task and lateralization in the current study.…”

Section: Lateralizationmentioning

confidence: 99%

Effects of movement predictability on cortical motor activation

Dassonville

Lewis

Zhu

et al. 1998

Neuroscience Research

View full text Add to dashboard Cite

Humans have the ability to make motor responses to unpredictable visual stimuli, and do so as a matter of course on a daily basis. We used functional magnetic resonance imaging (fMRI) to examine the neural substrate of this behavior in six cortical motor areas. We found that five of these areas (premotor, cingulate, supplementary motor area, pre-supplementary motor area, and superior parietal lobule) showed increased activation in association with an unpredictable behavior compared to a predictable one; only the motor cortex remained unchanged. There was also a quantitative relation between the response time and functional activation in the premotor and cingulate cortex. There was less activation across all the motor areas with repetition of the motor tasks. With the exception of the pre-supplementary motor area, all areas were significantly lateralized, with a greater volume of activation in the hemisphere contralateral to the performing hand. In addition, a left hemisphere dominance was found in the activation of motor cortex and supplementary motor areas. Our results suggest that activation in motor areas is differentially and quantitatively related to higher order aspects of motor behavior such as movement predictability.

show abstract

“…None explained the asymmetry found in the present study. We suggest that the lateralization may be a consequence of normal left hemisphere dominance in motor function [Dassonville et al, 1998;Kawashima et al, 1993].…”

Section: Discussionmentioning

confidence: 85%

STN‐stimulation in Parkinson's disease restores striatal inhibition of thalamocortical projection

Geday

Østergaard

Johnsen

et al. 2007

Human Brain Mapping

View full text Add to dashboard Cite

Regional cerebral blood flow changes of cortical motor areas and prefrontal areas in humans related to ipsilateral and contralateral hand movement

Cited by 239 publications

References 52 publications

Changes in Cerebral Blood Flow and Cerebral Oxygen Metabolism during Neural Activation Measured by Positron Emission Tomography: Comparison with Blood Oxygenation Level-Dependent Contrast Measured by Functional Magnetic Resonance Imaging

Changes in Cerebral Blood Flow and Cerebral Oxygen Metabolism during Neural Activation Measured by Positron Emission Tomography: Comparison with Blood Oxygenation Level-Dependent Contrast Measured by Functional Magnetic Resonance Imaging

Effects of movement predictability on cortical motor activation

STN‐stimulation in Parkinson's disease restores striatal inhibition of thalamocortical projection

Contact Info

Product

Resources

About