2013
DOI: 10.1038/jcbfm.2013.197
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Regional Cerebral Blood Flow and Arterial Blood Volume and Their Reactivity to Hypercapnia in Hypertensive and Normotensive Rats

Abstract: Chronic hypertension induces cerebrovascular remodeling, changing the inner diameter and elasticity of arterial vessels. To examine cerebrovascular morphologic changes and vasodilatory impairment in early-stage hypertension, we measured baseline (normocapnic) cerebral arterial blood volume (CBV a ) and cerebral blood flow (CBF) as well as hypercapnia-induced dynamic vascular responses in animal models. All experiments were performed with young (3 to 4 month old) spontaneously hypertensive rats (SHR) and contro… Show more

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Cited by 16 publications
(21 citation statements)
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“…Although perfusion dynamics were altered in the hypertensive group, CBF values in normotensives and hypertensives were comparable. Similar observations have been reported by the CBF quantification with positron emission tomography and a hypertensive animal model . The cerebrovascular autoregulation process can account for this observation.…”
Section: Discussionsupporting
confidence: 89%
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“…Although perfusion dynamics were altered in the hypertensive group, CBF values in normotensives and hypertensives were comparable. Similar observations have been reported by the CBF quantification with positron emission tomography and a hypertensive animal model . The cerebrovascular autoregulation process can account for this observation.…”
Section: Discussionsupporting
confidence: 89%
“…The slightly increased CBV a in our data may demonstrate this compensatory effect in hypertension. In rodent models, on the contrary, reduced arterial blood volume was observed in hypertension . It may have been caused by a change in vascular tone due to long exposure to vasodilatory isoflurane anesthesia during a prolonged experiment …”
Section: Discussionmentioning
confidence: 99%
“…Leoni et al found that 10–12 weeks SHR had a higher basal CBF and lower hypercapnia-induced CBF response than WKY (under 2% isoflurane and graded (1.5–10%) CO2 stimulation for 5 mins 20s) using the ASL-MRI technique (Leoni et al, 2011), whereas Kim et al found SHR had a lower CBF and higher hypercapnia-induced CBF response compared than WKY at 12–16 weeks SHR (under 1% isoflurane and 4% CO 2 stimulation for 30 s) using the same technique (Kim et al, 2014). Our results agreed with some aspects and disagreed with some aspects of both of these studies, which could be attributed in part to different isoflurane or CO 2 inhalation duration.…”
Section: Discussionmentioning
confidence: 99%
“…Basal CBF has been reported to be similar (Wei et al, 1992; Zhou et al, 2009), lower (Grabowski et al, 1993; Lee et al, 2011) or higher (Heinert et al, 1998) than normotensive animals. CBF responses to hypercapnic (i.e., 5% CO 2 ) challenge have also been found to increase (Kim et al, 2014), reduce (Leoni et al, 2011), or remain unchanged (Yamori and Horie, 1977) at similar stages of hypertension. The effects of hypertension on lumen diameters also varied substantially across different studies (Baumbach et al, 1988; Pires et al, 2011; Rigsby et al, 2011; Rigsby et al, 2007).…”
Section: Introductionmentioning
confidence: 96%
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