Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention

Mertz, Howard; Morgan, Victoria L.; Tanner, Gordon; Pickens, David R.; Price, Ronald R.; Shyr, Yu; Kessler, Robert

doi:10.1016/s0016-5085(00)70170-3

Cited by 529 publications

(389 citation statements)

References 23 publications

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“…Human neuroimaging studies have identified the dACC [48,62] and caudate [26] as regions showing the most significant positive correlation of rCBF with patient's reported pain intensity during noxious CRD. Trends of positive correlation have been observed in the prefrontal cortex [26,62], thalamus [62], striatum [62], and supplementary motor cortex [26].…”

Section: Does the Activity In These Regions Correlate With Emg And Bementioning

confidence: 99%

“…To date, the majority of human studies in this field have used distension of the rectosigmoid colon [4,5,8,41,44,48,52,62], stomach [37,69], and esophagus [2,3,9,73]. Activation of the insular and dorsal anterior cingulate cortex (dACC) has been most consistently reported, with other brain regions, including the prefrontal cortex, thalamus and brainstem being reported in some, but not in other studies.…”

Section: Introductionmentioning

confidence: 99%

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Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation

Wang

Bradesi

Maarek³

et al. 2008

Pain

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Preclinical drug development for visceral pain has largely relied on quantifying pseudoaffective responses to colorectal distension (CRD) in restrained rodents. However, the predictive value of changes in simple reflex responses in rodents for the complex human pain experience is not known. Male rats were implanted with venous cannulas and with telemetry transmitters for abdominal electromyographic (EMG) recordings. [ 14 C]-iodoantipyrine was injected during noxious CRD (60 mmHg) in the awake, nonrestrained animal. Regional cerebral blood flow (rCBF)-related tissue radioactivity was quantified by autoradiography and analyzed in the threedimensionally reconstructed brain by statistical parametric mapping. 60-mmHg CRD, compared with controls (0 mmHg) evoked significant increases in EMG activity (267 ± 24% vs. 103 ± 8%), as well as in behavioral pain score (77 ± 6% vs. 3 ± 3%). CRD elicited significant increases in rCBF as expected in sensory (insula, somatosensory cortex), and limbic and paralimbic regions (including anterior cingulate cortex and amygdala). Significant decreases in rCBF were seen in the thalamus, parabrachial nucleus, periaqueductal gray, hypothalamus and pons. Correlations of rCBF with EMG and with behavioral pain score were noted in the cingulate, insula, lateral amygdala, dorsal striatum, somatosensory and motor regions. Our findings support the validity of measurements of cerebral perfusion during CRD in the freely moving rat as a model of functional brain changes in human visceral pain. However, not all regions demonstrating significant group differences correlated with EMG or behavioral measures. This suggests that functional brain imaging captures more extensive responses of the central nervous system to noxious visceral distension than those identified by traditional measures.

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Section: Does the Activity In These Regions Correlate With Emg And Bementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation

Wang

Bradesi

Maarek³

et al. 2008

Pain

View full text Add to dashboard Cite

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“…Abnormal processing of gastric stimuli at the level of the central nervous system can be one of the mechanisms for visceral hypersensitivity revealed in functional dyspepsia patients [9], but the brain loci responsible for gastric pain remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Patients with headache and functional dyspepsia present meal–induced hypersensitivity of the stomach

Pucci

Miceli

et al. 2005

J Headache Pain

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IntroductionFunctional gastrointestinal disorders are frequently characterised by the presence of extra-intestinal symptoms. A survey on irritable bowel syndrome showed that gynaecological, urinary, psychological, dermatological and neurological symptoms were significantly more prevalent in patients than in controls [1]. Headache, in particular, was present in more than 30% of patients suffering from this condition. Although there is no similar evaluation for functional dyspepsia, the presence of headache also in patients suffering from this functional disorder is a common finding in day-today clinical practice. To our knowledge no data are available on the responsible pathophysiological mechanism.A new instrument recently became available, the barostat, which allows the evaluation of both tone modifications of large viscera, such as the stomach and colon, and the evaluation of visceral sensitivity, by the study of sensitivity thresholds to mechanical distention [2]. The application of this new technology to the study of the pathophysiology of functional dyspepsia has made it possible to identify several mechanisms at the basis of the onset of dyspeptic symptoms: for example, it was shown that the onset of post-prandial epigastric pain, belching and weight loss is due to gastric hypersensitivity to distention Abstract Headache is a frequent feature of functional gastrointestinal disorders but there is no data on the responsible pathophysiological mechanism. The aim of this study was to verify whether alteration of post-prandial gastric tone or sensitivity might explain this association. Fourteen patients affected by functional dyspepsia (7 migraine without aura) and 7 healthy volunteers (HV) underwent gastric tone measurement in fasting condition and after the administration of a liquid meal by barostat. Gastric volume (GV) and accommodation were calculated as difference between mean post-prandial and mean fasting volume. Mean postprandial GV increase and fasting perception and discomfort threshold (DTh) were similar among the 3 groups. DTh after meal was lower in dyspeptic headache patients than in HV and dyspeptic without headache patients. Patients with migraine and functional dyspepsia may be characterised by mealinduced hypersensitivity of the stomach.

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“…If the stress becomes chronic, inflamed tissue in the gut will become tender and the gastrointestinal tract itself, hypersensitive. [16][17][18] In such a manner, it is likely that major (and especially early) trauma effectively programs the mind's stress activation system, prompting the affected individual to become hypersensitive and subject to illness as the immune system overloads. 19 Further evidence for this process is provided by the similarities evident among four insufficiently understood "psychosomatic" conditions: migraine headache, fibromyalgia (ie, chronic pain), chronic fatigue, and depression.…”

Section: A Neurobiological Frameworkmentioning

confidence: 99%

Psychosomatic Plasticity: An “Emergent Property” of Personality Research?

Jawer¹

2006

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Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention

Cited by 529 publications

References 23 publications

Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation

Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation

Patients with headache and functional dyspepsia present meal–induced hypersensitivity of the stomach

Psychosomatic Plasticity: An “Emergent Property” of Personality Research?

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