Regional CBF changes in Parkinson’s disease: a correlation with motor dysfunction

Hsu, Jung Lung; Jung, Tzyy Ping; Hsu, Chien Yeh; Hsu, Wei Chih; Chen, Yen Kung; Duann, Jeng Ren; Wang, Han Cheng; Makeig, Scott

doi:10.1007/s00259-006-0360-7

Cited by 33 publications

(28 citation statements)

References 36 publications

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“…4,10,15,16,18,19,24,27) A cerebral blood flow study using technetium-99m hexamethylpropyleneamine oxime SPECT and SPM analysis 5,9,22,23) showed that cerebral blood flow was negatively correlated with the UPDRS part III scores in the parahippocampal gyrus, inferior parietal lobule, anterior cingulated gyrus, postcentral gyrus, and insular area. 1,2,[12][13][14] These observations were consistent with our findings.…”

Section: Discussionsupporting

confidence: 83%

Preoperative Regional Cerebral Blood Flow and Postoperative Clinical Improvement in Patients With Parkinson's Disease Undergoing Subthalamic Nucleus Deep Brain Stimulation

Nagai

Kajita

Maesawa³

et al. 2012

Neurol. Med. Chir.(Tokyo)

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Preoperative regional cerebral blood flow (rCBF) was measured in 92 patients with Parkinson's disease (PD) by iodine-123 N-isopropyl-p-iodoamphetamine single-photon emission computed tomography. Quantitative mapping of rCBF was performed using the stereotactic extraction estimation method. The clinical features of the patients were assessed according to the Unified Parkinson Disease Rating Scale (UPDRS). The correlation between rCBF and improvement in the UPDRS score following surgery was examined. rCBF in the fusiform gyrus, superior and inferior parietal gyri, middle occipital gyrus, superior frontal gyrus, and middle temporal gyrus of the Talairach Daemon Level 3 was significantly correlated with UPDRS part II (off stage) and III (on stage) scores (p º 0.05). rCBF in the middle temporal gyrus (p ＝ 0.00147), medial frontal gyrus (p ＝ 0.00713), and cerebellum (p ＝ 0.048) of the Talairach Daemon Level 3 was significantly greater in 47 patients with À60% improvement of UPDRS part III (off stage) score than in 37 patients with 40-60% improvement. The cutoff value of rCBF, which indicated that À40% improvement in the surgical outcome could be expected, was 38.8 ± 6.2 ml/100 g/min in the frontal lobe. This study indicated that rCBF in patients with PD might be related to their clinical features, suggesting that quantitative mapping of rCBF may be useful for predicting surgical outcome.

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Section: Discussionsupporting

confidence: 83%

Preoperative Regional Cerebral Blood Flow and Postoperative Clinical Improvement in Patients With Parkinson's Disease Undergoing Subthalamic Nucleus Deep Brain Stimulation

Nagai

Kajita

Maesawa³

et al. 2012

Neurol. Med. Chir.(Tokyo)

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“…For example, the performance of novelty seeking in patients with PD correlated with the insular cortical dopamine D2 receptor availability [Kaasinen et al, 2004]. In addition, the regional cerebral blood flow (rCBF) in the insula decreases in PD [Hsu et al, 2007;Kikuchi et al, 2001], and is negatively correlated with the motor UPDRS [Hsu et al, 2007]. It has been suggested that the insular hypoperfusion has a relation with disease severity and participates in motor performance, and is consistent with the extended predictions of the basal ganglia circuit model [Hsu et al, 2007].…”

Section: Cmentioning

confidence: 80%

Functional connectivity of cortical motor areas in the resting state in Parkinson's disease

Wu¹,

Long

Wang

et al. 2010

Human Brain Mapping

181

147

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Parkinson's disease (PD) patients have difficulty in initiating movements. Previous studies have suggested that the abnormal brain activity may happen not only during performance of self-initiated movements but also in the before movement (baseline or resting) state. In the current study, we investigated the functional connectivity of brain networks in the resting state in PD. We chose the rostral supplementary motor area (pre-SMA) and bilateral primary motor cortex (M1) as "seed" regions, because the pre-SMA is important in motor preparation, whereas the M1 is critical in motor execution. FMRIs were acquired in 18 patients and 18 matched controls. We found that in the resting state, the pattern of connectivity with both the pre-SMA or the M1 was changed in PD. Connectivity with the pre-SMA in patients with PD compared to normal subjects was increased connectivity to the right M1 and decreased to the left putamen, right insula, right premotor cortex, and left inferior parietal lobule. We only found stronger connectivity in the M1 with its own local region in patients with PD compared to controls. Our findings demonstrate that the interactions of brain networks are abnormal in PD in the resting state. There are more connectivity changes of networks related to motor preparation and initiation than to networks of motor execution in PD. We postulate that these disrupted connections indicate a lack of readiness for movement and may be partly responsible for difficulty in initiating movements in PD.

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“…Inhibition of inherent response tendencies is, in fact, considered one of the core functions of DLPFC [17,27,32]. Therefore, and in view of the many reports of a dysfunction of DLPFC in PD [3,12,23,41], a disruption of the interplay between the basal ganglia and DLPFC would seem to be the most likely cause of the patients' anticipatory behaviour. This view fits with the observation that the most severe depletion of dopamine occurs in those areas of the caudate that are connected to DLPFC [37].…”

Section: Discussionmentioning

confidence: 94%

Comparison of smooth pursuit eye movement deficits in multiple system atrophy and Parkinson’s disease

et al. 2009

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Because of the large overlap and quantitative similarity of eye movement alterations in Parkinson's disease (PD) and multiple system atrophy (MSA), a measurement of eye movement is generally not considered helpful for the differential diagnosis. However, in view of the pathophysiological differences between MSA and PD as well as between the cerebellar (MSA-C) and Parkinsonian (MSA-P) subtypes of MSA, we wondered whether a detailed investigation of oculomotor performance would unravel parameters that could help to differentiate between these entities. We recorded eye movements during sinusoidal pursuit tracking by means of video-oculography in 11 cases of MSA-P, 8 cases of MSA-C and 27 cases of PD and compared them to 23 healthy controls (CTL). The gain of the smooth pursuit eye movement (SPEM) component exhibited significant group differences between each of the three subject groups (MSA, PD, controls) but not between MSA-P and MSA-C. The similarity of pursuit impairment in MSA-P and in MSA-C suggests a commencement of cerebellar pathology in MSA-P despite the lack of clinical signs. Otherwise, SPEM gain was of little use for differential diagnosis between MSA and PD because of wide overlap. However, inspection of the saccadic component of pursuit tracking revealed that in MSA saccades typically correct for position errors accumulated during SPEM epochs ("catch-up saccades"), whereas in PD, saccades were often directed toward future target positions ("anticipatory saccades"). The differences in pursuit tracking between PD and MSA were large enough to warrant their use as ancillary diagnostic criteria for the distinction between these disorders.

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Regional CBF changes in Parkinson’s disease: a correlation with motor dysfunction

Cited by 33 publications

References 36 publications

Preoperative Regional Cerebral Blood Flow and Postoperative Clinical Improvement in Patients With Parkinson's Disease Undergoing Subthalamic Nucleus Deep Brain Stimulation

Preoperative Regional Cerebral Blood Flow and Postoperative Clinical Improvement in Patients With Parkinson's Disease Undergoing Subthalamic Nucleus Deep Brain Stimulation

Functional connectivity of cortical motor areas in the resting state in Parkinson's disease

Comparison of smooth pursuit eye movement deficits in multiple system atrophy and Parkinson’s disease

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