Regional Brain Volume in Depression and Anxiety Disorders

Tol, Marie-José van; Wee, Nic J.A. van der; Heuvel, Odile A. van den; Nielen, M.; Demenescu, Liliana Ramona; Alemán, André; Renken, Remco; Buchem, Mark A. van; Zitman, Frans G.; Veltman, Dick J.

doi:10.1001/archgenpsychiatry.2010.121

Cited by 341 publications

(238 citation statements)

References 90 publications

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“…Furthermore, overlapping regions of the aMCC are not only sensitive to conflict and performance monitoring, but are also implicated in negative affect, pain, and emotional disorder (Mayberg, 1997;Shackman et al, 2011;van Tol et al, 2010). These results suggest considerable neuroanatomical convergence between the neural structures recruited during prototypical emotional episodes and conflict monitoring.…”

Section: The Neural Integration Of Control and Emotionmentioning

confidence: 82%

The emotive nature of conflict monitoring in the medial prefrontal cortex

Saunders

Lin

Milyavskaya

et al. 2017

International Journal of Psychophysiology

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The detection of conflict between incompatible impulses, thoughts, and actions is a ubiquitous source of motivation across theories of goal-directed action. In this overview, we explore the hypothesis that conflict is emotive, integrating perspectives from affective science and cognitive neuroscience. Initially, we review evidence suggesting that the mental and biological processes that monitor for information processing conflict-particularly those generated by the anterior midcingulate cortex-track the affective significance of conflict and use this signal to motivate increased control. In this sense, variation in control resembles a form of affect regulation in which control implementation counteracts the aversive experience of conflict. We also highlight emerging evidence proposing that states and dispositions associated with acceptance facilitate control by tuning individuals to the emotive nature of conflict, before proposing avenues for future research, including investigating the role of affect in reinforcement learning and decision making.Keywords: emotion; cognitive control; motivation; event-related potentials; negative affect; medial prefrontal cortex;The Emotive Nature of Conflict 3 The emotive nature of conflict monitoring in the medial prefrontal cortexMonitoring performance for goal conflicting thoughts, feelings, and behaviours underlies flexible responding in complex, unpredictable environments. During smoking cessation, for example, quickly detecting impulses (e.g., the desire to smoke) or actions (e.g., picking up a cigarette) that conflict with the goal to quit can signal the need to control behaviour, safeguarding goal progress. Beyond unwanted temptations, conflict is evoked across diverse explanatory frameworks, ranging from high-level dissonant states that emerge when individual's hold multiple inconsistent ideologies, to seemingly lower-level conflicts that occur when stimulus dimensions cue mutually incompatible responses (e.g., Stroop conflict).Underscoring the theoretical ubiquity of conflict, detecting and overcoming some internal conflict or discord is fundamental to multiple seminal perspectives in western philosophy, psychology, and neuroscience (e.g

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Section: The Neural Integration Of Control and Emotionmentioning

confidence: 82%

The emotive nature of conflict monitoring in the medial prefrontal cortex

Saunders

Lin

Milyavskaya

et al. 2017

International Journal of Psychophysiology

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“…One structural MRI study compared four groups of patients with MDD, panic disorder, social anxiety disorder, and comorbid MDD and anxiety. There were reduced volumes of the rostral anterior cingulate cortex in the four patient groups compared with the healthy controls, but compared with the other subgroups, comorbid anxiety and depression did not lead to significant changes in gray matter volume (van Tol et al, 2010). Another study reported that 96 patients with MDD had lower gray matter volume in the right superior and inferior temporal gyrus compared to 49 anxious depression patients (Inkster et al, 2011).…”

Section: Introductionmentioning

confidence: 81%

Cortical thickness and subcortical structure volume abnormalities in patients with major depression with and without anxious symptoms

et al. 2017

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“…DARTEL is a fully deformable registration method that is effectively unconstrained by number of degrees of freedom. It has proven good segmentation and registration accuracy in comparison with other algorithms [19,20].…”

Section: Pre-processing and Segmentationmentioning

confidence: 97%

Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy

Koppelmans

Ruiter

Lijn

et al. 2011

Breast Cancer Res Treat

150

113

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A limited number of studies have associated adjuvant chemotherapy with structural brain changes. These studies had small sample sizes and were conducted shortly after cessation of chemotherapy. Results of these studies indicate local gray matter volume decrease and an increase in white matter lesions. Up till now, it is unclear if non-CNS chemotherapy is associated with long-term structural brain changes. We compared focal and total brain volume (TBV) of a large set of non-CNS directed chemotherapy-exposed breast cancer survivors, on average 21 years post-treatment, to that of a population-based sample of women without a history of cancer. Structural MRI (1.5T) was performed in 184 chemotherapy-exposed breast cancer patients, mean age 64.0 (SD = 6.5) years, who had been diagnosed with cancer on average 21.1 (SD = 4.4) years before, and 368 age-matched cancer-free reference subjects from a population-based cohort study. Outcome measures were: TBV and total gray and white matter volume, and hippocampal volume. In addition, voxel based morphometry was performed to analyze differences in focal gray matter. The chemotherapy-exposed breast cancer survivors had significantly smaller TBV (-3.5 ml, P = 0.019) and gray matter volume (-2.9 ml, P = 0.003) than the reference subjects. No significant differences were observed in white matter volume, hippocampal volume, or local gray matter volume. This study shows that adjuvant chemotherapy for breast cancer is associated with long-term reductions in TBV and overall gray matter volume in the absence of focal reductions. The observed smaller gray matter volume in chemotherapy- 123Breast Cancer Res Treat (2012) 132:1099-1106 DOI 10.1007/s10549-011-1888-1 exposed survivors was comparable to the effect of almost 4 years of age on gray matter volume reduction. These volume differences might be associated with the slightly worse cognitive performance that we observed previously in this group of breast cancer survivors.

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Regional Brain Volume in Depression and Anxiety Disorders

Cited by 341 publications

References 90 publications

The emotive nature of conflict monitoring in the medial prefrontal cortex

The emotive nature of conflict monitoring in the medial prefrontal cortex

Cortical thickness and subcortical structure volume abnormalities in patients with major depression with and without anxious symptoms

Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy

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