Regional brain glucose metabolism is differentially affected by ketogenic diet: a human semiquantitative positron emission tomography

Horowitz, Tatiana; Doche, Emilie; Philip, Mary; Cammilleri, Serge; Suissa, Laurent; Guedj, Éric

doi:10.1007/s00259-023-06156-w

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Like MRS, PET has been used to characterize the cellular effect of KD. A study by Horowitz et al showed globally reduced brain glucose metabolism with KD, confirming the utilization of alternative energy sources with the intervention [ 175 ].…”

Section: Emerging Nutritional Interventions To Promote Early Brain Re...mentioning

confidence: 94%

Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations

Poblete,

Yaceczko,

Aliakbar

et al. 2023

Biomedicines

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Emerging science continues to establish the detrimental effects of malnutrition in acute neurological diseases such as traumatic brain injury, stroke, status epilepticus and anoxic brain injury. The primary pathological pathways responsible for secondary brain injury include neuroinflammation, catabolism, immune suppression and metabolic failure, and these are exacerbated by malnutrition. Given this, there is growing interest in novel nutritional interventions to promote neurological recovery after acute brain injury. In this review, we will describe how malnutrition impacts the biomolecular mechanisms of secondary brain injury in acute neurological disorders, and how nutritional status can be optimized in both pediatric and adult populations. We will further highlight emerging therapeutic approaches, including specialized diets that aim to resolve neuroinflammation, immunodeficiency and metabolic crisis, by providing pre-clinical and clinical evidence that their use promotes neurologic recovery. Using nutrition as a targeted treatment is appealing for several reasons that will be discussed. Given the high mortality and both short- and long-term morbidity associated with acute brain injuries, novel translational and clinical approaches are needed.

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Section: Emerging Nutritional Interventions To Promote Early Brain Re...mentioning

confidence: 94%

Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations

Poblete,

Yaceczko,

Aliakbar

et al. 2023

Biomedicines

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show abstract

“…Brain PET/CT data were acquired from patients and healthy controls as previously reported (9). Semiquantitative voxel-based statistical analyses were conducted to compare (i) brain PET1 and PET2 from long COVID patients to the PET scans of healthy controls in two separate comparisons and (ii) PET1 to PET2 in a paired model.…”

Section: Imaging Protocol and Semiquantitative Analysismentioning

confidence: 99%

Slight recovery of brain metabolic impairment in patients with persistent long COVID: a nine-month follow-up [18F]FDG-PET study

Horowitz,

Dudouet,

Campion

et al. 2024

Preprint

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Purpose A hypometabolic profile involving the limbic areas, brainstem and cerebellum has been identified in long COVID patients via cerebral [18F]fluorodeoxyglucose (FDG)-PET. This study was conducted to evaluate possible recovery of brain metabolism during the follow-up of patients with prolonged symptoms. Methods Fifty-six adults with long COVID who underwent two brain [18F]FDG-PET scans in our department in May 2020–October 2022 were retrospectively analysed and compared to 51 healthy subjects. On average, PET1 was performed 7 (range 3–17) months after acute COVID-19 infection, and PET2 was performed 16 (range 8–32) months after acute infection. PET was performed because of persistent symptoms, including the following conditions: asthenia, cognitive complaints, dyspnoea, and sleep disorders. Whole-brain voxel-based analysis compared PET1 and PET2 from long COVID patients to scans from healthy subjects (p-voxel < 0.001 uncorrected, p-cluster < 0.05 FWE-corrected) and PET1 to PET2 (with the same threshold and with a less constrained threshold of p-voxel < 0.005 uncorrected, p-cluster < 0.05 uncorrected). Results PET1 and PET2 scans revealed hypometabolism in the previously reported profile. The between-group analysis comparing PET1 and PET2 showed minor improvements in the pons and cerebellum (8.4 and 5.2%, respectively, only significant under the less constrained uncorrected p-threshold); for the pons, the improvement was correlated with the PET1-PET2 interval (r = 0.21, p < 0.05). Of the 14,068 hypometabolic voxels identified on PET1, 6,503 were also hypometabolic on PET2 (46%). Of the 7,732 hypometabolic voxels identified on PET2, 6,094 were also hypometabolic on PET1 (78%). Conclusion Subjects with persistent symptoms of long COVID exhibit durable changes in brain metabolism, with only slight improvement 9 months later.

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Persistent brain metabolic impairment in long COVID patients with persistent clinical symptoms: a nine-month follow-up [18F]FDG-PET study

Horowitz,

Dudouet,

Campion

et al. 2024

Eur J Nucl Med Mol Imaging

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Regional brain glucose metabolism is differentially affected by ketogenic diet: a human semiquantitative positron emission tomography

Cited by 4 publications

References 29 publications

Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations

Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations

Slight recovery of brain metabolic impairment in patients with persistent long COVID: a nine-month follow-up [18F]FDG-PET study

Persistent brain metabolic impairment in long COVID patients with persistent clinical symptoms: a nine-month follow-up [18F]FDG-PET study

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