Regional Blood Flow in Experimental Myositis Ossificans: A Microsphere Study in Conscious Rabbits

Hierton, Claës

doi:10.3109/17453678308992870

Cited by 22 publications

(3 citation statements)

References 16 publications

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“…The lesions were analogous to those observed in humans e.g. after local trauma, arthroplasty or neurologic disorders (2,12,13,14,18,19,25). The purpose of the present study was to determine the changes in the periosteum and in the adjacent vastus intermedius muscle during extraskeletal ossification.…”

supporting

confidence: 72%

Bone formation in experimental myositis ossificans

Aho

Aro

Juntunen

et al. 1988

APMIS

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formation in experimental myositis ossificans. Light and electron microscopic study. APMIS 96: 933-940, 1988.The development of ectopic ossification in experimental myositis ossificans of the rabbit thigh was studied. The right hind limb of 25 rabbits was immobilized with the knee in extension. Once a day the limb was passively mobilized for 2-3 minutes. The animals were killed 3,5,7,14,2 1,28 and 35 days after the beginning of the experiment. Specimens for light and electron microscopy were obtained from both hind limbs. Extensive necrosis and fibrosis were observed in the right vastus intermedius muscle during the first week. Proliferation of chondrocytes and osteoblasts with newly formed woven bone and cartilage formation were found in the periosteum within 7 and 14 days after the beginning of the experiment. Intensive enchondral ossification and hard calcified tissue were observed later. It was evident that bone formation in this experimental model started in the periosteum after necrosis of the adjacent skeletal muscle. Therefore the temporal and spatial relationship of traumatic changes in the periosteum and muscle seems important for the development of myositis ossificans.

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supporting

confidence: 72%

Bone formation in experimental myositis ossificans

Aho

Aro

Juntunen

et al. 1988

APMIS

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“…Many reports have shown a causal relationship between tissue trauma and the formation of HO [10], probably related to local vascular disturbance and necrosis [3,9,16]. The effect of these factors is increased with a longer operating time, which has also been shown to be associated with a higher incidence of HO [17,18].…”

Section: Discussionmentioning

confidence: 99%

Heterotopic ossification after total hip arthroplasty

Toom

Haviko

Rips

2001

International Orthopaedics

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We studied 178 patients undergoing total hip arthroplasty (66 men and 112 women) retrospectively, with regard to the incidence and severity of heterotopic ossification and the significance of postoperative prophylaxis with non-steroid anti-inflammatory drugs. The overall incidence of heterotopic ossification was 32% 1 year after surgery. The factors increasing the incidence were male gender, previous arthroplasty of the contralateral hip joint, previous surgery on the hip, absence of preoperative treatment with non-steroidal anti-inflammatory drugs and an operating time of more than 100 min. The incidence of heterotopic ossification was lower in the patients of 0 blood group.Résumé Nous avons étudié la fréquence et la sévérité d'ossification hétérotopique dans 178 cas d'arthroplastie totale de la hanche avec une prophylaxie postopératoire par AINS. Une année après la chirurgie la fréquence totale était de 32%. Les facteurs qui augmentent le risque étaient le sexe masculin, une arthroplastie de la hanche contrelaterale, des antécédents chirurgicaux sur hanche, l'absence de traitement préopératoire par AINS et une durée opératoire de plus de 100 min. La fréquence d'ossification hétérotopique était inférieure chez les patients du groupe sanguin 0. IntroductionHeterotopic ossification (HO) is a significant complication of total hip arthroplasty (THA). An incidence, without prophylaxis, has been reported of between 8% and 90% [1,13]. Two methods of treatment are commonly used, non-steroidal anti-inflammatory agents (NSAID) and irradiation [5]. The aim of this study was to record the incidence and severity of HO after THA and to determine the relevance of risk factors. Materials and methodsThe notes of 178 patients (66 men and 112 women) who underwent THA in the Clinic of Traumatology and Orthopaedics, Tartu University, between 1995 and 1996 were reviewed retrospectively. The requirement for THA was degenerative arthritis in 160 cases, rheumatoid arthritis in nine cases and trauma of the hip in nine. All patients were treated prophylactically with NSAIDs up to 30 days postoperatively. All patients also received antithrombotic prophylaxis with 0.3 ml (2500 IU) fractioned heparine (Fraxiparine) daily. The prostheses used were all cemented; Lubinus IP in 120 cases, Lubinus SP II in 51 cases and the Link Dysplasia hip prosthesis in seven. In all cases the posterolateral approach was used.The data collected included age, gender, diagnosis, surgery on the ipsi-and contralateral hip performed before or after THA, the operating time, the type of anaesthesia, blood loss and preoperative treatment with NSAIDs. The preoperative anteroposterior radiographs were reviewed, and those taken on the 1st postoperative day and at 3, 6, 9 and 12 months postoperatively, and were assessed according to the Brooker classification, in which HO is classified at stages I-IV, of which stages III and IV are clinically and functionally significant [4].The analysis of preoperative radiographs included the assessment of osteophytes and the s...

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“…This model appears to be more realistic in approximating the clinical setting of HO than other models which use implantation of demineralized bone matrix [25]. The first macroscopic and microscopic tissue changes observed for this model are small hematomas after about 1 wk of forcible mobilization [27]; then muscular edema and necroses ensue, with infiltration of polymorphonuclear leukocytes into the necrotic areas [23]. Neoformation of capillaries and granulation tissue follows.…”

Section: Discussionmentioning

confidence: 96%