Regional blood flow in anemia.

Grupp, Ingrid L.; Grupp, Günter; Holmes, J C; Fowler, Noble O.

doi:10.1152/jappl.1972.33.4.456

Cited by 30 publications

(24 citation statements)

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“…Apparently, the reductions of haematocrit during volume expansion with dextran and during isovolaemic anaemia were compensated for by an increase in renal blood flow. The renal blood flow response to isovolaemic anaemia was considerably larger than that observed in previous studies in dogs (Grupp et al 1972;Fan et al 1980). These latter experiments were made, however, during anaesthesia, which is well known to have major effects on renal haemodynamics.…”

Section: Discussionmentioning

confidence: 68%

Modulation of erythropoietin formation by changes in blood volume in conscious dogs.

Ehmke

Just

Eckardt

et al. 1995

The Journal of Physiology

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1. A possible influence of the filling of the circulatory system on the plasma concentration of erythropoietin, which is the major regulator of erythrocyte formation, was investigated in conscious dogs. 2. Over an experimental period of 5 h, the animals were subjected to either haemorrhage (hypovolaemia), blood volume expansion (hypervolaemia), or exchange transfusion of blood with dextran (isovolaemic anaemia). 3. A reduction of blood volume by 20 % induced by haemorrhage increased plasma erythropoietin levels -1 5-fold in the absence of significant changes in haematocrit. 4. An expansion of blood volume by 12 % induced by an intravenous infusion of dextran did not change plasma erythropoietin levels, although the haematocrit decreased by 0 04. 5. A reduction of the haematocrit by 0-12 in the absence of changes in blood volume induced by an isovolaemic exchange transfusion (dextran vs. blood) increased plasma erythropoietin levels -3-fold. 6. 7.Total renal oxygen supply did not change in any of the three experimental protocols. These data indicate that in dogs the erythropoietin production rate is modulated by changes in blood volume, and suggest a possible role of erythropoietin in the regulation of blood volume.The cardiovascular system responds very sensitively to small alterations in blood volume. Studies in dogs have shown that an expansion of blood volume by less than 10 % caused by an elevated renal reabsorption of fluid is sufficient to raise blood pressure by 20-30 mmHg within a few days

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Section: Discussionmentioning

confidence: 68%

Modulation of erythropoietin formation by changes in blood volume in conscious dogs.

Ehmke

Just

Eckardt

et al. 1995

The Journal of Physiology

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“…The two organs with the highest metabolic rates for oxygen (heart and brain) experience a disproportional increase in blood flow relative to the cardiac output increment, while relatively lower flow is directed to other ''less-vital'' organs (kidney, liver, intestine). 43,62,79 The overall pattern reflects organ specific redirection of the limited blood O 2 content to the organs that are of greatest importance for immediate survival. These responses may be attributed to changes in whole blood viscosity.…”

Section: Systemic B-blockade Inhibits Cardiovascular Responses and Immentioning

confidence: 99%

Reassessing the risk of hemodilutional anemia: Some new pieces to an old puzzle

Tsui

Dattani

Marsden

et al. 2010

Can J Anesth/J Can Anesth

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“…In general, lowered haema-tocrits are associated with redltced vascular resistance and, probably because of this, to increased cardiac output without increase in heart rate, but with alterations in regional blood flow. During isovolaemic haemodilution the proportion of cardiac output entering the coronary circulation increases [33,34] while the proportion entering the renal circulation decreases [35]. Rate of renal blood flow has been reported as decreased [36] or increased [35,37].…”

Section: Blood Viscosity and Renal Functionmentioning

confidence: 99%

“…During isovolaemic haemodilution the proportion of cardiac output entering the coronary circulation increases [33,34] while the proportion entering the renal circulation decreases [35]. Rate of renal blood flow has been reported as decreased [36] or increased [35,37]. In the latter circumstances reduction of filtration fraction has been noted [13,37].…”

Section: Blood Viscosity and Renal Functionmentioning

confidence: 99%

A Hypothesis Proposing Increased Blood Viscosity as a Cause of Proteinuria and Increased Vascular Permeability

Simpson¹

1982

Nephron

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Currently accepted concepts of renal and vascular physiology are inadequate to explain the reversible increases in vascular permeability which occur during episodes of increased blood viscosity. On the basis that all basement membranes exhibit biological thixotropy, it has been suggested that basement membranes are pressure dependent. The physiological significance of increased blood viscosity lies in the associated increase in peripheral vascular resistance which develops because of altered blood rheology. In order to overcome the peripheral resistance, intravascular pressure rises, and if adequate pressures develop, plasma proteins may deform and pass through the vascular basement membrane. This is considered to be the mechanism of proteinuria. In the treatment of high blood viscosity disorders it is suggested that the immunosuppressant drug, Thiamphenicol, may be useful because of its ability to induce a reversible dose-related depression of erythropoiesis, and thereby reduce blood viscosity.

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Regional blood flow in anemia.

Cited by 30 publications

References 0 publications

Modulation of erythropoietin formation by changes in blood volume in conscious dogs.

Modulation of erythropoietin formation by changes in blood volume in conscious dogs.

Reassessing the risk of hemodilutional anemia: Some new pieces to an old puzzle

A Hypothesis Proposing Increased Blood Viscosity as a Cause of Proteinuria and Increased Vascular Permeability

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