Regional blood flow and vascular resistance in the spontaneously hypertensive rat

Tobia, Alfonso J.; Lee, Jang Y.; Walsh, Gerald M.

doi:10.1093/cvr/8.6.758

Cited by 23 publications

(12 citation statements)

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“…As previously shown (Ferrone, Heran & Antonaccio, 1980;Giudicelli et al, 1980;Koike, Katsuaki, Miyamoto & Nishino, 1980;Giudicelli etal., 1981), both drugs exert their preventive effect mainly by opposing the progressive increase in peripheral resistance which normally develops in SHRs during their growth (Tobia, Lee & Walsh, 1974). However, after treatment ceased while blood pressure of previously captopril-treated SHRs is still significantly lower than in controls up to 7 weeks after treatment withdrawal, in the previously dihydralazine-treated SHRs blood pressure is at the same time no longer significantly different from that of controls.…”

Section: Discussionmentioning

confidence: 99%

Compared myocardial and vascular effects of captopril and dihydralazine during hypertension development in spontaneously hypertensive rats

Freslon

1983

British J Pharmacology

137

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1 When administered to young spontaneously hypertensive rats (SHRs), dihydralazine (25 mg kg-', daily) and captopril (100mg kg-, daily) prevent with the same efficacy genetic hypertension development (GHD). 2 Dihydralazine treatment increased vascular mesenteric compliance, as shown by a significant decrease in the stiffness of the vessels (-27%), and induced slight reductions in contractility (-12%) and in wall to lumen (W/L) ratio (-15%). After treatment withdrawal, all these parameters returned to control values within 7 weeks, as did blood pressure. 3 Captopril treatment also strongly increased the mesenteric vessels compliance, vessel stiffness being decreased by 16%, and reduced their contractility (-15%) and their W/L ratio (-30%). These effects as well as those exerted on blood pressure persisted up to 7 weeks after treatment ceased although there was a slight trend to a progressive reduction in the intensity of both phenomena. 4 These experiments show that captopril but not dihydralazine has a long-lasting effect in opposing the functional and morphological vascular alterations occurring during GHD in SHRs and this phenomenon probably contributes to a large extent to the sustained preventive effects of the drug against GHD.

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Section: Discussionmentioning

confidence: 99%

Compared myocardial and vascular effects of captopril and dihydralazine during hypertension development in spontaneously hypertensive rats

Freslon

1983

British J Pharmacology

137

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“…Studies such as those by Ferrone et al 2 and Tobia et al 3 have demonstrated that virtually all organ systems experience an increase in vascular resistance that contributes to hypertension while possibly protecting the smallest vessels of the microvasculature from high pressure. As will be subsequently discussed, the microvascular characteristics in the skeletal muscle and intestine are sufficiently different in the SHR to conclude that a common form of microvascular adaptation in the various organs of spontaneously hypertensive rats may not exist.…”

Section: Discussionmentioning

confidence: 99%

“…1 However, Ferrone et al 2 and Tobia et al 3 have shown that, during hypertension, the majority of organ vasculatures develop increased vascular resistance equal in proportion to that of skeletal muscle. In view of the diversity of microvascular functions and anatomical arrangements among the organs, it is difficult to extrapolate known characteristics of the hypertensive skeletal muscle vasculature to other organ systems.…”

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confidence: 99%

Intestinal microvascular adaptation during maturation of spontaneously hypertensive rats.

Bohlen¹

1983

Hypertension

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SUMMARY Adaptive microvascular changes to increased arterial pressure were investigated in the intestine of spontaneously hypertensive rats (SHR). In 4-to 5-week-old normal Wistar-Kyoto (WKY) and SHR rats, as well as in 18-to 21-week-old WKY rats, the number of arterloles of a given type per milligram of tissue were very similar. However, 18-to 21-week-old SHR had 30% to 35% fewer arterioles in the diameter range of 25-3*5 /A, as if intestinal vessels were lost or failed to grow during maturation. The largest and smallest arterioles in the intestine of adult SHR were constricted by 20% to 25%, but other vessels in the SHR had an equal or increased diameter relative to those in WKY rats. As a result of rarefaction and selective vasoconstriction in SHR, microvascular pressures in the intestinal muscle of SHR were near those in WKY rats, and those in villi of SHR were equal to those in WKY rats despite a 60% to 70% increase in mean arterial pressure in SHR. The percentage of small arterioles (<15 /x) that were intermittently closed to flow at rest was minimal, and the total number of small vessels per milligram of tissue was equal in WKY and SH rats. These data indicate that the adaptive changes in the intestinal vasculature of SHR do not include the loss of small arterioles as occurs in skeletal muscle but that the vascular branching pattern is disturbed, and the largest and smallest arterioles are constricted in the intestine of SHR. (Hypertension 5: 739-745, 1983)

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“…Earlier reports that the resting blood flow in rat hindlimb 27 and spinotrapezius" muscles is near normal in adult SHR suggest that at least the blood flow contribution to tissue oxygenation would favor a near-normal mean tissue P02. In addition, Gray 28 has shown that the anatomical capillary density in the SHR spinotrapezius muscle is normal in animals slightly younger than those used in the current study.…”

Section: -24mentioning

confidence: 92%

Arteriolar diameter and tissue oxygen tension during muscle contraction in hypertensive rats.

Boegehold

Bohlen

1988

Hypertension

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Regional blood flow and vascular resistance in the spontaneously hypertensive rat

Cited by 23 publications

References 0 publications

Compared myocardial and vascular effects of captopril and dihydralazine during hypertension development in spontaneously hypertensive rats

Compared myocardial and vascular effects of captopril and dihydralazine during hypertension development in spontaneously hypertensive rats

Intestinal microvascular adaptation during maturation of spontaneously hypertensive rats.

Arteriolar diameter and tissue oxygen tension during muscle contraction in hypertensive rats.

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