Regional anesthesia and prostate cancer recurrence

Sessler, Daniel I.

doi:10.1007/s12630-009-9222-7

Cited by 7 publications

(1 citation statement)

References 28 publications

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“…Such a stress is perceived as inducing immunoinhibition or immuno-suppression thus theoretically can contribute to progression of the neoplasm. Regional anesthesia also decreases the need for perioperative opioids, which are believed to have a protumoral effect [14,15]. In addition, studies on bupivacaine suggest that it has direct anti-neoplastic properties via activation of both intrinsic and extrinsic apoptotic pathways in ovarian cancer and the intrinsic pathway in prostate cancer [16].…”

Section: The Effect Of Regional Anesthesia On Cancer Recurrencementioning

confidence: 99%

Anesthetic Considerations for Management of Cancer Patients to Decrease Cancer Recurrence

Laudański¹,

Wei²,

Korley³

2016

J Anesth Clin Res

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Alongside the known direct, short-term effects of anesthesia in general, there is emerging evidence of an immunomodulatory effect with specific anesthetics that may decrease patient's defences against malignant neoplastic growths. This effect is especially important in the setting of surgical management of neoplasms, which is often the best option for long-term survival in patients with solid neoplasm. Many studies have speculated on the best anesthetic technique to reduce the neoplasm recurrence and promote patient survival, however, we often neglect the sympathetic stress response to neoplasia and how anesthetics modulate this effect. In this review, we study the evidence as it pertains to anesthetic techniques and pain control, particularly general vs. regional anesthesia, and opioid analgesia. At this time there is not enough evidence to support that regional anesthesia has a more favorable outcome than general anesthesia, or that opioids should not be used in neoplasm-related pain management because of their potential pro-metastatic properties secondary to opioid-induced immunosuppression. Instead, the debate over anesthetic use should be centered on adequate pain control since overwhelming evidence have shown that pain-related stress reaction mediated via β-adrenergic activation, promotes neoplastic propagation and metastasis, hence decreasing survival rates.

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Section: The Effect Of Regional Anesthesia On Cancer Recurrencementioning

confidence: 99%