Regional and temporal awareness of alpha-gal allergy: An infodemiological analysis using Google Trends

Iglesia, Edward G.A.; Stone, Cosby A.; Flaherty, Mary Grace; Commins, Scott P.

doi:10.1016/j.jaip.2019.12.003

Cited by 9 publications

(8 citation statements)

References 9 publications

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“…The authors found the highest search volumes in Sweden, the United States, Canada, Australia, and South Africa. 42 In Southern Africa, the mechanism of sensitization is still not entirely clear, but may be secondary to tick bite, as alpha-gal glycoproteins have been identified in regionally endemic ticks, 43 or to other alpha-gal-bearing endoparasites. 43,44 The prevalence of alpha-gal sensitization varies depending on the region of the world, population studied, and the cutoff value for a positive alpha-gal IgE level.…”

Section: Epidemiology and Diagnosis Epidemiologymentioning

confidence: 99%

The Meat of the Matter: Understanding and Managing Alpha-Gal Syndrome

Macdougall¹,

Thomas²,

Iweala³

2022

ITT

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Alpha-gal syndrome is an unconventional food allergy, characterized by IgE-mediated hypersensitivity responses to the glycan galactose-alpha-1,3-galactose (alpha-gal) and not to a food-protein. In this review, we discuss how alpha-gal syndrome reframes our current conception of the mechanisms of pathogenesis of food allergy. The development of alpha-gal IgE is associated with tick bites though the possibility of other parasites promoting sensitization to alpha-gal remains. We review the immune cell populations involved in the sensitization and effector phases of alpha-gal syndrome and describe the current understanding of why allergic responses to ingested alpha-gal can be delayed by several hours. We review the foundation of management in alpha-gal syndrome, namely avoidance, but also discuss the use of antihistamines, mast cell stabilizers, and the emerging role of complementary and alternative therapies, biological products, and oral immunotherapy in the management of this condition. Alpha-gal syndrome influences the safety and tolerability of medications and medical devices containing or derived from mammalian products and impacts quality of life well beyond food choices.

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Section: Epidemiology and Diagnosis Epidemiologymentioning

confidence: 99%

The Meat of the Matter: Understanding and Managing Alpha-Gal Syndrome

Macdougall¹,

Thomas²,

Iweala³

2022

ITT

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“…Google Trends is a commonly used tool for addressing online health issues. Infodemiological methods using Google Trends can estimate the epidemiological characteristics, explore the public interest, and monitor the dynamic variations in infectious diseases ( 9 ). Previously, some studies demonstrated positive correlations between the online search frequency of “melanoma” and that of its risk factors ( 10 – 12 ).…”

Section: Introductionmentioning

confidence: 99%

Research Interest and Public Interest in Melanoma: A Bibliometric and Google Trends Analysis

et al. 2021

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IntroductionMelanoma is a severe skin cancer that metastasizes quickly. Bibliometric analysis can quantify hotspots of research interest. Google Trends can provide information to address public concerns.MethodsThe top 15 most frequently cited articles on melanoma each year from 2015 to 2019, according to annual citations, were retrieved from the Web of Science database. Original articles, reviews, and research letters were included in this research. For the Google Trends analysis, the topic “Melanoma” was selected as the keyword. Online search data from 2004 to 2019 were collected. Four countries (New Zealand, Australia, the United States and the United Kingdom) were selected for seasonal analysis. Annual trends in relative search volume and seasonal variation were analyzed, and the top related topics and rising related topics were also selected and analyzed.ResultsThe top 15 most frequently cited articles each year were all original articles that focused on immunotherapy (n=8), omics (n=5), and the microbiome (n=2). The average relative search volume remained relatively stable across the years. The seasonal variation analysis revealed that the peak appeared in summer, and the valley appeared in winter. The diseases associated with or manifestations of melanoma, treatment options, risk factors, diagnostic tools, and prognosis were the topics in which the public was most interested. Most of the topics revealed by bibliometric and Google Trends analyses were consistent, with the exception of issues related to the molecular biology of melanoma.ConclusionThis study revealed the trends in research interest and public interest in melanoma, which may pave the way for further research.

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“…8 Therefore, infodemiological methods are becoming more and more competitive to estimate the disease epidemiological characteristics, to explore the public awareness of the management and treatment, and especially to detect and monitor the public interest of the disease. 9 Currently, the most frequently used tool in addressing health issues related to Internet data is Google Trends. Researchers have conducted a lot of research using Google Trends in the rheumatology and immunology area, including systemic lupus erythematosus, 10 rheumatoid arthritis, 11 and multiple sclerosis.…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, patients increasingly use the Internet to search for health‐related information, which may influence medical decision‐making 8 . Therefore, infodemiological methods are becoming more and more competitive to estimate the disease epidemiological characteristics, to explore the public awareness of the management and treatment, and especially to detect and monitor the public interest of the disease 9 …”

Section: Introductionmentioning

confidence: 99%

Public interest in Raynaud's phenomenon: A Google Trends analysis

Wang

Zhang

Zheng

et al. 2020

Dermatologic Therapy

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Raynaud's phenomenon is a common disorder affecting body extremities and other vascular beds. As infodemiological methods have developed, online search tools could be used to explore the public interest of the disease. The study aimed to determine the annual trend, seasonal pattern, and associated topics of Raynaud's phenomenon. Google Trends was used to collect the data. "Raynaud syndrome" was selected as the search term. Data on monthly relative search volume (RSV) were collected from four selected countries (United States, United Kingdom, Australia, and New Zealand) and globally. Related topics were obtained, and annual-related topics were also collected for analysis. The maximum RSV appeared in January 2019, and the minimum value was observed in August 2011. The peak for RSV occurred in winter, and the bottom appeared in summer. In top related topics, "Maurice Raynaud" was the most related. In rising related topics, disease manifestations and autoimmune connective diseases were highly concerned. For annual-related topics, associated diseases were attracting more attention over time. The population is interested in related diseases, pathogenesis, and treatment. There was a peak in winter for searching and supported the importance of season variation on the impact of Raynaud's phenomenon.

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Regional and temporal awareness of alpha-gal allergy: An infodemiological analysis using Google Trends

Cited by 9 publications

References 9 publications

The Meat of the Matter: Understanding and Managing Alpha-Gal Syndrome

The Meat of the Matter: Understanding and Managing Alpha-Gal Syndrome

Research Interest and Public Interest in Melanoma: A Bibliometric and Google Trends Analysis

Public interest in Raynaud's phenomenon: A Google Trends analysis

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