Regional Analysis of the Magnetization Transfer Ratio of the Brain in Mild Alzheimer Disease and Amnestic Mild Cognitive Impairment

Abstract

BACKGROUND AND PURPOSE:Manually drawn VOI-based analysis shows a decrease in magnetization transfer ratio in the hippocampus of patients with Alzheimer disease. We investigated with whole-brain voxelwise analysis the regional changes of the magnetization transfer ratio in patients with mild Alzheimer disease and patients with amnestic mild cognitive impairment.

Myelin content changes in probable Alzheimer's disease and mild cognitive impairment: Associations with age and severity of neuropsychiatric impairment

“…As in the case of myelin‐behavior associations described above, these indirect effects of age on memory capacity displayed the expected domain specificity. These results extend previous findings of age‐related reductions in FA and MTR in both healthy elders and MCI patients.…”

Magnetization transfer in lamellar liquid crystals

“…Application of an MT preparation pulse increases image contrast for tissue in regions where water is efficiently coupled to the semisolid component. The ratio of the difference image to the image obtained without MT preparation, termed magnetization transfer ratio (MTR), is used in clinical research to increase lesion conspicuity without exogenous contrast agents . Several clinical MT studies have been performed primarily in neurological applications in disease such as multiple sclerosis , Alzheimer's disease (AD) , and focal cortical dysplasia in children .…”

“…The ratio of the difference image to the image obtained without MT preparation, termed magnetization transfer ratio (MTR), is used in clinical research to increase lesion conspicuity without exogenous contrast agents . Several clinical MT studies have been performed primarily in neurological applications in disease such as multiple sclerosis , Alzheimer's disease (AD) , and focal cortical dysplasia in children . Other studies indicate that MTR is correlated with tissue fibrosis and could be used to distinguish between inflammation and fibrosis in Crohn's disease .…”

Gender, age‐related, and regional differences of the magnetization transfer ratio of the cortical and subcortical brain gray matter

“…The study was based on a sample of 128 healthy subjects (62 women and 66 men; age range 25.6–88.7 years; mean age 57.6 ± 19.3) composed of individuals recruited as controls for two prospective studies investigating the capability of MT imaging to detect and track microstructural changes of cortical and subcortical GM in subjects with presymptomatic and early Huntington's disease and patients with Alzheimer's disease or mild cognitive impairment . None of the control subjects had a personal or familial history of neurological diseases or had experienced episodes of neurological or psychiatric dysfunction.…”