Regional Analgesia in Intensive Care Unit

Hajiesmaeili, Mohammadreza; Motavaf, Mahsa; Safari, Saeid

doi:10.5812/aapm.10587

Cited by 4 publications

(3 citation statements)

References 17 publications

(25 reference statements)

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“…Occurrence of hepatic injury following desflurane anesthesia was once thought to be rare. However, case reports reporting complications related to the use of this anesthetic continue to be accumulated ( 30 - 35 ). Interestingly, in addition to circulating anti-TFA antibodies ( 4 , 5 ), such as those associated with halothane or isoflurane, recently autoantibodies to CYP2E1 and 58 kDa endoplasmic reticulum protein (ERp58), have been reported after desflurane anesthesia ( 30 ).…”

Section: Resultsmentioning

confidence: 99%

Hepatotoxicity of Halogenated Inhalational Anesthetics

Safari¹,

Motavaf²,

Siamdoust³

et al. 2014

Iran Red Crescent Med J

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Context:Halogenated inhalational anesthetics are currently the most common drugs used for the induction and maintenance of general anesthesia. Postoperative hepatic injury has been reported after exposure to these agents. Based on much evidence, mechanism of liver toxicity is more likely to be immunoallergic. The objective of this review study was to assess available studies on hepatotoxicity of these anesthetics.Evidence Acquisition:We searched PubMed, Google Scholar, Scopus, Index Copernicus, EBSCO and the Cochrane Database using the following keywords: “inhalational Anesthetics” and “liver injury”; “inhalational anesthetics” and “hepatotoxicity”; “volatile anesthetics” and “liver injury”; “volatile anesthetics” and hepatotoxicity for the period of 1966 to 2013. Fifty two studies were included in this work.Results:All halogenated inhalational anesthetics are associated with liver injury. Halothane, enflurane, isoflurane and desflurane are metabolized through the metabolic pathway involving cytochrome P-450 2E1 (CYP2E1) and produce trifluoroacetylated components; some of which may be immunogenic. The severity of hepatotoxicity is associated with the degree by which they undergo hepatic metabolism by this cytochrome. However, liver toxicity is highly unlikely from sevoflurane as is not metabolized to trifluoroacetyl compounds.Conclusions:Hepatotoxicity of halogenated inhalational anesthetics has been well documented in available literature. Halothane-induced liver injury was extensively acknowledged; however, the next generation halogenated anesthetics have different molecular structures and associated with less hepatotoxicity. Although anesthesia-induced hepatitis is not a common occurrence, we must consider the association between this disorder and the use of halogenated anesthetics.

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Section: Resultsmentioning

confidence: 99%

Hepatotoxicity of Halogenated Inhalational Anesthetics

Safari¹,

Motavaf²,

Siamdoust³

et al. 2014

Iran Red Crescent Med J

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“…Furthermore, pain control in surgical and trauma patients is a major issue. In these patients, a valid chest wall expansion, effective coughing, mobilization, and positioning are the conditions for a rapid weaning from mechanical ventilation, and they are all dependent on adequate analgesia [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the past 20 years, in accordance with the growing interest and widespread diffusion of LRA in the critical patient, selected reviews have explored the topic [ 6 , 36 ].…”

Section: Introductionmentioning

confidence: 99%