Regional administration of natural killer cells in a rat hepatic metastasis model results in better tumor infiltration and anti-tumor response than systemic administration

Hagenaars, Martin; Ensink, N. G.; Koelemij, R.; Basse, Per H.; Eggermont, Alexander M.M.; Velde, Cornelis J.H. van de; Fleuren, Gert Jan; Kuppen, Peter J. K.

doi:10.1002/(sici)1097-0215(19980119)75:2<233::aid-ijc11>3.0.co;2-e

Cited by 25 publications

(30 citation statements)

References 18 publications

(29 reference statements)

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“…From day 12 on, human NK cells were recovered from blood and lymph nodes. This confirms the finding of Hagenaars et al (1998a), that human NK cells can migrate from the i.p. cavity into blood vessels.…”

Section: Viability and Localization Of Human Nk Cells After Ip Injesupporting

confidence: 92%

Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors

et al. 2000

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Section: Viability and Localization Of Human Nk Cells After Ip Injesupporting

confidence: 92%

Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors

et al. 2000

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“…injection than after i.v. injection of A-NK cells have recently been demonstrated by Hagenaars et al in a rat model [12].…”

Section: Discussionmentioning

confidence: 88%

Biodistribution and tumor localization of lymphokine-activated killer T cells following different routes of administration into tumor-bearing animals

Kjærgaard

Hokland²,

Agger³

et al. 2000

Cancer Immunol Immunother

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“…Previous experiments in our syngeneic rat CC531 liver tumor model demonstrated that IL-2 treatment consistently resulted in signi®cant antitumor responses [10] and was accompanied by an increase in the number of tumor-in®ltrating and tumor-surrounding NK cells and T cells [9]. The adoptive transfer of IL-2-cultured NK cells ± called A-NK cells ± could further enhance this antitumor eect [10].…”

Section: Discussionmentioning

confidence: 88%

Endogenous natural killer cells do not play a role in antitumor effects induced by interleukin-2 in a syngeneic rat colon tumor model

Hagenaars

Ensink

Eggermont

et al. 2000

Cancer Immunol Immunother

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Previous experiments in a syngeneic rat liver tumor model using the colon adenocarcinoma CC531 demonstrated that injection of interleukin-2 (IL-2) induced significant antitumor responses. Furthermore, it was found that this treatment strategy was accompanied by an increase in the number of natural killer (NK) cells in and around the tumor. In the present study, the role of endogenous NK cells in IL-2-mediated antitumor responses was further elucidated by depleting tumor-bearing rats of NK cells, using the anti-CD161A mouse IgG1 antibody 3.2.3. Rats were depleted either after or prior to tumor induction and subsequently treated with IL-2. The results demonstrated that depletion of NK cells in tumor-bearing rats did not influence IL-2-induced antitumor effects. In addition, injection of IL-2 in NK-cell-depleted rats induced repopulation of NK cells in the peripheral blood from 3 days on and further after the last injection with IL-2. Therefore, the possibility cannot be excluded that de novo recruited NK cells play a role in attaining IL-2 mediated antitumor effects, but NK cells, which were present before or during the start of IL-2 therapy, were not relevant.

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Regional administration of natural killer cells in a rat hepatic metastasis model results in better tumor infiltration and anti-tumor response than systemic administration

Cited by 25 publications

References 18 publications

Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors

Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors

Biodistribution and tumor localization of lymphokine-activated killer T cells following different routes of administration into tumor-bearing animals

Endogenous natural killer cells do not play a role in antitumor effects induced by interleukin-2 in a syngeneic rat colon tumor model

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