Regional acetylcholine turnover rates in the brains of three inbred strains of mice: Correlation with some interstrain behavioural differences

Durkin, T.; Ayad, G.; Ebel, A.; Mandel, P.

doi:10.1016/0006-8993(77)90072-5

Cited by 47 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, a significant amount of individual variation in ChAT‐ir fibers was present within our sample. Interindividual variation in cortical cholinergic innervation in the hippocampus, caudate nucleus, and frontoparietal cortex was positively correlated with performance on learning tasks in mice (Durkin et al,1975), and it has been suggested that variations in cholinergic innervation in human and nonhuman primates would reflect individual differences in learning abilities (Mesulam et al,1986).…”

Section: Discussionmentioning

confidence: 99%

Cholinergic innervation of the frontal cortex: Differences among humans, chimpanzees, and macaque monkeys

Raghanti

Stimpson

Marcinkiewicz

et al. 2007

J of Comparative Neurology

View full text Add to dashboard Cite

Cholinergic innervation of the frontal cortex is important in higher cognitive functions and may have been altered in humans relative to other species to support human-specific intellectual capacities. To evaluate this hypothesis we conducted quantitative comparative analyses of choline acetyltransferase-immunoreactive axons in cortical areas 9, 32, and 4 among humans, chimpanzees, and macaque monkeys. Area 9 of the dorsolateral prefrontal cortex is involved in inductive reasoning and specific components of working memory processes, while area 32 of the medial prefrontal cortex has been implicated in theory of mind. Area 4 (primary motor cortex) was also evaluated because it is not directly associated with higher cognitive functions. The findings revealed no quantitative species differences in the three cortical areas examined, indicating that human cognitive specializations are not related to a quantitative increase in cortical cholinergic input. However, species-specific morphological specializations were observed. Clusters of cholinergic fibers that may be indicative of cortical plasticity events were present in chimpanzees and humans, but not in macaques. The other significant morphology noted was the common and distinctive oval or ovoid perisomatic staining in macaque cortices. This feature was also sporadically observed in chimpanzee cortex. Our findings suggest a potential alteration of cortical cholinergic afferents within the prefrontal cortex of humans and chimpanzees, to the exclusion of macaque monkeys.

show abstract

Section: Discussionmentioning

confidence: 99%

Cholinergic innervation of the frontal cortex: Differences among humans, chimpanzees, and macaque monkeys

Raghanti

Stimpson

Marcinkiewicz

et al. 2007

J of Comparative Neurology

View full text Add to dashboard Cite

show abstract

“…The gene coding for the a 2 subunit is in a region on proximal chromosome 14 with markers associated with a cluster of METH-related phenotypes (discussed below). There is also substantial biochemical and histochemical evidence suggesting that B6 and D2 mice differ with respect to cholinergic activity (Ebel et al, 1973;Durkin et al, 1977) and cell density (Albanese et al, 1985;Iacopino et al, 1986;Schwab et al, 1990). Furthermore, the genetic variability in cholinergic cell number in the striatum was shown by Dains (1995) to be correlated with neuroleptic-induced catalepsy in the mouse, suggesting an interaction between acetylcholine and dopamine in the production of striatally mediated motor behavior.…”

Section: Candidate Neurotransmitter Modulationmentioning

confidence: 99%

Quantitative Trait Loci Affecting Methamphetamine Responses in BXD Recombinant Inbred Mouse Strains

et al. 1997

View full text Add to dashboard Cite

Individual differences in most behavioral and pharmacological responses to abused drugs are dependent on both genetic and environmental factors. The genetic influences on the complex phenotypes related to drug abuse have been difficult to study using classical genetic analyses. Quantitative trait locus (QTL) mapping is a method that has been used successfully to examine genetic contributions to some of these traits by correlating allelic variation in polymorphic genetic markers of known chromosomal location with variation in drug-response phenotypes. We evaluated several behavioral responses to multiple doses of methamphetamine (METH) in C57BL/6J (B6), DBA/2J (D2), and 25 of their recombinant inbred (BXD RI) strains. Stereotyped chewing, horizontal home cage activity, and changes in body temperature after 0, 4, 8, or 16 mg/kg METH, as well as stereotyped climbing behavior after 16 mg/kg METH, were examined. Associations (p < 0.01) between METH sensitivity and allelic status at multiple microsatellite genetic markers were subsequently determined for each response. QTLs were provisionally identified for each phenotype, some unique to a particular behavior and others that appeared to influence multiple phenotypes. Candidate genes suggested by these analyses included several that mapped near genes relevant for the neurotransmitters acetylcholine and glutamate. The locations of QTLs provisionally identified by this analysis were compared with QTLs hypothesized in other studies to influence methamphetamine- and cocaine-related phenotypes. In several instances, QTLs appeared to overlap, which is consistent with idea that common neural substrates underlie some responses to psychostimulants.

show abstract

“…Inbred strains of mice differing in spontaneous activity and reactivity to novelty have been reported to display regional differences in GABAergic and cholinergic activity and their regulation by opiate neurotransmitters (A1-Ani et aL, 1970;Durkin et al, 1977;Van Daal et aL, 1987). Moreover, differences in open-field activity and sensitivity to convulsant actions across mouse strains have been related to the density of GABAA/benzodiazepine receptors (Robertson, 1979;Chapouthier et al, 1991).…”

Section: Convulsant Effects Of ~-Ccmmentioning

confidence: 99%

Genetic analysis of anxiety-related behaviors and responses to benzodiazepine-related drugs in AXB and BXA recombinant inbred mouse strains

et al. 1995

View full text Add to dashboard Cite

Recombinant inbred (RI) strains derived from the C57BL/6J and A/J mouse strains were used for behavioral studies designed to estimate the number and location of chromosomal loci responsible for anxiety-related behaviors and differential sensitivity to agonists and inverse agonists of the gamma-aminobutyric acidA (GABAA)/benzodiazepine receptor complex. The phenotypes of the parental inbred strains and of 28 RI strains were characterized for the number of transitions in the light<-->dark exploratory model, anxiolytic response to diazepam, vertical and ambulatory activities in an open field, and sensitivity to the convulsant properties of methyl-beta-carboline-3-carboxylate (beta-CCM). The strain distribution patterns and estimates of the minimal number of loci obtained for each trait suggest that multiple chromosomal loci contribute to differences in anxiety-related behavioral phenotypes and the behavioral responses to diazepam and beta-CCM between C57BL/6J and A/J mice. The best probabilities of linkage were found between the variables characterizing response to diazepam and loci on chromosomes 1 (Xmv-41) and 10 (D10Mit2) and between the sensitivity to the convulsant actions of beta-CCM and locus D15Mit5 on chromosome 15.

show abstract

Regional acetylcholine turnover rates in the brains of three inbred strains of mice: Correlation with some interstrain behavioural differences

Cited by 47 publications

References 30 publications

Cholinergic innervation of the frontal cortex: Differences among humans, chimpanzees, and macaque monkeys

Cholinergic innervation of the frontal cortex: Differences among humans, chimpanzees, and macaque monkeys

Quantitative Trait Loci Affecting Methamphetamine Responses in BXD Recombinant Inbred Mouse Strains

Genetic analysis of anxiety-related behaviors and responses to benzodiazepine-related drugs in AXB and BXA recombinant inbred mouse strains

Contact Info

Product

Resources

About