“…This phenotype is associated with mutations in melanin production or melanosome biogenesis and turnover, and leads to decussation defects and mistargeting (Rice et al, 1995, Herrera et al, 2003, Rebsam et al, 2012, Bhansali et al, 2014, Jeffery, 2001). Birthdating experiments have suggested that this is due to a delay in the generation of RGCs in albino compared with pigmented retina (Bhansali et al, 2014, Drager, 1985, Gimenez et al, 2005, Lavado et al, 2006, Rachel et al, 2002). Given our results suggesting that a number of peripheral RGCs, including 22% of iRGCs, are generated in the CMZ and that their generation depends on Cyclin D2, we asked whether Cyclin D2 expression is compromised in the albino and therefore linked to the reduction of iRGCs.…”