Region Specific Vulnerability to Lipid Peroxidation in the Human Central Nervous System

Naudí, Alba; Jové, Mariona; Ayala, Victòria; Ramírez, Omar López; Cabré, Rosanna; Prat, Joan; Portero‐Otín, Manuel; Ferrer, Isidre; Pamplona, Reinald

doi:10.5772/46022

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…At temperatures above 100 °C, however, oxygen can attack the β-carbon of SFA and MUFA, to produce hydroperoxides as the primary peroxidation product. Similar to that for PUFA, SFA and MUFA have increased susceptibility to peroxidation with increasing carbon chain length [ 109 ]. In addition, the degree of unsaturation of a FA on the sn-1, sn-2, or sn-3 positions may also affect the susceptibility of a lipid to peroxidation.…”

Section: Lipid Peroxidationmentioning

confidence: 99%

Characteristics of lipids and their feeding value in swine diets

Kerr

Kellner

Shurson

2015

J Animal Sci Biotechnol

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In livestock diets, energy is one of the most expensive nutritional components of feed formulation. Because lipids are a concentrated energy source, inclusion of lipids are known to affect growth rate and feed efficiency, but are also known to affect diet palatability, feed dustiness, and pellet quality. In reviewing the literature, the majority of research studies conducted on the subject of lipids have focused mainly on the effects of feeding presumably high quality lipids on growth performance, digestion, and metabolism in young animals. There is, however, the wide array of composition and quality differences among lipid sources available to the animal industry making it essential to understand differences in lipid composition and quality factors affecting their digestion and metabolism more fully. In addition there is often confusion in lipid nomenclature, measuring lipid content and composition, and evaluating quality factors necessary to understand the true feeding value to animals. Lastly, advances in understanding lipid digestion, post-absorption metabolism, and physiological processes (e.g., cell division and differentiation, immune function and inflammation); and in metabolic oxidative stress in the animal and lipid peroxidation, necessitates a more compressive assessment of factors affecting the value of lipid supplementation to livestock diets. The following review provides insight into lipid classification, digestion and absorption, lipid peroxidation indices, lipid quality and nutritional value, and antioxidants in growing pigs.

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Section: Lipid Peroxidationmentioning

confidence: 99%

Characteristics of lipids and their feeding value in swine diets

Kerr

Kellner

Shurson

2015

J Animal Sci Biotechnol

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“…The brain is composed of 35% to 65% lipid on a DM basis, with myelin composition being approximately 80% lipid (O'Brien and Sampson, 1965) with differential degrees of unsaturation depending upon the phospholipid measured (Martinez and Mougan, 1998). Because of its high lipid content and high oxygen consumption, the brain is highly susceptible to oxidative damage (Naudi et al, 2012), with many neurodegenerative diseases related to varying degrees of oxidative stress in the brain (Adibhatla and Hatcher, 2010). Because biogenic amines are implicated in a wide range of body functions and behavior (Neuroscience, 2004), we elected to determine if pigs fed the SO processed at 90 °C, pigs that exhibited reduced ADG and G:F (Lindblom et al, 2018), would have had altered brain catecholamine concentrations and that this is a contributing factor to how dietary perioxidized lipids antagonize health and performance of growing pigs.…”

Section: Lipid Peroxidation and Brain Catecholaminesmentioning

confidence: 99%

Influence of feeding thermally peroxidized soybean oil on oxidative status in growing pigs

Lindblom

Gabler

Dilger

et al. 2018

Journal of Animal Science

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The objectives of this study were to determine whether feeding thermally processed peroxidized soybean oil (SO) induces markers of oxidative stress and alters antioxidant status in pig tissue, blood, and urine. Fifty-six barrows (25.3 ± 3.3 kg initial BW) were randomly assigned to dietary treatments containing 10% fresh SO (22.5 °C) or thermally processed SO (45 °C for 288 h, 90 °C for 72 h, or 180 °C for 6 h), each with constant air infusion rate of 15 liters/minute. Multiple indices of lipid peroxidation were measured in the SO including peroxide value (2.0, 96, 145, and 4.0 mEq/kg for 22.5, 45, 90, and 180 °C processed SO, respectively) and p-anisidine value (1.2, 8.4, 261, and 174 for 22.5, 45, 90, and 180 °C processed SO, respectively); along with a multitude of aldehydes. Pigs were individually housed and fed ad libitum for 49 d which included a 5 d period in metabolism crates for the collection of urine and serum for measures of oxidative stress. On day 49, pigs were euthanized to determine liver weight and analyze liver-based oxidative stress markers. Oxidative stress markers included serum, urinary, and liver thiobarbituric acid reactive substances (TBARS), and urinary F2-isoprostanes (ISP) as markers of lipid damage; serum and liver protein carbonyls (PC) as a marker of protein damage; and urinary and liver 8-hydroxy-2'-deoxyguanosine (8-OH-2dG) as a marker of DNA damage. Superoxide dismutase (SOD), and catalase activity (CAT) were measured in liver, glutathione peroxidase activity (GPx) was measured in serum and liver, and ferric reducing antioxidant power (FRAP) was measured in serum and urine as determinants of antioxidant status. Pigs fed 90 °C SO had greater urinary ISP (P = 0.02), while pigs fed the 45 °C SO had elevated urinary TBARS (P = 0.02) in comparison to other treatment groups. Pigs fed 45 °C and 90 °C SO had increased serum PC concentrations (P = 0.01) and pigs fed 90 °C SO had greater (P = 0.01) liver concentration of 8-OH-2dG compared to pigs fed the other SO treatments. Furthermore, pigs fed 90 °C SO had reduced serum GPx activity in comparison to pigs fed fresh SO (P = 0.01). In addition, pigs fed 180 °C SO had increased liver CAT activity (P = 0.01). Liver GPx and SOD or serum and urinary FRAP were not affected by dietary treatment. These results indicate that dietary peroxidized soybean oil induced oxidative stress by increasing serum PC while diminishing serum GPx, increasing urinary ISP and TBARS, and increasing 8-OH-2dG and CAT in liver.

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Peroxiredoxin V (PrdxV) negatively regulates EGFR/Stat3-mediated fibrogenesis via a Cys48-dependent interaction between PrdxV and Stat3

Choi

Kim

et al. 2019

Sci Rep

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Activation of the epidermal growth factor receptor (EGFR)/signal transducer and activator of transcription 3 (Stat3) signaling pathway has been reported to be associated with renal fibrosis. We have recently demonstrated that peroxiredoxin V (PrdxV) acted as an antifibrotic effector by inhibiting the activity of Stat3 in TGF-β-treated NRK49F cells. However, the underlying mechanism of PrdxV remains poorly understood. To investigate molecular mechanism of PrdxV, we used a transgenic mouse model expressing PrdxV siRNA (PrdxV si mice) and performed unilateral ureteral obstruction (UUO) for 7 days. 209/MDCT cells were transiently transfected with HA-tagged WT PrdxV and C48S PrdxV. Transgenic PrdxV si mice displayed an exacerbated epithelial-to-mesenchymal transition (EMT) as well as an increase in oxidative stress induced by UUO. In the UUO kidney of the PrdxV si mouse, knockdown of PrdxV increased Tyr1068-specific EGFR and Stat3 phosphorylation, whereas overexpression of WT PrdxV in 209/MDCT cells showed the opposite results. Immunoprecipitation revealed the specific interaction between WT PrdxV and Stat3 in the absence or presence of TGF-β stimulation, whereas no PrdxV-EGFR or C48S PrdxV-Stat3 interactions were detected under any conditions. In conclusion, PrdxV is an antifibrotic effector that sustains renal physiology. Direct interaction between PrdxV and Stat3 through Cys48 is a major molecular mechanism.

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Region Specific Vulnerability to Lipid Peroxidation in the Human Central Nervous System

Cited by 4 publications

References 36 publications

Characteristics of lipids and their feeding value in swine diets

Characteristics of lipids and their feeding value in swine diets

Influence of feeding thermally peroxidized soybean oil on oxidative status in growing pigs

Peroxiredoxin V (PrdxV) negatively regulates EGFR/Stat3-mediated fibrogenesis via a Cys48-dependent interaction between PrdxV and Stat3

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