Region-specific modulation of PER2 expression in the limbic forebrain and hypothalamus by nighttime restricted feeding in rats

Verwey, Michael; Khoja, Zehra; Stewart, Jane; Amir, Shimon

doi:10.1016/j.neulet.2008.05.043

Cited by 31 publications

(45 citation statements)

References 28 publications

(32 reference statements)

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“…This dissociation in the effect of DA on these regions is unusual because the daily patterns of PER2 expression in these regions are synchronized (Amir et al 2004;Lamont et al 2005), and we have previously shown that a number of stimuli that entrain rhythms of clock gene and protein expression, including restricted feeding (Waddington Lamont et al 2007;Verwey et al 2008) and changes in circulating levels of corticosterone , have a consistent effect on the patterns of PER2 in these two regions. The BNSTov and CEA share many anatomical, cellular, and functional characteristics and have been described as components of a larger limbic structure, referred to as the central extended amygdala (Alheid and Heimer 1988).…”

Section: -Ohda Injections Blunt Daily Per2 Patterns In Regions Of Thmentioning

confidence: 84%

Global Depletion of Dopamine Using Intracerebroventricular 6-Hydroxydopamine Injection Disrupts Normal Circadian Wheel-Running Patterns and PERIOD2 Expression in the Rat Forebrain

et al. 2011

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Normal circadian rhythms of behavior are disrupted in disorders involving the dopamine (DA) system, such as Parkinson's disease. We have reported previously using unilateral injections of the catecholamine toxin, 6-hydroxydopamine (6-OHDA), into the medial forebrain bundle that DA signaling regulates daily expression of the clock protein, PERIOD2 (PER2), in the dorsal striatum of the rat. In the present study, we made widespread lesions of DA fibers using large injections of 6-OHDA into the third ventricle to determine the involvement of DA in normal daily rhythms of wheel-running activity and PER2 patterns in the suprachiasmatic nucleus (SCN) and several regions of the limbic forebrain. Rats injected with 6-OHDA and housed in constant darkness were less active in the wheel and showed a disorganized pattern of activity in which wheel running was not confined to a specific phase over 24 h. The 6-OHDA injection had no effect on the daily PER2 pattern in the SCN, but blunted the normal rise in PER2 in the dorsal striatum. 6-OHDA also blunted PER2 expression in the periventricular nucleus of the hypothalamus, a region in which a daily PER2 pattern has not been previously reported in male rats, and in the oval nucleus of the bed nucleus of the stria terminalis, but not in the central nucleus of the amygdala. These results indicate that DA plays a prominent role in regulating circadian activity at both behavioral and molecular levels.

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Section: -Ohda Injections Blunt Daily Per2 Patterns In Regions Of Thmentioning

confidence: 84%

Global Depletion of Dopamine Using Intracerebroventricular 6-Hydroxydopamine Injection Disrupts Normal Circadian Wheel-Running Patterns and PERIOD2 Expression in the Rat Forebrain

et al. 2011

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“…Even so, the daily patterns of circadian clock gene expression are responsive to restricted feeding schedules, and this response is also region specific 57 . For example, restricted feeding schedules that provide daytime or nighttime meals will adjust circadian oscillations in some overlapping brain areas, but some of these effects will also depend on the meal time rather than the restriction, per se 42, 43 . The importance of the circadian time when food is consumed is further emphasized when rodents are fed a high-fat diet during either their active or their inactive period 64 .…”

Section: Sites and Sources Of Circadian Controlmentioning

confidence: 99%

Circadian influences on dopamine circuits of the brain: regulation of striatal rhythms of clock gene expression and implications for psychopathology and disease

Verwey¹,

Dhir

Amir³

2016

F1000Res

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Circadian clock proteins form an autoregulatory feedback loop that is central to the endogenous generation and transmission of daily rhythms in behavior and physiology. Increasingly, circadian rhythms in clock gene expression are being reported in diverse tissues and brain regions that lie outside of the suprachiasmatic nucleus (SCN), the master circadian clock in mammals. For many of these extra-SCN rhythms, however, the region-specific implications are still emerging. In order to gain important insights into the potential behavioral, physiological, and psychological relevance of these daily oscillations, researchers have begun to focus on describing the neurochemical, hormonal, metabolic, and epigenetic contributions to the regulation of these rhythms. This review will highlight important sites and sources of circadian control within dopaminergic and striatal circuitries of the brain and will discuss potential implications for psychopathology and disease . For example, rhythms in clock gene expression in the dorsal striatum are sensitive to changes in dopamine release, which has potential implications for Parkinson’s disease and drug addiction. Rhythms in the ventral striatum and limbic forebrain are sensitive to psychological and physical stressors, which may have implications for major depressive disorder. Collectively, a rich circadian tapestry has emerged that forces us to expand traditional views and to reconsider the psychopathological, behavioral, and physiological importance of these region-specific rhythms in brain areas that are not immediately linked with the regulation of circadian rhythms.

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“…These include the DMH (Gooley et al 2006;Mieda et al 2006;Verwey et al 2007Verwey et al , 2008, dorsal striatum and nucleus accumbens (Angeles-Castellanos et al 2007;Verwey and Amir 2011), the cerebral cortex and hippocampus (Wakamatsu et al 2001), the stomach (LeSauter et al 2009), and the liver (Stokkan et al 2001). …”

Section: Oscillators Mediating Anticipation Of Feedingmentioning

confidence: 99%

Circadian Insights into Motivated Behavior

Antle

Silver

2015

Current Topics in Behavioral Neurosciences

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For an organism to be successful in an evolutionary sense, it and its offspring must survive. Such survival depends on satisfying a number of needs that are driven by motivated behaviors, such as eating, sleeping, and mating. An individual can usually only pursue one motivated behavior at a time. The circadian system provides temporal structure to the organism's 24 hour day, partitioning specific behaviors to particular times of the day. The circadian system also allows anticipation of opportunities to engage in motivated behaviors that occur at predictable times of the day. Such anticipation enhances fitness by ensuring that the organism is physiologically ready to make use of a time-limited resource as soon as it becomes available. This could include activation of the sympathetic nervous system to transition from sleep to wake, or to engage in mating, or to activate of the parasympathetic nervous system to facilitate transitions to sleep, or to prepare the body to digest a meal. In addition to enabling temporal partitioning of motivated behaviors, the circadian system may also regulate the amplitude of the drive state motivating the behavior. For example, the circadian clock modulates not only when it is time to eat, but also how hungry we are. In this chapter we explore the physiology of our circadian clock and its involvement in a number of motivated behaviors such as sleeping, eating, exercise, sexual behavior, and maternal behavior. We also examine ways in which dysfunction of circadian timing can contribute to disease states, particularly in psychiatric conditions that include adherent motivational states.

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Region-specific modulation of PER2 expression in the limbic forebrain and hypothalamus by nighttime restricted feeding in rats

Cited by 31 publications

References 28 publications

Global Depletion of Dopamine Using Intracerebroventricular 6-Hydroxydopamine Injection Disrupts Normal Circadian Wheel-Running Patterns and PERIOD2 Expression in the Rat Forebrain

Global Depletion of Dopamine Using Intracerebroventricular 6-Hydroxydopamine Injection Disrupts Normal Circadian Wheel-Running Patterns and PERIOD2 Expression in the Rat Forebrain

Circadian influences on dopamine circuits of the brain: regulation of striatal rhythms of clock gene expression and implications for psychopathology and disease

Circadian Insights into Motivated Behavior

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