Region-specific maturation of cerebral cortex in human fetal brain: diffusion tensor imaging and histology

Trivedi, Richa; Gupta, Rakesh K.; Husain, Nuzhat; Rathore, Ram K.S.; Saksena, Sona; Srivastava, Savita; Malik, G. K.; Das, Vinita; Pradhan, Mandakini; Sarma, Manoj K.; Pandey, Chandra M.; Narayana, Ponnada A.

doi:10.1007/s00234-009-0533-8

Cited by 46 publications

(36 citation statements)

References 40 publications

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“…Given fetal diffusion values and maturation curves obtained between 22 and 36 weeks, our findings of ADC and FA values were comparable with the ones presented by different groups, [20][21][22] though subtle differences between fetuses at 37 weeks of gestation and preterm infants at TEA were reported. 23 No fetal data of T1 values are available.…”

Section: Discussionsupporting

confidence: 89%

Evolution of T1 Relaxation, ADC, and Fractional Anisotropy during Early Brain Maturation: A Serial Imaging Study on Preterm Infants

Schneider¹,

Kober

Graz³

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:The alteration of brain maturation in preterm infants contributes to neurodevelopmental disabilities during childhood. Serial imaging allows understanding of the mechanisms leading to dysmaturation in the preterm brain. The purpose of the present study was to provide reference quantitative MR imaging measures across time in preterm infants, by using ADC, fractional anisotropy, and T1 maps obtained by using the magnetization-prepared dual rapid acquisition of gradient echo technique.

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Section: Discussionsupporting

confidence: 89%

Evolution of T1 Relaxation, ADC, and Fractional Anisotropy during Early Brain Maturation: A Serial Imaging Study on Preterm Infants

Schneider¹,

Kober

Graz³

et al. 2015

AJNR Am J Neuroradiol

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“…Direct diffusion-neuroanatomic correlations are difficult to acquire in human infants, and the data are few and only partially relevant (27). Fortunately, precise information is available from experimental studies.…”

Section: Discussionmentioning

confidence: 99%

Development of cortical microstructure in the preterm human brain

Ball

Srinivasan

Aljabar

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

308

289

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Cortical maturation was studied in 65 infants between 27 and 46 wk postconception using structural and diffusion magnetic resonance imaging. Alterations in neural structure and complexity were inferred from changes in mean diffusivity and fractional anisotropy, analyzed by sampling regions of interest and also by a unique whole-cortex mapping approach. Mean diffusivity was higher in gyri than sulci and in frontal compared with occipital lobes, decreasing consistently throughout the study period. Fractional anisotropy declined until 38 wk, with initial values and rates of change higher in gyri, frontal and temporal poles, and parietal cortex; and lower in sulcal, perirolandic, and medial occipital cortex. Neuroanatomical studies and experimental diffusion-anatomic correlations strongly suggested the interpretation that cellular and synaptic complexity and density increased steadily throughout the period, whereas elongation and branching of dendrites orthogonal to cortical columns was later and faster in higher-order association cortex, proceeding rapidly before becoming undetectable after 38 wk. The rate of microstructural maturation correlated locally with cortical growth, and predicted higher neurodevelopmental test scores at 2 y of age. Cortical microstructural development was reduced in a dose-dependent fashion by longer premature exposure to the extrauterine environment, and preterm infants at term-corrected age possessed less mature cortex than term-born infants. The results are compatible with predictions of the tension theory of cortical growth and show that rapidly developing cortical microstructure is vulnerable to the effects of premature birth, suggesting a mechanism for the adverse effects of preterm delivery on cognitive function. brain development | DTI | preterm birth D endritic arborization and synapse formation increase within the cerebral cortical plate from midgestation, transforming the cortex from a predominantly radial formation arrayed perpendicular to the cortical surface into a denser, more complex structure with large numbers of neural connections running parallel to the surface (1). Several groups have related this microstructural maturation to changes in the rate and principal direction of water diffusion within the cortex observed in vivo by diffusion tensor imaging (DTI) (2-5). It is proposed that increasing cellular density and complexity lead to a decrease in tissue water content and a fall in mean diffusivity (MD) (6-9), whereas decreases in the relative fraction of water diffusion perpendicular to the cortical surface, measured as a decline in fractional anisotropy (FA), reflect neurite outgrowth and maturing dendritic cytoarchitecture (7,8,(10)(11)(12). These changes have been measured in neonatal piglets (13), cats (14), and mice (15), and in pioneering studies of preterm infants (3,4,8).The present study used structural MRI and DTI to examine the spatial and temporal development of human cortical microstructure. We reasoned that if the process was impaired by preterm birth we...

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“…Despite the successes of DTI, it remains challenging to attribute changes in parameters to specific microstructural changes (Trivedi et al, 2009). Bulk measures such as FA conflate several effects: a low FA measurement could be due to partial volume effects with CSF, fibre dispersion, the cellular density changing or a change in myelination state.…”

Section: Introductionmentioning

confidence: 98%

Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal MRI

Eaton-Rosen¹,

Melbourne²,

Orasanu³

et al. 2015

NeuroImage

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Preterm birth is a major public health concern, with the severity and occurrence of adverse outcome increasing with earlier delivery. Being born preterm disrupts a time of rapid brain development: in addition to volumetric growth, the cortex folds, myelination is occurring and there are changes on the cellular level. These neurological events have been imaged non-invasively using diffusion-weighted (DW) MRI. In this population, there has been a focus on examining diffusion in the white matter, but the grey matter is also critically important for neurological health. We acquired multi-shell high-resolution diffusion data on 12 infants born at ≤ 28 weeks of gestational age at two time-points: once when stable after birth, and again at term-equivalent age. We used the Neurite Orientation Dispersion and Density Imaging model (NODDI) (Zhang et al., 2012) to analyse the changes in the cerebral cortex and the thalamus, both grey matter regions. We showed region-dependent changes in NODDI parameters over the preterm period, highlighting underlying changes specific to the microstructure. This work is the first time that NODDI parameters have been evaluated in both the cortical and the thalamic grey matter as a function of age in preterm infants, offering a unique insight into neuro-development in this at-risk population.

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Region-specific maturation of cerebral cortex in human fetal brain: diffusion tensor imaging and histology

Abstract: The DTI-derived FA quantification with its GFAP immunohistologic correlation in cortical regions of the various lobes of the cerebral hemispheres supports region-specific migrational and maturational events in human fetal brain.

Cited by 46 publications

References 40 publications

Evolution of T1 Relaxation, ADC, and Fractional Anisotropy during Early Brain Maturation: A Serial Imaging Study on Preterm Infants

Evolution of T1 Relaxation, ADC, and Fractional Anisotropy during Early Brain Maturation: A Serial Imaging Study on Preterm Infants

Development of cortical microstructure in the preterm human brain

Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal MRI

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