2010
DOI: 10.1186/1423-0127-17-14
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Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy study

Abstract: BackgroundBoth hypoxia and hyperoxia, deregulating the oxidative balance, may play a role in the pathology of neurodegenerative disorders underlain by cerebral ischemia. In the present study, quantitative proton magnetic resonance spectroscopy was used to evaluate regional metabolic alterations, following a 24-hour hypoxic or hyperoxic exposure on the background of ischemic brain insult, in two contrasting age-groups of rats: young - 3 months old and aged - 24 months old.MethodsCerebral ischemia was induced by… Show more

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Cited by 37 publications
(23 citation statements)
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References 31 publications
(39 reference statements)
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“…From another perspective, the antidepressant phenelzine, a monoamine oxidase inhibitor, also elevates rat brain levels of alanine by inhibition of aminotransferase activity [65]. It is noteworthy that ischemia–hypoxia also caused decreased alanine levels in the rat brain [66], which is in a line with our observations.…”
Section: Discussionsupporting
confidence: 86%
“…From another perspective, the antidepressant phenelzine, a monoamine oxidase inhibitor, also elevates rat brain levels of alanine by inhibition of aminotransferase activity [65]. It is noteworthy that ischemia–hypoxia also caused decreased alanine levels in the rat brain [66], which is in a line with our observations.…”
Section: Discussionsupporting
confidence: 86%
“…In the present work, the cardiorespiratory reflexes induced by carotid ischemia were similar in young and old rats. Previous work has addressed the impairment of carotid ischemia on cerebral oxidative balance caused by permanent ligation of the right carotid artery (Macri et al 2010) in old animals. These are long-term ischemia and the authors did not address the effects of the ventilatory reflexes induced by carotid ischemia in aged animals, shown for the first time in the present work.…”
Section: Discussionmentioning
confidence: 99%
“…(13, 14) Hypoxia is associated with hippocampal neuronal death in animal models. (15, 16) Despite these possible central nervous system effects of asthma, few studies, to date, have used neuroimaging to examine brain structure or functioning in asthma patients and none have focused on the hippocampus. A small study using MRI in mild to moderate asthma found that 13 out of 21 (62%) participants had incidental brain MRI abnormalities (including deep white matter hyperintensities, perivascular space, and abnormal anatomic findings).…”
Section: Introductionmentioning
confidence: 99%