Region-dependent bone loss in the lumbar spine following femoral fracture in mice

Ely, Erica V.; Osipov, Benjamin; Emami, Armaun J.; Christiansen, Blaine A.

doi:10.1016/j.bone.2020.115555

Cited by 2 publications

(1 citation statement)

References 18 publications

(20 reference statements)

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“…Unfortunately, aged individuals experience a natural decline in healing potential, which leads to significant delays in bone healing that prolongs patient suffering (Nieminen et al, 1981 ; Nikolaou et al, 2009 ). Fracture healing is also delayed in aged mice (Clark et al, 2020 ; Clement et al, 2022 ; Liu et al, 2022 ; Naik et al, 2009 ) and these fractures induce exacerbated systemic responses compared to young mice, including increased inflammation (Emami et al, 2019 ), post‐traumatic bone loss (Ely et al, 2020 ; Emami et al, 2019 ), and pain (Majuta et al, 2018 ). Identifying novel strategies that can accelerate bone repair while simultaneously attenuating many of the fracture‐induced sequalae is of special interest to the elderly population.…”

Section: Introductionmentioning

confidence: 99%

Bifidobacterium longum supplementation improves age‐related delays in fracture repair

et al. 2023

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Age‐related delays in bone repair remains an important clinical issue that can prolong pain and suffering. It is now well established that inflammation increases with aging and that this exacerbated inflammatory response can influence skeletal regeneration. Recently, simple dietary supplementation with beneficial probiotic bacteria has been shown to influence fracture repair in young mice. However, the contribution of the gut microbiota to age‐related impairments in fracture healing remains unknown. Here, we sought to determine whether supplementation with a single beneficial probiotic species, Bifidobacterium longum (B. longum), would promote fracture repair in aged (18‐month‐old) female mice. We found that B. longum supplementation accelerated bony callus formation which improved mechanical properties of the fractured limb. We attribute these pro‐regenerative effects of B. longum to preservation of intestinal barrier, dampened systemic inflammation, and maintenance of the microbiota community structure. Moreover, B. longum attenuated many of the fracture‐induced systemic pathologies. Our study provides evidence that targeting the gut microbiota using simple dietary approaches can improve fracture healing outcomes and minimize systemic pathologies in the context of aging.

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