Regio- and Stereoselective Rhodium(II)-Catalyzed C–H Functionalization of Cyclobutanes

Abstract

In the original Supplemental Information for this article, the NMR data for compound 8 on page S23 unfortunately contained data from a different but related compound that was ultimately not included in the paper. Additionally, supporting NMR spectra for compound 8 were inadvertently omitted from the section ''Nuclear Magnetic Resonance Spectra.'' Therefore, the NMR data have been corrected on page S23,

Diaryldiazoketones as Effective Carbene Sources for Highly Selective Rh(II)-Catalyzed Intermolecular C–H Functionalization

“…The arylcyclobutane system is a good test for the steric encumbrance associated with the catalysts because sterically crowded catalyst preferentially reacts at the methylene site at C3. 12 The formation of the tertiary C−H functionalization product is a further indication that the Rh 2 (S-TPPTTL) 4 /aryl ketone carbene system is not particularly sterically demanding.…”

A Practical Route to Cyclobutanols and Fluorocyclobutanes

“…This well‐established approach is convergent and powerful, but it is limited by the incompatibility of the organometallic reagents with many polar entities and by the difficulty of implementing such methods for the late‐stage modification of advanced candidates in medicinal chemistry programs. References [18–21] give academic examples of additions of pyridine derived organolithiums and Grignard reagents to cyclobutanones; many more can be found in the patent literature, reflecting the importance of such compounds for the pharmaceutical industry. We herein describe a radical based strategy that complements conventional ionic and organometallic methods and allows access to structures not readily available by more established approaches.…”