Regio- and diastereoselective synthesis of N-substituted 2-acyl-3-aryl-3,5-dihydrofuro[3,2-c]pyridin-4(2H)-ones

Recent advances in the application of ylide-like species in [4 + 1]-annulation reactions: an updated review

“…Apart from quaternary ammonium ylides, pyridinium ylides react via [4 + 1]-annulation with 1,3-dicarbonylydene com-pounds, as demonstrated in a number of recent works (Scheme 42). [83][84][85][86][87][88][89][90] Pyridinium ylides 115 are often generated in situ from α-haloketones 61 and pyridine, while 1,3-dicarbonylydenes are formed by condensation of 1,3-dicarbonyl compounds 114 with aldehydes. The combination of these reactions in a one-pot process provides an expedient multi-component excess to annulated dihydrofurans 116.…”