Regenerative Treatment for Tympanic Membrane Perforation

Kanemaru, Shin‐ichi; Umeda, Hiroaki; Kitani, Yoshiharu; Nakamura, Tatsuo; Hirano, Shigeru; Ito, Juichi

doi:10.1097/mao.0b013e31822e0e53

Cited by 120 publications

(129 citation statements)

References 23 publications

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“…The addition of bFGF [5], a growth factor that stimulates neovascularisation and the proliferation of epidermal and connective tissue cells [6], should improve the rate of successful closure of perforated TMs and extend the treatment indications [7][8][9][10]. Lou et al reported that the direct application of FGF improved healing and shortened the closure time of acute traumatic perforations [5].…”

Section: Discussionmentioning

confidence: 96%

“…Lou et al reported that the direct application of FGF improved healing and shortened the closure time of acute traumatic perforations [5]. For chronic TM perforations, however, mechanical disruption of the edge of the perforation is required to stimulate the activity of TM stem cells [10], because the outer squamous epithelium of the TM grows medially around the edge of the perforation contacting the inner mucosal layer and acts as a limiting healing barrier on the middle connective tissue layer, preventing closure of the perforation [11]. In adults, the regenerative therapy with atelocollagen combined with bFGF can be performed under local anesthesia in less than 5 min without a skin incision.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Use of ambulatory anesthesia with manually assisted ventilation for tympanic membrane regeneration therapy in children

Hakuba

Ikemune

Okada

et al. 2015

American Journal of Otolaryngology

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Use of ambulatory anesthesia with manually assisted ventilation for tympanic membrane regeneration therapy in children

Hakuba

Ikemune

Okada

et al. 2015

American Journal of Otolaryngology

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“…Basic FGF also has strong angiogenic effects which lead to increased blood supply and growth factors to the target tissues. Kanemaru et al reported positive effects of implanted gelatin sponge combined with bFGF on regeneration of the tympanic membrane in patients with tympanic perforation [ 11 ]. A global clinical trial is currently under preparation to further test this in Japan and the United States.…”

Section: Exploratory Clinical Trials For Growth Factorsmentioning

confidence: 95%

Future Prospective

Hirano¹,

Kanemaru²

2015

Regenerative Medicine in Otolaryngology

Self Cite

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All human beings have the dream to one day completely regenerate damaged tissues and organs. The past three decades have seen the emergence and development of advanced tissue engineering and regenerative medicine and the great potential now exists to make this dream a reality. However, forecasting the future direction of tissue engineering and regenerative medicine is no simple matter. Within a span of less than 10 years, induced pluripotent stem cells (iPSCs) were established and the three-dimensional bioprinter (3D bioprinter) were developed. These innovations that seemed beyond the scope of our imagination have the potential to make remarkable progress and dramatic shifts in the medical fi eld.For simple tissues, such as skin and blood vessels, these innovations have achieved some marked success. However, there are major issues that limit the application of these strategies to complex tissues and organs. It is unreasonable to expect that simple implantation of organs created ex vivo into the living body will result in successful regeneration. Blood supply is an absolute requirement for engraftment into the host and innervation is also necessary for functional regeneration. The key to complete successful regeneration lies in the appropriate combination of cells, scaffolds, and regulatory factors, and critical to this is the creation of a favorable regenerative environment.The otolaryngology, head and neck fi eld, encompasses regions that consist of various organs and tissues that are critical for maintaining important functions such as mastication, articulation, phonation, respiration, and swallowing. These body systems also have several important neurosensory functions including hearing, balance, smell, and taste. Once these functions have deteriorated, quality of life (QOL) is greatly compromised. This fi eld represents one of the best opportunities where tissue engineering and regenerative medicine is expected to work as an innovative

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“…New surgical techniques, such as the use of b-FGF (fibroblast growth factor) on gelatin sponge held in position by fibrin glue, which can be highly successful at treating even large perforations, are also currently being investigated [49].…”

Section: Future Directionsmentioning

confidence: 99%