Regenerative potential of bone marrow mesenchymal stem cells on cadmium chloride-induced hepato-renal injury and testicular dysfunction in sprague dawley rats

Elbaghdady, Heba Allah M.; Alwaili, Maha Abdulla; EL-Demerdash, Reda S.

doi:10.1016/j.ecoenv.2018.07.019

Cited by 15 publications

(12 citation statements)

References 28 publications

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“…Apoptosis affects the synthesis of testosterone, which in turn affects the normal male reproductive function. The results are basically consistent with the findings of related studies (Elbaghdady et al, 2018).…”

Section: Discussionsupporting

confidence: 93%

Reproductive toxicity of cadmium in pubertal male rats induced by cell apoptosis

Dai

Chen

et al. 2021

Toxicol Ind Health

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Cadmium (Cd) is a heavy metal that is widely present in modern industrial production. It is a known, highly toxic environmental endocrine disruptor. Long-term exposure to Cd can cause varying degrees of damage to the liver, kidney, and reproductive system of organisms, especially the male reproductive system. This study aimed to explore the mechanism of Cd toxicity in the male reproductive system during puberty. Eighteen healthy 6-week-old male Sprague–Dawley rats were randomly divided into three groups (control group, low-dose group, and high-dose group) according to their body weight, with six in each group. Cd (0, 1, and 3 mg/kg/day) was given by gavage for 28 consecutive days. The results showed that Cd exposure to each dose group caused a decrease in the testicular organ coefficient and sperm count, compared with the control group. Cd exposure resulted in significant changes in testicular morphology in the 3 mg/kg/day Cd group. In the 1 and 3 mg/kg/day Cd groups, serum testosterone decreased and apoptosis of testicular cells increased significantly ( p < 0.05). In addition, compared with the control group, the activity of glutathione peroxidase and superoxide dismutase in each Cd exposure dose group decreased, but the content of malondialdehyde in the high-dose, 3 mg/kg/day Cd treatment group significantly increased ( p < 0.05). Although Cd exposure caused an increase in the messenger RNA (mRNA) levels of Bcl-2, Caspase-3 and Caspase-9 in the testicular tissues ( p < 0.05), Bcl-2 expression was unchanged ( p > 0.05). The expression level of Akt mRNA in testicular tissue of rats in the high-dose 3 mg/kg/day Cd group was increased ( p < 0.05). Our data suggest that Cd affected testosterone levels, and apoptosis was observed in spermatids.

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Section: Discussionsupporting

confidence: 93%

Reproductive toxicity of cadmium in pubertal male rats induced by cell apoptosis

Dai

Chen

et al. 2021

Toxicol Ind Health

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“…After the eligibility criteria were applied on the remaining 665 articles, five unduplicated studies were included in this review. A flow chart for the selection process is presented in figure1 Study characteristics: According to the publication date, the included five studies were divided into one performed in Saudi Arabia at 2015 [16] , one in china at 2017 [14] , two in Egypt at 2018 [12,13,15] . All studies used cadmium chloride to induce toxicity with different concentrations ranging from, 0.4-5 mg/kg body weight.…”

Section: Resultsmentioning

confidence: 99%

Impact of Bone Marrow Mesenchymal Stem Cells on Different Body Organs of Albino Rats Exposed To Cadmium Chloride Toxicity: A Systematic Review

2021

IJFMT

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Background and Objective: Cadmium chloride (Cd cl 2 ) is a highly toxic heavy metal that causes severe degenerative effects to different body organs. Bone marrow mesenchymal stem cells (BMMSCs) may have a protective effect upon CdCl 2 induced structural and functional changes in the rat's organs. This systematic review aimed to test the regenerative effects of bone marrow-derived mesenchymal stem cells on different body organs of albino rats exposed to cadmium chloride toxicity.Methods: Experimental animal studies were identified by the following electronic databases: PubMed, Scopus, Ovid Medline, KoreaMed, Google Scholar, Latin American and Caribbean Health Sciences Literature (LILACS) and Central Cochrane Library. The literature search was done from January 2010 to 2020. Conclusion:From the selected articles, using stem cell therapy enhances the regeneration process in CdCl 2 toxicity of different body organs.

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“…Semen analysis showed that sub chronic exposure to Cd and Cr resulted in a significant decrease in total sperm count and viability with a significant increase in the percent of sperms with abnormal morphology. Cadmium induced damage to the testicular germinal epithelium, the Leydig cells and the Sertoli cells resulting Mans Vet Med J 20:3 (2019) [14][15][16][17][18] in testicular and cellular damage which adversely affected sperm characters [7,26]. Exposure to Cd disrupted the tight junctions between Sertoli cells and altered germ cell adhesion with consequent exfoliation of immature cells into the lumen of seminiferous tubules, leading to a decrease in viable sperm count [37].…”

Section: Discussionmentioning

confidence: 99%

Effects of Cadmium and /or Chromium on reproductive organs and semen profiles of male albino rats

et al. 2019

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Objective: To evaluate the potential hazards of cadmium and/or chromium on the reproductive system of adult male albino rat. Design: Randomized controlled study. Animals: Forty mature male albino rats weighing 260 ± 10 g. Procedures: Rats were allocated into four groups (ten animals each). Control group (group 1), group 2 received 4.4 mg kg-1 cadmium chloride, group 3 was given 2.5 mg kg-1 sodium dichromate and group 4 received combination of Cd (2.2 mg kg-1) and Cr (1.25mg kg-1) orally, once daily for 65 consecutive days. Results: Exposure to Cd or Cr, in particular their combination, caused a reduction in the index weights of testes, epididymis, seminal vesicle and prostate glands. They induced a reduction of sperm count and viability with an increase of abnormal sperm morphology. Interestingly, in the combination group (Cd and Cr together), the deleterious effects were more noticeable. Pathologically, both Cd and Cr produced degenerative changes in seminiferous tubules, necrosis of spermatogenic epithelium within the testis. Moreover, the interstitial tissue of epididymis showed marked edema and prostate showed necrosis and serous exudate of lining epithelium. In the interaction group, testis showed complete degenerative changes and necrosis of spermatogenic epithelium, with marked interstitial edema and hyperplastic epithelial lining of epididymal tubules. Conclusion and clinical relevance: The present results support the hypothesis that the testis is one of the most sensitive organs to Cd and/or Cr and that the exposure to any of them or to their combination lead to testicular damage and thereby male infertility.

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Regenerative potential of bone marrow mesenchymal stem cells on cadmium chloride-induced hepato-renal injury and testicular dysfunction in sprague dawley rats

Cited by 15 publications

References 28 publications

Reproductive toxicity of cadmium in pubertal male rats induced by cell apoptosis

Reproductive toxicity of cadmium in pubertal male rats induced by cell apoptosis

Impact of Bone Marrow Mesenchymal Stem Cells on Different Body Organs of Albino Rats Exposed To Cadmium Chloride Toxicity: A Systematic Review

Effects of Cadmium and /or Chromium on reproductive organs and semen profiles of male albino rats

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