Regenerative Medicine of Epithelia: Lessons From the Past and Future Goals

Maurizi, Eleonora; Adamo, Davide; Magrelli, Federica Maria; Galaverni, Giulia; Attico, Eustachio; Merra, Alessia; Maffezzoni, Maria Benedetta Rizzarda; Losi, Lorena; Genna, Vincenzo Giuseppe; Sceberras, Virginia; Pellegrini, Graziella

doi:10.3389/fbioe.2021.652214

Cited by 17 publications

(13 citation statements)

References 188 publications

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“…Epithelial cells are present in various organs, including the epidermis, cornea, intestine, and respiratory tract, exerting unique functions in each tissue, thereby contributing to the maintenance of tissue homeostasis. 1) For instance, epidermal keratinocytes in differentiated states constitute four layers, the stratum basale, stratum spinosum, stratum granulosum, and stratum corneum, forming stratified squamous. 2,3) Proliferation and differentiation of epidermal keratinocytes should be appropriately regulated for normal epidermal barrier function, turnover, and wound repairing.…”

Section: Introductionmentioning

confidence: 99%

Polyunsaturated Fatty Acid-Derived Lipid Mediators That Regulate Epithelial Homeostasis

Naganuma

Fujinami

Arita

2022

Biological & Pharmaceutical Bulletin

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Epithelial tissues are mainly composed of epithelial cells, covering both internal and external surfaces of our body. To maintain epithelial homeostasis, cellular functions, such as proliferation, migration, and differentiation, are flexibly regulated in response to changes in the cellular status, thereby contributing to barrier formation, immune reaction, and wound closure. Polyunsaturated fatty acids (PUFAs) are precursors of various lipid mediators that maintain tissue homeostasis by exerting characteristic bioactivities. This review aimed to summarize the role of PUFA-derived lipid mediators in epithelial cell functions, mainly focusing on the epidermis, cornea, and intestinal epithelium. Key words polyunsaturated fatty acid; lipid mediator; epithelium 2. PUFA-DERIVED MEDIATORS THAT REGU-LATE EPITHELIAL HOMEOSTASIS 2.1. COX Metabolites COXs are rate-limiting enzymes in the production of prostanoids, such as prostaglandins and thromboxanes from AA. COX has two isozymes, COX1 and COX2. COX1 is referred to as a "constitutive isozyme" that

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Section: Introductionmentioning

confidence: 99%

Polyunsaturated Fatty Acid-Derived Lipid Mediators That Regulate Epithelial Homeostasis

Naganuma

Fujinami

Arita

2022

Biological & Pharmaceutical Bulletin

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“…On this note, in TE approaches, the culture conditions used for the in vitro expansion phase must preserve the proliferative and differentiative potential of the airway epithelial stem cells, preventing their exhaustion. Indeed, the experience gained from regenerative approaches of other human epithelial tissues clearly pointed out that a specific number of stem cells is strictly required to allow the permanent engraftment, renewal, and restoration of the epithelium ( Pellegrini et al, 2011 ; Maurizi et al, 2021 ). In order to carefully monitor these aspects and have a clear overview of all the process variables, extensive cellular characterization must be performed.…”

Section: Discussionmentioning

confidence: 99%

The Growing Medical Need for Tracheal Replacement: Reconstructive Strategies Should Overcome Their Limits

Adamo

Galaverni

Genna

et al. 2022

Front. Bioeng. Biotechnol.

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Breathing, being predominantly an automatic action, is often taken for granted. However, respiratory diseases affect millions of people globally, emerging as one of the major causes of disability and death overall. Among the respiratory dysfunctions, tracheal alterations have always represented a primary challenge for clinicians, biologists, and engineers. Indeed, in the case of wide structural alterations involving more than 50% of the tracheal length in adults or 30% in children, the available medical treatments are ineffective or inapplicable. So far, a plethora of reconstructive approaches have been proposed and clinically applied to face this growing, unmet medical need. Unfortunately, none of them has become a well-established and routinely applied clinical procedure to date. This review summarizes the main clinical reconstructive attempts and classifies them as non-tissue engineering and tissue engineering strategies. The analysis of the achievements and the main difficulties that still hinder this field, together with the evaluation of the forefront preclinical experiences in tracheal repair/replacement, is functional to promote a safer and more effective clinical translation in the near future.

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“…These explains the low rate (1.5%) of adverse reactions in our study, being classified as minor reactions. [ 34 35 36 ]…”

Section: Discussionmentioning

confidence: 99%

Use of cultivated epidermal allograft in chronic wounds: A novel therapeutic alternative

De-Luna-Gallardo

Cahuana-Quispe

García-Espinoza

et al. 2022

J Cutan Aesthet Surg

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Regenerative Medicine of Epithelia: Lessons From the Past and Future Goals

Cited by 17 publications

References 188 publications

Polyunsaturated Fatty Acid-Derived Lipid Mediators That Regulate Epithelial Homeostasis

Polyunsaturated Fatty Acid-Derived Lipid Mediators That Regulate Epithelial Homeostasis

The Growing Medical Need for Tracheal Replacement: Reconstructive Strategies Should Overcome Their Limits

Use of cultivated epidermal allograft in chronic wounds: A novel therapeutic alternative

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