Regenerative Medicine: Multiphasic Collagen Scaffolds for Engineered Tissue Interfaces (Adv. Funct. Mater. 48/2018)

Lausch, Alexander J.; Chong, Lester C.; Uludağ, Hasan; Sone, Eli D.

doi:10.1002/adfm.201870343

Cited by 1 publication

(4 citation statements)

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Section: Discussionmentioning

confidence: 99%

“…The degree of collagen mineralization can be controlled by the duration of immersion. [128] Through this proposal, a three-layer collagen scaffold could be achieved based on a highly mineralized collagen gel layer, combining an unmineralized middle layer and a thin mineralized top layer; the layers are interlinked (Figure 13). The integrated multilayer scaffold with different degrees of mineralization is designed to mimic the periodontal complex consisting of bone, periodontal ligament, and cementum.…”

Section: Acp Nanoparticlesmentioning

confidence: 99%

“…The integrated multilayer scaffold with different degrees of mineralization is designed to mimic the periodontal complex consisting of bone, periodontal ligament, and cementum. [128] However, the effect of this multilayer scaffold on periodontal complex regeneration still needs to be verified in vivo. Depending on the specific goals of material fabrication, the advantages of different aspects of amorphous mineral precursors can be grafted into the material individually or in assemblies.…”

Section: Acp Nanoparticlesmentioning

confidence: 99%

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confidence: 99%

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Journey of Mineral Precursors in Bone Mineralization: Evolution and Inspiration for Biomimetic Design

Zhang,

Ma,

Nie

et al. 2023

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Bone mineralization is a ubiquitous process among vertebrates that involves a dynamic physical/chemical interplay between the organic and inorganic components of bone tissues. It is now well documented that carbonated apatite, an inorganic component of bone, is proceeded through transient amorphous mineral precursors that transforms into the crystalline mineral phase. Here, the evolution on mineral precursors from their sources to the terminus in the bone mineralization process is reviewed. How organisms tightly control each step of mineralization to drive the formation, stabilization, and phase transformation of amorphous mineral precursors in the right place, at the right time, and rate are highlighted. The paradigm shifts in biomineralization and biomaterial design strategies are intertwined, which promotes breakthroughs in biomineralization‐inspired material. The design principles and implementation methods of mineral precursor‐based biomaterials in bone graft materials such as implant coatings, bone cements, hydrogels, and nanoparticles are detailed in the present manuscript. The biologically controlled mineralization mechanisms will hold promise for overcoming the barriers to the application of biomineralization‐inspired biomaterials.

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Section: Discussionmentioning

confidence: 99%

Section: Acp Nanoparticlesmentioning

confidence: 99%

Section: Acp Nanoparticlesmentioning

confidence: 99%

mentioning

confidence: 99%

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