Regenerative Medicine Approaches for Treatment of Osteoarthritis

Abstract

Key Points• To be effective, regenerative medicine-based treatment strategies for osteoarthritis (OA) should address multiple aspects of OA -which involves infl ammation, loss of chondrocytes, remodeling of subchondral bone and endochondral ossifi cation.• Biologics involving growth factors to trigger appropriate chondrocyte proliferation, anti-infl ammatory cytokines to combat infl ammation, and the use of cartilage transcription factors are being considered in clinical investigations for the treatment of OA.• Cellular therapy, including autologous chondrocytes, allogeneic cadaveric chondrocytes, mesenchymal stromal cells, and pluripotent stem cellderived chondrocytes, is also being investigated for their ability to directly or indirectly replace the loss of chondrocytes.236