Regenerative injection therapy and repetitive transcranial magnetic stimulation in primary fibromyalgia treatment: A comparative study

El-Ghany, Salwa El-Morsy Abd; Ashkar, Doaa Shawky Al; El-Barbary, Amal Mohamad; Khouly, Radwa Mostafa El; Aboelhawa, Marwa Ahmed; Nada, Doaa Waseem; Darwish, Nivine F; Hussein, Manal Shawky; Rageh, El Sayed M; Abo-Zaid, Mohamed H; Eldesoky, Islam F; Afifi, Samah

doi:10.3233/bmr-181127

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…The treatment in these two RCTs consisted of 10-15 sessions of 10-Hz rTMS that targeted the left DLPFC. In 2019, Abd Elghany et al (62) prospectively recruited 120 patients with FM and compared the effectiveness of 10-Hz rTMS over the left DLPFC with prolotherapy. The results showed that the VAS scores and tenderness points were decreased in patients who received prolotherapy (60 patients) as compared with those in patients who received rTMS (60 patients); however, rTMS had better results on depression.…”

Section: Fibromyalgiamentioning

confidence: 99%

Effect of Repetitive Transcranial Magnetic Stimulation on Pain Management: A Systematic Narrative Review

Yang

Lee

2020

Front. Neurol.

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Recently, clinicians have been using repetitive transcranial magnetic stimulation (rTMS) for treating various pain conditions. This systematic narrative review aimed to examine the use and efficacy of rTMS for controlling various pain conditions. A PubMed search was conducted for articles that were published until June 7, 2019 and used rTMS for pain alleviation. The key search phrase for identifying potentially relevant articles was (repetitive transcranial magnetic stimulation AND pain). The following inclusion criteria were applied for article selection: (1) patients with pain, (2) rTMS was applied for pain management, and (3) follow-up evaluations were performed after rTMS stimulation to assess the reduction in pain. Review articles were excluded. Overall, 1,030 potentially relevant articles were identified. After reading the titles and abstracts and assessing eligibility based on the full-text articles, 106 publications were finally included in our analysis. Overall, our findings suggested that rTMS is beneficial for treating neuropathic pain of various origins, such as central pain, pain from peripheral nerve disorders, fibromyalgia, and migraine. Although data on the use of rTMS for orofacial pain, including trigeminal neuralgia, phantom pain, low back pain, myofascial pain syndrome, pelvic pain, and complex regional pain syndrome, were promising, there was insufficient evidence to determine the efficacy of rTMS for treating these conditions. Therefore, further studies are needed to validate the effects of rTMS on pain relief in these conditions. Overall, this review will help guide clinicians in making informed decisions regarding whether rTMS is an appropriate option for managing various pain conditions.

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Section: Fibromyalgiamentioning

confidence: 99%

Effect of Repetitive Transcranial Magnetic Stimulation on Pain Management: A Systematic Narrative Review

Yang

Lee

2020

Front. Neurol.

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“…One study examined the use of rTMS in patients with fibromyalgia but lacked a sham control group, instead comparing it to prolotherapy [ 76 ]. Although recent meta-analyses have included numerous randomized controlled trials (RCTs), they have not incorporated the high-quality RCT conducted by Argaman in 2021 [ 43 ], which specifically targeted the right M1 brain region for the first time, and as described in the literature, Argaman’s study revealed significant outcomes, showing marked reductions in MPQ-VAS and BPI-severity scores, as well as decreases in FIQ and MPQ-affective scores following 10 Hz rTMS.…”

Section: Non-invasive Repetitive Transcranial Magnetic Stimulation Of...mentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation in Fibromyalgia: Exploring the Necessity of Neuronavigation for Targeting New Brain Regions

Velickovic,

Radunovic

2024

JPM

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Fibromyalgia and osteoarthritis are among the most prevalent rheumatic conditions worldwide. Nonpharmacological interventions have gained scientific endorsements as the preferred initial treatments before resorting to pharmacological modalities. Repetitive transcranial magnetic stimulation (rTMS) is among the most widely researched neuromodulation techniques, though it has not yet been officially recommended for fibromyalgia. This review aims to summarize the current evidence supporting rTMS for treating various fibromyalgia symptoms. Recent findings: High-frequency rTMS directed at the primary motor cortex (M1) has the strongest support in the literature for reducing pain intensity, with new research examining its long-term effectiveness. Nonetheless, some individuals may not respond to M1-targeted rTMS, and symptoms beyond pain can be prominent. Ongoing research aims to improve the efficacy of rTMS by exploring new brain targets, using innovative stimulation parameters, incorporating neuronavigation, and better identifying patients likely to benefit from this treatment. Summary: Noninvasive brain stimulation with rTMS over M1 is a well-tolerated treatment that can improve chronic pain and overall quality of life in fibromyalgia patients. However, the data are highly heterogeneous, with a limited level of evidence, posing a significant challenge to the inclusion of rTMS in official treatment guidelines. Research is ongoing to enhance its effectiveness, with future perspectives exploring its impact by targeting additional areas of the brain such as the medial prefrontal cortex, anterior cingulate cortex, and inferior parietal lobe, as well as selecting the right patients who could benefit from this treatment.

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The effectiveness and safety of electrotherapy in the management of fibromyalgia

Benlidayı

2020

Rheumatol Int

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Regenerative injection therapy and repetitive transcranial magnetic stimulation in primary fibromyalgia treatment: A comparative study

Cited by 5 publications

References 36 publications

Effect of Repetitive Transcranial Magnetic Stimulation on Pain Management: A Systematic Narrative Review

Effect of Repetitive Transcranial Magnetic Stimulation on Pain Management: A Systematic Narrative Review

Repetitive Transcranial Magnetic Stimulation in Fibromyalgia: Exploring the Necessity of Neuronavigation for Targeting New Brain Regions

The effectiveness and safety of electrotherapy in the management of fibromyalgia

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