Regenerative Engineering: A Review of Recent Advances and Future Directions

Esdaille, Caldon Jayson; Washington, Kenyatta S.; Laurencin, Cato T.

doi:10.2217/rme-2021-0016

Cited by 19 publications

(4 citation statements)

References 89 publications

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“…Skin substitutes aid wound healing, while engineered organs strive to overcome the organ shortage crisis. Tissue engineering has emerged as a transformative solution for cartilage repair, aiming to overcome the challenges posed by the limited self-renewal capacity of articular cartilage [67].…”

Section: Tissue Engineeringmentioning

confidence: 99%

Cartilage: Structure, Function, and the Pathogenesis of Osteoarthritis

ur Rehman,

Iqbal,

Umair Shahid

et al. 2024

Advancements in Synovial Joint Science - Structure, Function, and Beyond

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This chapter provides an in-depth exploration of cartilage, a pivotal component crucial for joint health, particularly within the context of osteoarthritis (OA). It delves deeply into the intricate structure and dynamic functions of articular cartilage, elucidating its essential roles in load-bearing, shock absorption, and maintaining joint stability. Emphasizing the delicate balance of cellular components, such as chondrocytes, and extracellular matrix constituents like proteoglycans and collagens, which collectively ensure the mechanical and biological integrity of cartilage, the discussion places significant attention on factors influencing cartilage homeostasis and contributing to its eventual degradation, analyzing age-related changes, mechanical stress, and genetic predispositions, alongside the impact of inflammatory processes and cytokine imbalances. By highlighting the multifaceted interplay among these factors, a clear narrative emerges, elucidating the initiation of OA. Furthermore, the chapter investigates into the cascade of events that define OA pathogenesis, dissecting the underlying mechanisms responsible for cartilage damage and matrix degradation, tracing their combined contribution toward the development of OA. In its focus on OA’s etiology, the chapter underscores importance of comprehending cartilage alterations as a critical starting point for designing therapeutic interventions aimed at effectively managing OA.

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Section: Tissue Engineeringmentioning

confidence: 99%

Cartilage: Structure, Function, and the Pathogenesis of Osteoarthritis

ur Rehman,

Iqbal,

Umair Shahid

et al. 2024

Advancements in Synovial Joint Science - Structure, Function, and Beyond

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“…Although they are both based on the idea that new tissues can be generated from living cells seeded on a scaffold [ 57 ], TE is an ex vivo procedure in which cells are seeded into a scaffold, giving them physical, chemical and mechanical stimuli in order to generate a fully tissue that can be later implanted in the affected tissue, while RM is an in vivo procedure, in which a biomaterial scaffold with or without seeded cells is directly implanted into the body to facilitate regeneration of the defected area [ 58 ]. Nowadays, the two disciplines are known together as TERM [ 58 ] and create a multidisciplinary field of research [ 59 ], from life sciences to biology and engineering [ 60 ]. They are based on three key factors: scaffolds, cells and regulatory signals [ 61 ].…”

Section: The Innovation Of Tissue Engineering and Regenerative Medici...mentioning

confidence: 99%

Recent Advances in Functionalized Electrospun Membranes for Periodontal Regeneration

Epicoco,

Pellegrino,

Madaghiele

et al. 2023

Pharmaceutics

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Periodontitis is a global, multifaceted, chronic inflammatory disease caused by bacterial microorganisms and an exaggerated host immune response that not only leads to the destruction of the periodontal apparatus but may also aggravate or promote the development of other systemic diseases. The periodontium is composed of four different tissues (alveolar bone, cementum, gingiva, and periodontal ligament) and various non-surgical and surgical therapies have been used to restore its normal function. However, due to the etiology of the disease and the heterogeneous nature of the periodontium components, complete regeneration is still a challenge. In this context, guided tissue/bone regeneration strategies in the field of tissue engineering and regenerative medicine have gained more and more interest, having as a goal the complete restoration of the periodontium and its functions. In particular, the use of electrospun nanofibrous scaffolds has emerged as an effective strategy to achieve this goal due to their ability to mimic the extracellular matrix and simultaneously exert antimicrobial, anti-inflammatory and regenerative activities. This review provides an overview of periodontal regeneration using electrospun membranes, highlighting the use of these nanofibrous scaffolds as delivery systems for bioactive molecules and drugs and their functionalization to promote periodontal regeneration.

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“…Due to increasing aging population, the quality of our lives seems to rely on our capacity to regenerate impaired or ill tissues that lack the inherent ability to self-repair or renew into fully functional organs. As a result, the field of tissue engineering has provided possible solutions for this purpose [1,2]. Most of the body tissues are supplied with complex network of blood vessels, and their effective operation hinges on the circulation and diffusion of nutrients and oxygen, as well as the waste removal through nearby blood vessels.…”

Section: Introductionmentioning

confidence: 99%

Vascularized Liver Tissue Embedded Bioprinting Utilizing GelMA/Nanoclay-based Composite hydrogels

Rezaei,

Dixit,

Kumar

et al. 2023

Preprint

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As the aging population grows, the need to regenerate non-self-repairing tissues becomes increasingly crucial for enhancing our quality of life. Tissue engineering offers a promising solution, particularly in recreating the intricate networks of blood vessels crucial for tissue vitality. These tissues rely on effective nutrient and oxygen circulation, with an optimal oxygen diffusion range of 100–200 µm. Yet, crafting vascularized in vitro tissues remains a significant challenge. This study addresses the challenge by using GelMA-based hydrogels as a photocrosslinkable support bath, a biocompatible and versatile choice for biological applications. To enhance the rheological properties for in vitro tissue engineering, Laponite (LPN) is introduced as a rheology modifier. The study optimizes the GelMA-LPN nanocomposite hydrogel composition, ensuring the desired physical, mechanical, and rheological properties, including recovery. The research also explores the biological implications, encapsulating liver cells within the nanocomposite hydrogel, and studying their behavior under perfusion conditions. This research presents a promising avenue for creating vascularized in vitro tissues, potentially advancing tissue engineering and regenerative medicine.

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Regenerative Engineering: A Review of Recent Advances and Future Directions

Cited by 19 publications

References 89 publications

Cartilage: Structure, Function, and the Pathogenesis of Osteoarthritis

Cartilage: Structure, Function, and the Pathogenesis of Osteoarthritis

Recent Advances in Functionalized Electrospun Membranes for Periodontal Regeneration

Vascularized Liver Tissue Embedded Bioprinting Utilizing GelMA/Nanoclay-based Composite hydrogels

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