Regenerative Endodontics Versus Apexification in Immature Permanent Teeth with Apical Periodontitis: A Prospective Randomized Controlled Study

Lin, Jiacheng; Zeng, Qian; Wei, Xi; Zhao, Wei; Cui, Min; Gu, Jing; Lu, Jiarui; Yang, Maobin; Ling, Junqi

doi:10.1016/j.joen.2017.06.023

Cited by 166 publications

(257 citation statements)

References 26 publications

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“…() and Lin et al . (), both without minocycline, revealed more than a half and 44% of the treated teeth were discoloured, respectively. The review conducted by Torabinejad et al .…”

Section: Clinical Implications Of the Use Of Antibiotics In Repsmentioning

confidence: 95%

“…A prospective randomized controlled study (Lin et al . ) compared the outcome of regenerative endodontics and apexification in immature permanent teeth with apical periodontitis. The study included 69 regenerative endodontic treatments (RET) carried out using triple antibiotic paste‐containing ciprofloxacin, metronidazole and clindamycin.…”

Section: Clinical and Experimental Studies On Efficacy Of Antibioticsmentioning

confidence: 99%

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Effectiveness and clinical implications of the use of topical antibiotics in regenerative endodontic procedures: a review

et al. 2018

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Regenerative endodontic procedures (REPs) are biologically based procedures planned to replace damaged tissues, including dentinee and root structures, as well as cells of the pulp-dentine complex. Effective sterilization of the root canal is essential in REPs, and antibiotics have been widely used to disinfect root canals. The aim of this paper was to review the scientific literature on (i) Effectiveness of antibiotics used in REPs against bacteria implicated in endodontic disease; (ii) Scientific evidence supporting the use of topical antibiotics in REPs; (iii) Clinical implications of the use of antibiotics in REPs and the possible side effects; (iv) Effect of antibiotics on dental pulp stem cells; and (v) Ongoing research on the use of antibiotics in REPs. Antibiotics used in REPs are effective against bacteria implicated in endodontic infections. Triple antibiotic pastes with minocycline attain complete disinfection of immature teeth with necrotic pulps, without affecting SCAP. Experimental studies carried out in dogs support the use of antibiotics in REPs. Clinical studies report high success rates of RET using antibiotics as intracanal dressings. However, tooth discolouration is an important side effect of the use of TAP. An antibiotic paste containing only metronidazole and ciprofloxacin could be a good alternative to the use of TAP. The use of antibiotic-containing scaffolds or clindamycin-modified triple antibiotic (metronidazole, ciprofloxacin and clindamycin) polymer could be a biologically safe antimicrobial drug delivery system in REPs.

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“…() and Lin et al . (), both without minocycline, revealed more than a half and 44% of the treated teeth were discoloured, respectively. The review conducted by Torabinejad et al .…”

Section: Clinical Implications Of the Use Of Antibiotics In Repsmentioning

confidence: 95%

Section: Clinical and Experimental Studies On Efficacy Of Antibioticsmentioning

confidence: 99%

Effectiveness and clinical implications of the use of topical antibiotics in regenerative endodontic procedures: a review

et al. 2018

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“…, Lin et al . ). Consequently, the disinfection protocol in RET is not the only determined factor related to root maturation.…”

Section: Triple Antibiotic Pastementioning

confidence: 97%

Regenerative endodontics: a comprehensive review

et al. 2018

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The European Society of Endodontology and the American Association for Endodontists have released position statements and clinical considerations for regenerative endodontics. There is increasing literature on this field since the initial reports of Iwaya et al. (Dental Traumatology, 17, 2001, 185) and Banchs & Trope (Journal of Endodontics, 30, 2004, 196). Endogenous stem cells from an induced periapical bleeding and scaffolds using blood clot, platelet rich plasma or platelet-rich fibrin have been utilized in regenerative endodontics. This approach has been described as a 'paradigm shift' and considered the first treatment option for immature teeth with pulp necrosis. There are three treatment outcomes of regenerative endodontics; (i) resolution of clinical signs and symptoms; (ii) further root maturation; and (iii) return of neurogenesis. It is known that results are variable for these objectives, and true regeneration of the pulp/dentine complex is not achieved. Repair derived primarily from the periodontal and osseous tissues has been shown histologically. It is hoped that with the concept of tissue engineering, namely stem cells, scaffolds and signalling molecules, that true pulp regeneration is an achievable goal. This review discusses current knowledge as well as future directions for regenerative endodontics. Patient-centred outcomes such as tooth discolouration and possibly more appointments with the potential for adverse effects needs to be discussed with patients and parents. Based on the classification of Cvek (Endodontics and Dental Traumatology, 8, 1992, 45), it is proposed that regenerative endodontics should be considered for teeth with incomplete root formation although teeth with near or complete root formation may be more suited for conventional endodontic therapy or MTA barrier techniques. However, much is still not known about clinical and biological aspects of regenerative endodontics.

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“…79 However, the success of this procedure at the histologic level was significantly improved if bacteria were eliminated compared with cases with persistent bacteria in vivo. 81 81 …”

Section: Prevotella Intermedia 26mentioning

confidence: 99%

Microbiological aspects of traumatic injuries

Fouad

2019

Dental Traumatology

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After traumatic injuries to teeth, microorganisms may invade the compromised pulp tissue and initiate pulp infection and periapical inflammation. In addition to bone resorption that typically accompanies pulp necrosis, root resorption frequently occurs.Root resorption has several variants that may occur shortly after the trauma or at a later stage. The pathological changes seen after traumatic injuries to teeth are invariably linked to the presence of microbial irritants. The presence of bacterial biofilms in the dental pulp space can be treated with regenerative or therapeutic endodontic procedures. However, necrosis of periodontal ligament is usually terminal for the tooth involved. In this review, the sources of bacteria after traumatic injuries are discussed. The types and role of microorganisms involved in the pathogenesis of endodontic pathosis after traumatic injuries are presented, and contemporary approaches for the management of these conditions are reviewed. Contemporary antimicrobial strategies are discussed. The rationale for the use of systemic and topical antimicrobials is presented. Finally, novel approaches to the use of antimicrobial therapies, particularly in regenerative procedures, are reviewed.

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Regenerative Endodontics Versus Apexification in Immature Permanent Teeth with Apical Periodontitis: A Prospective Randomized Controlled Study

Cited by 166 publications

References 26 publications

Effectiveness and clinical implications of the use of topical antibiotics in regenerative endodontic procedures: a review

Effectiveness and clinical implications of the use of topical antibiotics in regenerative endodontic procedures: a review

Regenerative endodontics: a comprehensive review

Microbiological aspects of traumatic injuries

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