Regenerative Endodontic Procedures: A Perspective from Stem Cell Niche Biology

Marí‐Beffa, Manuel; Segura-Egea, Juan José; Díaz‐Cuenca, Aránzazu

doi:10.1016/j.joen.2016.09.011

Cited by 27 publications

(27 citation statements)

References 170 publications

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“…In this respect, functional aspects of BECs, as the optimal hydration process and kinetics, biomechanical performance, and the role played by the radiopacifying agents are being studied. Recently, research on BECs has focused on their applications as active therapeutic agents to stimulate tissue regeneration …”

Section: Introductionmentioning

confidence: 99%

Higher hydration performance and bioactive response of the new endodontic bioactive cement MTA HP repair compared with ProRoot MTA white and NeoMTA plus

2019

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The aim of this study was to characterize the hydration performance and the bioactive response of the new bioactive endodontic cement MTA HP repair (HP), comparing its physicochemical parameters with those of ProRoot MTA White (Pro) and NeoMTA Plus (Neo). Un-hydrated precursor materials were characterized by X-ray fluorescence, laser diffraction, N 2 physisorption and field emission gun scanning electron microscopy (FEG-SEM). Setting time was assessed according to ASTM specification C 266. Hydrated materials were analyzed by X-ray diffraction, Fourier transform infrared spectroscopy (FT-IR) and (FEG-SEM). Bioactivity evaluation in vitro was carried out, by soaking processed cement disk in simulated body fluid (SBF) during 168 h. The cements surface was studied by FT-IR, FEG-SEM, and energy dispersive X-ray. Release to the SBF media of ionic degradation products was monitored using inductively coupled plasma atomic emission spectroscopy. HP showed shorter initial setting time compared to Pro and Neo and produce a quick and effective bioactive response in vitro in terms of phosphate phase surface coating formation. This higher bioactive response for HP is correlated with increasing calcium aluminate content, increasing surface area of un-hydrated powder precursor and the increasing release capacity of Si ionic products of the final hydrated product. The higher bioactive response of MTA HP repair highlights this material, as very interesting to further investigate its performance to improve the outcome of vital pulp therapy procedures.

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Section: Introductionmentioning

confidence: 99%

Higher hydration performance and bioactive response of the new endodontic bioactive cement MTA HP repair compared with ProRoot MTA white and NeoMTA plus

2019

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“…Recently, a synthetic polymer polycaprolactone was successful in growing increasing numbers of stem cells from apical papilla stem cells with apparent identification of NOTCH signaling expression. [23][24][25][26] Although the number of scaffolds has increase questions remain that must be addressed.…”

Section: Scaffoldsmentioning

confidence: 99%

“…The peptide system is referred to as a tunable matrix with several features that possibly allow scaffolds to be designed, as different requirements are needed to regenerate a tissue. [10,[25][26][27][28] …”

Section: Scaffoldsmentioning

confidence: 99%

“…The signaling proteins functioning in these processes have been studied but more research is needed to determine the mechanisms that allow stem cells from a particular niche to increase in number and migrate to the area of injury. [26,27] Questions arise as to the environment of the niche surrounding the stem cells. Does that environment maintain stem cell lineage specificity?…”

Section: Vascularizationmentioning

confidence: 99%

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Future prospects in endodontic regeneration - A review article

Mookhtiar¹,

Hegde²,

Shanmugsundaram³

2018

IDJAR

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“…Differentiated dentinoblasts, also called secondary odontoblasts, produce new dentine in response to dental cell injury. This regenerative process is called reparative tertiary dentinogenesis 11 . This process of dentinogenesis was suggested to be used in the recruitment of endogenous DSCs.…”

Section: Introductionmentioning

confidence: 99%

Dental stem cells in tooth repair: A systematic review

2019

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Background: Dental stem cells (DSCs) are self-renewable teeth cells, which help maintain or develop oral tissues. These cells can differentiate into odontoblasts, adipocytes, cementoblast-like cells, osteoblasts, or chondroblasts and form dentin/pulp. This systematic review aimed to summarize the current evidence regarding the role of these cells in dental pulp regeneration. Methods: We searched the following databases: PubMed, Cochrane Library, MEDLINE, SCOPUS, ScienceDirect, and Web of Science using relevant keywords. Case reports and non-English studies were excluded. We included all studies using dental stem cells in tooth repair whether in vivo or in vitro studies. Results: Dental pulp stem cell (DPSCs) is the most common type of cell. Most stem cells are incorporated and implanted into the root canals in different scaffold forms. Some experiments combine growth factors such as TDM, BMP, and G-CSF with stem cells to improve the results. The transplant of DPSCs and stem cells from apical papilla (SCAPs) was found to be associated with pulp-like recovery, efficient revascularization, enhanced chondrogenesis, and direct vascular supply of regenerated tissue. Conclusion: The current evidence suggests that DPSCs, stem cells from human exfoliated deciduous teeth, and SCAPs are capable of providing sufficient pulp regeneration and vascularization. For the development of the dental repair field, it is important to screen for more effective stem cells, dentine releasing therapies, good biomimicry scaffolds, and good histological markers.

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Regenerative Endodontic Procedures: A Perspective from Stem Cell Niche Biology

Cited by 27 publications

References 170 publications

Higher hydration performance and bioactive response of the new endodontic bioactive cement MTA HP repair compared with ProRoot MTA white and NeoMTA plus

Higher hydration performance and bioactive response of the new endodontic bioactive cement MTA HP repair compared with ProRoot MTA white and NeoMTA plus

Future prospects in endodontic regeneration - A review article

Dental stem cells in tooth repair: A systematic review

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