Regenerative Endodontic Procedure of Immature Permanent Teeth with Leukocyte and Platelet-rich Fibrin: A Multicenter Controlled Clinical Trial

Evaluation of the Effectiveness of Laser-Assisted Bleaching of the Teeth Discolored due to Regenerative Endodontic Treatment

“…Considering the discoloration potential of blood per se and the role of it in intensifying the discoloration caused by HCSCs [5], alternative sca olds may be preferred in RETs, provided that they meet the criteria of an ideal sca old. Sca olds such as platelet-rich brin (PRF) and platelet-rich plasma (PRP) have been associated with favorable and successful results in previous studies [38][39][40][41][42][43]. Although PRF has been addressed as an ideal purely autologous sca old for regeneration [44,45], there is not enough evidence available to substitute blood clot with another sca old.…”

Biomaterial scaffolds for clinical procedures in endodontic regeneration

“…In recent years, L-PRF has been used as a biomaterial scaffold in REPs in an immature permanent tooth in association with apical surgery [ 106 ] or in autologous DPSCs therapy for a mature permanent tooth with symptomatic irreversible pulpitis [ 113 ]. A multicenter controlled clinical trial was recently reported to evaluate the effect of L-PRF on REPs of immature permanent teeth [ 114 ]. Twenty-nine patients between 6 and 25 years with an inflamed or necrotic immature permanent tooth were included and divided into the test group (REPs with L-PRF) and control group (REPs without L-PRF).…”

“…Collagen possesses complex supramolecular structure, which provides a highly organized structural and biological framework [ 122 ]. Collagen has the potential to be used as a biomaterial in tissue engineering because of its biocompatible and biodegradable properties [ 113 , 114 ]. To date, different collagen-based scaffolds have been used for dental pulp regeneration, including pure collagen scaffolds (i.e., collagen sponge, pellet and membrane), collagen-based scaffolds combined with other natural or synthetic material, as well as composite scaffolds comprising collagen, growth factors or stem cells [ [115] , [116] , [117] , [118] , [119] , [120] , [121] , [122] , [123] , [124] , [125] , [126] , [127] , [128] ].…”

Clinical Outcome and Comparison of Regenerative and Apexification Intervention in Young Immature Necrotic Teeth—A Systematic Review and Meta-Analysis

“…Thirty-two articles were included in this study (Table 3). Eighteen articles [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] evaluated the clinical outcome of regenerative endodontic procedures (REP) and five articles [34][35][36][37][38] on the apexification procedure. Only nine articles [39][40][41][42][43][44][45][46][47] evaluated and compared the clinical outcome between regeneration and apexification procedure.…”

“…In total, of the 18 articles [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] evaluating regeneration outcomes, 14 articles [16][17][18][19][20][21][22][23][24][25][26][27][28]33] were randomized clinical trials, and 4 articles [29][30][31][32] were non-randomized clinical articles. In randomized clinical trials, a total of 393 participants and 412 teeth were included.…”