2017
DOI: 10.1093/asj/sjx015
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Regenerative Cells for the Management of Osteoarthritis and Joint Disorders: A Concise Literature Review

Abstract: As the global population ages, the prevalence of osteoarthritis (OA) and joint disorders represent a major cause of disability and a significant public health burden. As current approaches for the management of OA focus on slowing the progression of disease, without repairing the underlying damage, novel treatments are necessary to improve outcomes. Over the past decade, autologous cell-based therapies using regenerative cells from fat or bone marrow have become a major focus of research into new approaches fo… Show more

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Cited by 10 publications
(10 citation statements)
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“…OA features chronic degradation of joint cartilage, subchondral bone sclerosis, and degradation of the articular fringe [6]. OA is prevalent on the articular surfaces of the hands, elbows, hips, and knees [27].…”
Section: Discussionmentioning
confidence: 99%
“…OA features chronic degradation of joint cartilage, subchondral bone sclerosis, and degradation of the articular fringe [6]. OA is prevalent on the articular surfaces of the hands, elbows, hips, and knees [27].…”
Section: Discussionmentioning
confidence: 99%
“…[7][8][9] Orthobiologic products (such as mesenchymal stem cells, bone marrow aspirate concentrate, and platelets rich products) are showing promise as safe and effective treatments for musculoskeletal diseases including osteoarthritis in people and animals. [10][11][12][13][14][15][16][17][18] Platelets possess anabolic and anti-inflammatory properties attributed to the delivery of various growth factors and cell signaling molecules that can modulate inflammation and promote tissue healing. 19,20 Because various methods exist to create different platelet-derived orthobiologics, we define platelet-rich plasma (PRP) as any product in which the concentration of platelets is increased relative to whole blood and partially or fully isolated from leukocytes and red cells within a plasma medium.…”
Section: Introductionmentioning
confidence: 99%
“…Joint cartilage, ligaments, subchondral bone, capsule and adjacent muscles are vulnerable to OA [21,22]. OA has the characteristics of chronic joint cartilage degradation and articular fringe as well as subchondral bone sclerosis of the hands, elbows, knees and hips [23,24]. The proliferation and apoptosis of normal articular chondrocytes are in a certain state of equilibrium that ensures the number of articular chondrocytes.…”
Section: Discussionmentioning
confidence: 99%