Regeneration potential of bone marrow derived mesenchymal stem cells and platelet rich plasma (PRP) on irradiation-induced damage of submandibular salivary gland in albino rats

Nh, Mohamed; Shawkat, S; Moussa, MS; Ahmed, NEB

doi:10.1016/j.tice.2022.101780

Cited by 4 publications

(2 citation statements)

References 64 publications

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“…PRP is the most widely studied platelet concentrate in regenerative medicine with many investigations demonstrating its benefit in cardiac surgery [ 35 ], osteoarthritis [ 36 ], osteoporosis [ 37 ], dermal rejuvenation [ 34 ], and dentistry [ 38 , 39 ]. It possesses antimicrobial [ 40 ], anti-inflammatory [ 41 ], and regenerative properties [ 42 ]. A second generation platelet concentrate was later termed platelet-rich fibrin (PRF) which was developed with the aim of removing the anticoagulant to favor better healing (Since clotting is one of the first steps to healing) [ 28 , 43 , 44 ].…”

Section: Pdbs Used In Clinical Therapiesmentioning

confidence: 99%

The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence

Amiri,

Farshidfar,

Miron

et al. 2023

International Journal of Biomaterials

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Osteoporosis is a chronic multifactorial condition that affects the skeletal system, leading to the deterioration of bone microstructure and an increased risk of bone fracture. Platelet-derived biomaterials (PDBs), so-called platelet concentrates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), have shown potential for improving bone healing by addressing microstructural impairment. While the administration of platelet concentrates has yielded positive results in bone regeneration, the optimal method for its administration in the clinical setting is still debatable. This comprehensive review aims to explore the systemic and local use of PRP/PRF for treating various bone defects and acute fractures in patients with osteoporosis. Furthermore, combining PRP/PRF with stem cells or osteoinductive and osteoconductive biomaterials has shown promise in restoring bone microstructural properties, treating bony defects, and improving implant osseointegration in osteoporotic animal models. Here, reviewing the results of in vitro and in vivo studies, this comprehensive evaluation provides a detailed mechanism for how platelet concentrates may support the healing process of osteoporotic bone fractures.

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Section: Pdbs Used In Clinical Therapiesmentioning

confidence: 99%

The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence

Amiri,

Farshidfar,

Miron

et al. 2023

International Journal of Biomaterials

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show abstract

“…However, in some cases, due to factors such as the location or severity of the tumor (Robar et al 2007), SGs are still being injured. Recently, a cell-free biological therapy using an extract of bone marrow cells (BMCs) was proposed because it would be theoretically less thromboembolic and immunogenic than other experimental approaches, such as gene or stem cell–based therapy (Ferreira et al 2018; Mohamed et al 2022), being currently evaluated for restoring saliva secretion (Angeli et al 2012). This cell-free extract consisted of soluble contents lysed from whole cells.…”

Section: Introductionmentioning

confidence: 99%

Human Bone Marrow Cell Extracts Mitigate Radiation Injury to Salivary Gland

Liu

Seuntjens

et al. 2022

J Dent Res

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Mitigation of irradiation injury to salivary glands was previously reported using a cell-free extract from mouse bone marrow. However, to bring this potential therapy a step closer to clinical application, a human bone marrow cell extract (BMCE) needs to be tested. Here, we report that irradiation-induced injury of salivary glands in immunocompetent mice treated with human BMCE secreted 50% more saliva than saline-injected mice, and BMCE did not cause additional acute inflammatory reaction. In addition, to identify the cell fraction in BMCE with the most therapeutic activity, we sorted human bone marrow into 3 cell fractions (mononuclear, granulocyte, and red blood cells) and tested their respective cell extracts. We identified that the mononuclear cell extract (MCE) provided the best therapeutic efficacy. It increased salivary flow 50% to 73% for 16 wk, preserved salivary parenchymal and stromal cells, and doubled cell proliferation rates while producing less inflammatory response. In contrast, the cell extract of granulocytes was of shorter efficacy and induced an acute inflammatory response, while that from red blood cells was not therapeutically effective for salivary function. Several proangiogenic (MMP-8, MMP-9, VEGF, uPA) and antiangiogenic factors (TSP-1, PF4, TIMP-1, PAI-1) were identified in MCE. Added advantages of BMCE and MCE for potential clinical use were that cell extracts from both male and female donors were comparably bioactive and that cell extracts could be stored and transported much more conveniently than cells. These findings suggest human BMCE, specifically the MCE fraction, is a promising therapy against irradiation-induced salivary hypofunction.

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Drug Therapeutics Delivery to the Salivary Glands: Intraglandular and Intraductal Injections

Almansoori

Hariharan

Cao

et al. 2023

Cell Biology and Translational Medicine, Volume 20

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Regeneration potential of bone marrow derived mesenchymal stem cells and platelet rich plasma (PRP) on irradiation-induced damage of submandibular salivary gland in albino rats

Cited by 4 publications

References 64 publications

The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence

The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence

Human Bone Marrow Cell Extracts Mitigate Radiation Injury to Salivary Gland

Drug Therapeutics Delivery to the Salivary Glands: Intraglandular and Intraductal Injections

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